DRSC/TRiP Functional Genomics Resources

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Protein Alignment ABCA5 and CG8908

DIOPT Version :10

Sequence 1:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens
Sequence 2:NP_611464.3 Gene:CG8908 / 37293 FlyBaseID:FBgn0034493 Length:1626 Species:Drosophila melanogaster


Alignment Length:1805 Identity:409/1805 - (22%)
Similarity:746/1805 - (41%) Gaps:386/1805 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    13 QTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPN----KKYEEVPNIELNPMDKFT 73
            :|::.:...:|:.|:|.:......|..:..:...|::.:::..    ::.:|..:::..|:: .|
  Fly     9 KTQSSICLLWLVICKTARFQFSNTLTSVIIIVGPIVVFLVYAATALFREPQEETSVKYPPVN-IT 72

Human    74 LSNLILGYTPVTNITSSIMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPS-NFVGVVFKDSMS- 136
            .....:.|:|...:.:::::.|.  |....:.::.:.:..|:..:.:.|.: .:||:.|.||.| 
  Fly    73 TKVPYIYYSPENLVLAAVIEDVV--HDLKAVGSKAFASASELNKALIGKDTYGYVGIEFDDSFSD 135

Human   137 ---------------YELRFFPDMI-PVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASIDAAII 185
                           ..||..|.|: ..:||...|:      .:...|...||.|:||.:..|:|
  Fly   136 INELPINVTVGLRFPLHLRKNPKMVWDNTSILKHSK------MDVDYYQVEGFLVVQAKLSEALI 194

Human   186 QLKTNVSLWKELESTKAVIMGETA------VVEIDTFPRGVIL---IYLVIAFSPFGYFLAIHIV 241
            :.|           .:||::.|..      |.|:|.....|.|   ::|.:..|  ..:||..||
  Fly   195 RAK-----------NEAVVLPEVILQHYPDVAEVDRLDNRVALGGVLFLPVTIS--AAYLAQMIV 246

Human   242 AEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLY 306
            .|:...:::.|::||:....:||||.|:...|:.:.::.|.::..........||:|:|.| .:|
  Fly   247 MERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLKWRYFSLSDSSLVLFFL-LVY 310

Human   307 GLSSVFFALMLTPLFKKSKHVGI-VEFFVTVAFGFIGLMIIL---IESFPKSL-VWLFSPFCHCT 366
            .|..:..|.|::..|  |..||: |...:....|.:...::|   :.:.|::: |.|   |.:.:
  Fly   311 NLEVLTSAFMISSFF--SDTVGVQVAIVIVHLIGCLPWRLLLMGYVPTLPRTIFVCL---FLNSS 370

Human   367 FVIGIAQVMHLEDFNEGASFSNL----------TAGPYPLIITIIMLTLNSIFYVLLAVYLDQVI 421
            ..:|:.|.:..|:...|..::.|          ..||    |.:.|| ...:..:|:..|::|: 
  Fly   371 LAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHLGP----ILLFML-FGCLLRILVLAYMEQL- 429

Human   422 PGEFGLRRSSLYF-LKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEF--VGKEA------ 477
               ...:....|| ::||:|.:..|                    .|.|.:|  .|:|.      
  Fly   430 ---RSYQNRKWYFPVQPSFWCRWNR--------------------RPRSDDFDVEGQETGIRGHP 471

Human   478 --IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI 540
              :|...|:|.:.:    ..|:::|:.:.|:.:||..|||:.:||||::.:|.|...||.|..:|
  Fly   472 LIVRARNIEKVFNE----WIAVKDLNLNFYQDEITVFLGHNDSGKSTILMLLAGFLRPSAGEITI 532

Human   541 YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQ 605
            .|:.::  ....:||:.:.||||.::.|:.:....:|.....:||:.......|..|.|....:|
  Fly   533 NGYDLA--TNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLKGLNRQEASAETDKYLEIGRLQ 595

Human   606 TIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFST 670
            ...:.:.|.|..|.||.|.|...:.||.||||||||...|||..|..:|:||:..:..|..:.:|
  Fly   596 DFANTKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPAMRSNMWDLLRRERKGRCIIMAT 660

Human   671 HFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKY--CATESLSSLVKQHIPG 733
            |.|:||:::||:..|:....:...|::.||....|.|....:...|.  |....:::.::...|.
  Fly   661 HNMNEAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLICTKMDTCIVAEVTNFLQIRFPD 725

Human   734 ATLLQQNDQQLVYSLPFKDMDKFSGLFSALD---SHSNLGVISYGVSMTTLEDVFLKLEVEAEID 795
            ..|..:....:.|.||.|.:.:::.||..|:   ...||..||  |...||..|||:        
  Fly   726 IKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEIS--VCAPTLGSVFLQ-------- 780

Human   796 QADYSVFTQQPLEEEMDS-----KSFDEMEQ-----SLLILSET-----KAALVSTMSLWKQQMY 845
                       :.|||..     .|||.:..     |||.|..|     ....|...:.|:.   
  Fly   781 -----------MGEEMRQSWNRISSFDLLSSPSPMLSLLNLLPTFEVREDDGRVKCCNQWRA--- 831

Human   846 TIAKFHFFTLKRES---KSVRSVLLLLLIFFTVQIFMFLV-HHSFKNAVVPIKLVPDLYFLKPGD 906
            .:.|...|||:.:.   ..:.:.:::.|:..:..||:||| ||..:..|..:.:.|...|:.  |
  Fly   832 IVEKKRLFTLRHQKFYCMIIATPIIICLLIISFSIFIFLVDHHLSELLVTDLSIYPKAVFVI--D 894

Human   907 KP-------HKYKTSLL-----LQNSADSDISD-LISFFTSQNIMV--TMINDSDYVSVA----- 951
            .|       ..|..:::     :::::.:.|.| |::...|..:.|  |.:..:.:.|.|     
  Fly   895 SPAEGNRFERHYMANVIGQGGTVRSTSGTPIDDYLLAEMESDQVKVQHTFLAGATFDSNANSIIA 959

Human   952 ------PHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQ 1010
                  .|.:||::     ..|:||:....    ..:.:.|::..|      .:|:|       |
  Fly   960 WSNNKLKHGSALSM-----GLVYAAIGQEL----AKLDIRIVNKPY------QDTVQ-------Q 1002

Human  1011 EITDIVF--KIE---LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWIGQA 1070
            .:..:::  .||   |.|...:||..:.|:.|.....:...|      |...||:..|.||:...
  Fly  1003 AVRGLIYASTIEFAVLVFHYLVLGTAIFAVLPIVERRSKVQH------QQFSSGMSRSTYWLSHL 1061

Human  1071 VVDIPLFFIILILMLGSLLAFHYGLYFYTVKFLAVVFCLIGYVPSVILFTYIASFTFKKILNTKE 1135
            ..|. .|:|.:||.|..:.....|      ..|.|:..|:.:..|.|.|||:.      .|.:.:
  Fly  1062 SWDY-CFYIAMILPLIVVAGITIG------SVLPVIVQLLAFGFSAISFTYLL------CLMSND 1113

Human  1136 FWSFIYSVAALACIAITEITFFMGYTIATILH-------YA----FCIIIPIYPLLGCLISFIKI 1189
            |......:..:..|.:          :|..:|       ||    ..::.|.|.|...:...|::
  Fly  1114 FGKMFSIILYINMIGV----------LALFIHPKSPQTRYAVIESVLLVHPHYSLCCGMYEAIRM 1168

Human  1190 SWKNVRKNVDTYNPWDRLSVAVIS--PYLQCVLWIFL---LQYYEKKYGGRSIRKDPFFRNLSTK 1249
            |..:::          :|...:.|  .||..|::.::   |.|..|     |||.:..:      
  Fly  1169 STFSLK----------QLPYLIFSGAAYLTIVVFAWVPRRLNYVFK-----SIRNEKIY------ 1212

Human  1250 SKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKPSIMVSNLHKEYDDKKDFLLSRKVKKV 1314
                     |..:|||::|...|.::..|........  .:::.||.|.|.           ..|
  Fly  1213 ---------PSYKDEDKEVDKMRRRLAYLTTAHYAFF--PLILKNLSKRYG-----------SFV 1255

Human  1315 ATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLKCMGYC 1379
            |.:.::..:...|.:||||.||:|||:|..::||....|.|.:.:..||.:|...|.| :.:|:|
  Fly  1256 AVRSLTLDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDAS-RHVGFC 1319

Human  1380 PQINPLWPDTTLQEHFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFA 1444
            |:...|....|.::.......:.|:....:|.:::.:....:|..|:.|.:.....|.||||..|
  Fly  1320 PRELMLLSFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIA 1384

Human  1445 LSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSG 1509
            :..|. |.:..||||:.|:|..||..:| :|....:...|:.:||||.:||.|.:|..|.||..|
  Fly  1385 MGTLA-PSLMCLDEPTAGVDMHAKYEIW-SILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHG 1447

Human  1510 QLRCIGTVQHLKSKFGKGYFLEIKL----------KDWIE------------------------- 1539
            .|.|.|::..||.:|..|.|:::|:          .:|::                         
  Fly  1448 SLLCYGSLSRLKHRFNMGIFVKVKMGTRAEMDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHL 1512

Human  1540 ------------------------NLEV------DRLQREIQYIF------PNASRQESFSSILA 1568
                                    |.|:      :.|.:|::.:|      ...|.:.|:..::.
  Fly  1513 LRHHNPPVEPVKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMIT 1577

Human  1569 YKIPKEDVQSLSQSFFKLEEAKHAFAIEEYSFSQATLEQVFVELTKEQEE 1618
            :.||:..:: .|..|..:|..|....|..||.|..|.:.||::..::|.:
  Fly  1578 FCIPRGQIK-WSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQNQ 1626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA5NP_061142.2 rim_protein <84..1618 CDD:130324 398/1728 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 4/18 (22%)
CG8908NP_611464.3 rim_protein <124..1626 CDD:130324 394/1685 (23%)

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