Protein Alignment ABCA5 and CG42816

DIOPT Version :10

• Sequence 1: NP_061142.2
• Gene: ABCA5 / 23461
• HGNCID: 35
• Length: 1642
• Species: Homo sapiens
• Sequence 2: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Alignment Length: 1612
• Identity: 403/1612 - (25%)
• Similarity: 715/1612 - (44%)
• Gaps: 323/1612 - (20%)

Human   169 WSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPR--------------- 218
            :.:||..:|.::....|:.|.     ||...|:    |:.....|...|.
  Fly    11 YKTGFLAVQQALSQVHIKHKC-----KEFNKTQ----GDIKFPPIKDLPSPPIFKSDNSSTLQDV 66

Human   219 GVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAV 283
            |:::|.::|.|....  |...||.|||.::|..|.:||:.....|::| .:.|.:|||:.   :.
  Fly    67 GIMIIVIIIFFVVVS--LTKSIVEEKELQLKVTLNLMGVGSCLQWVAW-YIQTFIIFLIG---SS 125

Human   284 IATA--SLLFPQSS---------SIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVA 337
            |.|.  .|:.|.|.         |:.:|:|..| ...::.|:.:::.|...:..:.:|.|...:|
  Fly   126 IITLFWKLVLPNSEISFMPFTHWSMALFVLLVL-SHCTICFSFLMSSLISTTYRISLVTFLALIA 189

Human   338 FGFIGLMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYP---LIIT 399
             .::..:|:..:...:.|....|.|......:.:..:...||:.||..:.||....:|   |.:.
  Fly   190 -TYLPFLILHSKGCSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVG 253

Human   400 IIMLT--LNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYW---------SKSKRNYEELSEG 453
            .|:|.  |.|...:||.:||:::.||.:|:         |..|         ::|...|..|. .
  Fly   254 YILLVMILASFLSLLLCLYLEKIRPGPYGV---------PQPWHFPCTRCCSTESLLPYSRLF-N 308

Human   454 NVNGNISFS--------EIIEPVSSEFVGKEA-IRISGIQKTYRKKGENVEALRNLSFDIYEGQI 509
            .:.|..|.:        ::|||   :.|.|.| ::|.|:.||:.|    :|.::|:|||::||||
  Fly   309 RIFGIYSAAPDEERPDLQLIEP---DPVDKIAGVQIRGLSKTFGK----MEVVKNVSFDMFEGQI 366

Human   510 TALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVE 574
            |.|:||:|.||:||:::|.|...|:.|.|.|.|..:.:  |..:|::.||:|||.::.|..|:..
  Fly   367 TVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQ--ERRQAQRCIGLCPQQNVLFKHLSSV 429

Human   575 ENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLD 639
            .::.:.:.::|:....:..|||..|..|::|..|...|:.||||.:|:||:..::.|..|:|:.|
  Fly   430 SHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICD 494

Human   640 EPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKW 704
            ||:.|:||.:|..:|.|:...|.....:.:||.:|:.::|.||..:||.|.|:|:||..|||.:.
  Fly   495 EPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV 559

Human   705 GIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSN- 768
            .....::....|.|..|.|:||:.:|:..........:.:.|.||......||.||..|:|..|
  Fly   560 DASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNI 624

Human   769 LGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAAL 833
            |||..:.:|..:||::|:....| :::.      .|....|:.|....|:.|:     :|.:...
  Fly   625 LGVRGFSLSSVSLEEIFMSFGAE-DLNS------RQSGGAEKRDDDDRDDDEE-----NEVQDGN 677

Human   834 V-STMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSFKNAVVPIKLVP 897
            | |....|:..|         |.|..:.....|..|||:                       |.|
  Fly   678 VRSCKKQWRAMM---------TKKVMALYDNKVYFLLLL-----------------------LTP 710

Human   898 DLYF---LKPGDKPHKY-------------KTSLLL----------QNSADSDISDLISFFTSQN 936
            .:|:   |....|||..             |.::||          :..||| |:.||.  ....
  Fly   711 IVYYITTLMMATKPHHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADS-IASLIK--GKLK 772

Human   937 IMVTMINDSDYVSVAPHS---------AALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYL 992
            ::|......|||.....|         .::.:...::..:...|.....|::.|:::|::.|...
  Fly   773 LIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALA 837

Human   993 YHL-NVTETIQIWSTPF-FQEITDIVFK----IELYFQAALLGIIVTAMPPYFA---MENAENHK 1048
            ..| ....:|::.|.|| .::..|.:..    |.:|    ::|.:..||..:.:   .|...:.|
  Fly   838 QELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIY----VIGYVSIAMIIFSSAVIQERVSHMK 898

Human  1049 IKAYTQLKLSGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYV 1113
            :..    ::|||....||:.....|:.:|||::                     ||::..|.||.
  Fly   899 MLQ----EVSGLEMITYWLSHLAFDMVVFFILV---------------------LALLLPLYGYA 938

Human  1114 P-----SVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEI--TFFMGYTIATILH---- 1167
            |     .|:.||.:|...         |..|:.|:.:...:|::.|  :..:|..|..||.
  Fly   939 PWYLLLCVLFFTGLAGLI---------FIYFLISMLSATFLAVSMILLSVIIGSLILMILGALAL 994

Human  1168 -----YAFCIIIPIYPLL---GCLI----------SFIKISWKNVRKNVDT-----YNPWDRLSV 1209
                 |....:..::||:   .|:.          |:|..:...:.:|:.:     .||     :
  Fly   995 IFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINP-----L 1054

Human  1210 AVISPYLQCV---LW------------IFLL-QYYEKKYGG----RSIRKDPFFRNLSTKSKNRK 1254
            |.:.|...||   .|            :||| .::|  ||.    |.....|:    |:|
  Fly  1055 AFLEPRCVCVNPMTWPDMLVMLGTAIILFLLIMFFE--YGSCVWYRCKGCCPY----SSK----- 1108

Human  1255 LPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKVATKYI 1319
                  ...||..|..|..|::.:...|....  :::|:.:.|:|.          ..::|...|
  Fly  1109 ------GSIEDPKVSREAEKIRAMDADQIGTR--ALVVNGVSKKYG----------CDQLAVNNI 1155

Human  1320 SFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYCPQINP 1384
            ||.:|....:||||||||||:|...::||:.....|.:::..||..... :.::|.:|||||.:.
  Fly  1156 SFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKR-NKAMKELGYCPQSDS 1219

Human  1385 LWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLG 1449
            .:...|.::..:::..:.|..:.|:.:...::......::||.|.:.....|.|||:..|:: .|
  Fly  1220 FFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CG 1283

Human  1450 NPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCI 1514
            ...:..|||||.|:||.:::|:|..|....:..| |.:||:|.|:|..|:|.:..|:|.|.:..:
  Fly  1284 ANSLICLDEPSAGVDPASRRHVWTIINEVAQQGK-AVLLTSHNMDEINALCSKSVILVDGSIYAM 1347

Human  1515 GTVQHLKSKFGKGYFLEIKLKDWIENLEVD-------RLQREIQYIFPNASRQE--SFSSILAYK 1570
            |:|||:|:|..||..|::     :.|::.|       :::.:|...:|||..:|  .||..|.::
  Fly  1348 GSVQHVKNKIAKGMTLKL-----VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQ 1407

Human  1571 IPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
            |.|:  .|.|:.|..:|..:.::.:|:||.||.:||..|.|:.:|:.::.::
  Fly  1408 ISKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSN 1457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA5	NP_061142.2	rim_protein	<84..1618	CDD:130324	403/1606 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1249..1268		3/18 (17%)
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	387/1525 (25%)