DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA5 and CG31213

DIOPT Version :10

Sequence 1:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens
Sequence 2:NP_732473.2 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster


Alignment Length:1842 Identity:420/1842 - (22%)
Similarity:792/1842 - (42%) Gaps:347/1842 - (18%)


- Green bases have known domain annotations that are detailed below.


Human     6 REVGVWRQTRTLLLKNYLIKCRTKKSSVQEI----LFPLFFLFWLILISMMHPNKKYEEVPNIEL 66
            |.:...::.|.||.|:..::.......|..|    |.|:||.....:...:.|       |:||:
  Fly     3 RNLTYCQKYRLLLWKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFP-------PDIEM 60

Human    67 --NPMDKFTLSNLI--LGYTPVTNITSSIMQKVSTDHLPDVIITEEY-TNEKEMLTSSLSKPSNF 126
              :|..|...::|.  |.:||...|...::.:::  ::.:....|.: ||.:..|...:::  |.
  Fly    61 EKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLA--NISEFKSVEVFDTNSELYLQLMINR--NA 121

Human   127 VGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAIIQLKTNV 191
            :|:.| .|..|:::..|:::.: :|:|.    .|...:..:|:.|||.:||..|....|..|...
  Fly   122 IGIAF-PSEWYDIKSCPEVLNL-TIFMP----LSIKRKDFKYFESGFLLLQERISKIFIFFKNAG 180

Human   192 SLWKELESTKAVIMGETAVVEIDTFP-------------RGVILIYLVIAFSPFGYFLAIHIVAE 243
            :             |:...|.::.||             :.:..:.|:..|.|. ..:|.::|||
  Fly   181 N-------------GKIPRVLMNHFPYPSYVPNHYAESAKAMTYMTLISFFLPC-ITIAKYVVAE 231

Human   244 KEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGL 308
            ||:..|..|..||..::..||:|......|:.|..|:|..|.:..|::..||.:.:..:|.:|..
  Fly   232 KERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIH 296

Human   309 SSVFFALMLTPLFKKSKH---VGIVEFFVT-VAFGFIGLMIILIESFPKSLVWLFSPFCHCTFVI 369
            |.|.||..::..|.:|..   ..|:.:|.| :.|..:|.....:.:...:.:.|.|..   .:::
  Fly   297 SLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLIVGAENSSVAAQTAASIGLNSAL---FYIL 358

Human   370 GIAQVMHLEDFNEGA---SFSNLTAGPYPLIITIIMLTLNSIFYV--LLAVYLDQVIPGEFGLRR 429
            ....||.::  :.||   :..|..:..|.|.|...||.:.||.::  |:.:|::.|..|||.:.:
  Fly   359 DSVAVMEMQ--SVGAQWYTIDNTASSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQ 421

Human   430 SSLYFLKPSYWSKSKRNYEELSEG--------NVNGNISFS---------------EIIEPVS-S 470
            ...|..:..||...:.......:|        |..||:..:               |..:.|: |
  Fly   422 PWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNIS 486

Human   471 EFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535
            :.:|   |.:..:.||:..:  ||  :::|.|::||.:||||:||.|:||:|::.:|||:..|:.
  Fly   487 KKIG---IEVRSLSKTFGFR--NV--VKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTT 544

Human   536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
            |...|.|:.:  :.|...|:..:|||||..:.|..::..:::...:.:||......:.|....:.
  Fly   545 GTVLINGYDI--VTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYIS 607

Human   601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
            .|.:...:...|.:||.|.:|:|||..|:....|::|.|||::|:||..||.:...|:..|..|.
  Fly   608 KLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRT 672

Human   666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATESLSSLVKQH 730
            .:.:|..::|.:|||||.|:::.|.:.|.|:..:||......|.||..:......::|:.||:.:
  Fly   673 ILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLY 737

Human   731 IPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSH-SNLGVISYGVSMTTLEDVFLKLEV---- 790
            :...|....:...:.|.||...:|:|...|..|:.: .:|.|:|:|||.:||:.::|.|:.    
  Fly   738 MTTTTSPVFHGVDVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGS 802

Human   791 --------EAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLL-----------ILSETKAALVST 836
                    ....|:.::.|.|.:.:      ::.|....||:           .:..||.. ::.
  Fly   803 SRLRGGADPGVNDKVEFGVQTDKAI------RTKDRANNSLVRYQHQVDPPNETILNTKTP-INP 860

Human   837 MSLW----KQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLV-----------HHSF 886
            :.:|    :::...:|::....:|:::.:....|:.:||.. :.:|.:::           |.:.
  Fly   861 IEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILI-IPLFYYIIVLGTAASEKCAHRTD 924

Human   887 KNAVVPIKL----VPDLYFLKPGDKP-HKYKTSLLLQ--------NSADSDISDLI--------- 929
            |..|:|:.|    ..|:..|...||. :|.:....:|        .|.||..|.|:         
  Fly   925 KQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPIIRRD 989

Human   930 --------SFFTSQNIMVTMINDSDYVSVAPHSAALNVMHSE------KDYVFAAVFNSTMVYSL 980
                    :.|.:.:.:....|...:...||  .|||::::.      :|..|:.:.|...::..
  Fly   990 IKRKYVCGASFNNASTITAWFNSDAFEHSAP--IALNLVYNALGKAVFEDQDFSILVNRGDLHDF 1052

Human   981 PILVNIISNYYLYHLNVTETIQIWSTPFFQEITDIVFK--------------------------- 1018
            ..|.|..|....|..........:|....||. |:|.|                           
  Fly  1053 IWLNNASSMRRRYKRQNDPDYTDYSDYEIQEY-DVVVKPNSSSTSGQHNKSNPGDDNIITVQMSI 1116

Human  1019 IE----LYFQAA----LLG--IIVTAMPPYFAM-----------ENAENHKIKAYTQLKLSGLLP 1062
            ||    ||.:..    |.|  ||:||   |.|:           |..|:.|:    |.::.|:..
  Fly  1117 IEAASTLYNEKGKRKQLFGTLIIITA---YIALCLSIFSIFVTKERVEHFKM----QQEIYGVTL 1174

Human  1063 SAYWIGQAVVDIPLFFIILILMLGSL--LAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASF 1125
            ..:|....|.|    |:|..:.:|:|  ..:|:.:::..|    |:..|||:  :.:.|.|:.|.
  Fly  1175 FYFWSTHFVGD----FLIYAIYMGALTIAIYHFTIWYQVV----VMLLLIGF--ACLPFVYLCSL 1229

Human  1126 TFKKILNTKEFWSFIYSVAALACIAITEIT----FFMGYTIATILHYAFCIIIPIYPL-LGCLIS 1185
            .|.           :.::|.....||..:|    |...|.:..|....|..:..|.|: :|....
  Fly  1230 LFS-----------LPNIAFAGIFAILVMTGGMLFSFMYMLTLITDVNFTTVFAILPMYVGTFGL 1283

Human  1186 FIKISWKNVRKNVDTYNPWDRLS------------------VAVISPYLQCVLWIFLLQY----Y 1228
            |..::|:.. .|.:...|.:.|.                  :.|....:.|::|...|.:    |
  Fly  1284 FKCLAWREY-CNREVLPPIEELDCKFGNCNVFCACKPERTWMEVWLLMVHCLVWFIFLWFSNFGY 1347

Human  1229 EKKYGGRSIRKDPFFRN----LSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPS 1289
            |..|..:....:..:.|    :....:.|::...|..|.||.                      .
  Fly  1348 EIGYRFKPKLSNRIWHNNEKHIRVLDEERRVGLIPKYEHEDY----------------------P 1390

Human  1290 IMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS 1354
            |:|..:.|.|...|:          |.:.:||.::.|:..||||..||||::|..::.|:...:.
  Fly  1391 IIVDQVTKNYCRAKN----------AVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSH 1445

Human  1355 GQVFLGDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHA 1419
            |.:::..:|.....:...:: :|:|||.:......|.::...|:..:.|:....:|.|..::...
  Fly  1446 GNIYVRGHSLREHRNAAKME-VGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIE 1509

Human  1420 LDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKR 1484
            .:.|:.|.:.:.....|.||||..||: :.:..:..||:.:..:|...::.:||.:. |.|...|
  Fly  1510 FNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSVDHATQRFIWRKLE-AVKRSGR 1572

Human  1485 AAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEVDRLQRE 1549
            ..:|||..||||.|||.|||.:|:|::..||::|.::|:......:.:::     |....:|:|.
  Fly  1573 PVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRV-----NPSDGKLKRR 1632

Human  1550 IQY-------IFPNASRQESFSSILAYKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQ 1607
            .|.       :||.|:..|:..:.|.|.| ..:|.:|:..|:::|:.::...:|:||.:|.:|::
  Fly  1633 FQQLIADMAELFPLATLHEALETCLIYHI-NINVTTLANLFYQMEKIRNEGLLEDYSITQVSLDE 1696

Human  1608 VFVELTKEQEEEDNSCGTLNST 1629
            ::..|   .:|||.:...|:||
  Fly  1697 IYRIL---NDEEDPNLVDLDST 1715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA5NP_061142.2 rim_protein <84..1618 CDD:130324 393/1743 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 5/18 (28%)
CG31213NP_732473.2 rim_protein <118..1698 CDD:130324 387/1696 (23%)

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