DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HEY1 and dpn

DIOPT Version :9

Sequence 1:	NP_001035798.1	Gene:	HEY1 / 23462	HGNCID:	4880	Length:	308	Species:	Homo sapiens
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	91/316 - (28%)
Similarity:	137/316 - (43%)	Gaps:	51/316 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    10 SSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRR 74
            :||.:.| ......:|...||.:|      :|...|:...||..:.|:|||||.|||:.|:||:.
  Fly     8 NSDDDFD-CSNGYSDSYGSNGRMS------NPNGLSKAELRKTNKPIMEKRRRARINHCLNELKS 65

Human    75 LVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVA 139
            |:..|.:|.....  .|||||:||:|||.||:.:..........:....:.....||.||..||.
  Fly    66 LILEAMKKDPARH--TKLEKADILEMTVKHLQSVQRQQLNMAIQSDPSVVQKFKTGFVECAEEVN 128

Human   140 RYLSIIEGLDASDPLRVRLVSHLNNYASQREA-------ASGAHAGLGHIPWGTVFGHHPHIAHP 197
            ||:|.::|:|..  :|.||.:|||..|:..|.       ::|...||  .| .|.....|....|
  Fly   129 RYVSQMDGIDTG--VRQRLSAHLNQCANSLEQIGSMSNFSNGYRGGL--FP-ATAVTAAPTPLFP 188

Human   198 LLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAP---------PSGSLGPVLPVVTSASK 253
             .|||:.:.|:.|.:|                |||::..         |||....::|...||:.
  Fly   189 -SLPQDLNNNSRTESS----------------APAIQMGGLQLIPSRLPSGEFALIMPNTGSAAP 236

Human   254 LSPPLL--SSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGA 307
            ...|..  .|.|.::|...|.....:.:|..|:..  ||:..:....:|..|.:.|
  Fly   237 PPGPFAWPGSAAGVAAGTASAALASIANPTHLNDY--TQSFRMSAFSKPVNTSVPA 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEY1	NP_001035798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		10/41 (24%)
		bHLH_SF	41..126	CDD:381792	31/84 (37%)
		ORANGE	124..170	CDD:128787	18/45 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..238		9/46 (20%)
		YRPW motif	298..301		0/2 (0%)
dpn	NP_476923.1	HLH	39..101	CDD:238036	29/63 (46%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	18/45 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810