DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA5 and Eato

DIOPT Version :9

Sequence 1:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1752 Identity:413/1752 - (23%)
Similarity:708/1752 - (40%) Gaps:343/1752 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    39 PLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLIL--GYTPVTNITSSIMQKVSTDHLP 101
            ||||:|       :..|..|          :.:..|..|::  |:..|  :|:.:...|.    |
  Fly     7 PLFFVF-------LRKNLLY----------LQRNLLPLLLICSGFAGV--LTAYLHWSVK----P 48

Human   102 DVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVS---------------SI 151
            .:....::..:.||:...|..|.|.:..::...:|..:....|::.|.               .:
  Fly    49 VLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEM 113

Human   152 YMDSRAGCSKSCEAA--------------------------------------------QYWSSG 172
            .::....|..||.|.                                            .|..||
  Fly   114 QLEMEQQCRGSCFAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSG 178

Human   173 FTVLQASIDAAIIQLKTNVSLWKELESTKAVI--MGETAVVEIDT-----FPRGVILIYLVIAFS 230
            |..||..:|...::.:   .|.|:.|   .|:  |....|:.:|:     |.....:::.|:..|
  Fly   179 FLSLQHILDKQYMKYQ---ELGKDFE---VVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLS 237

Human   231 PFGYFLAIHIVAEKEKKIKEFLKIMG----LHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLF 291
            .|    .:..|.||:..:||||.::.    |:...|:|...:.||       |||..:...:.|:
  Fly   238 SF----VVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT-------LLMIFVLVVAYLY 291

Human   292 PQSSSI---VIFLLFFLYGLSSVFFALMLTPLFKK---SKHVGIVEFFVTVAFGFIGLMIILIES 350
            ....||   .:.:||.||.||::.:|.:::..|..   :|..|:....:..||.|       :.|
  Fly   292 KALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSF-------VRS 349

Human   351 FPKSLVWLFSPFCHCTFVIGI------AQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIF 409
            :..||.  |..|...||:.|:      :......:|.....|..:.:....:....::|...|..
  Fly   350 WATSLA--FVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFL 412

Human   410 YVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFV- 473
            |.:|..||..|.||..||:|...:||.|..:.|.:||                        |:. 
  Fly   413 YAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRN------------------------EYTT 453

Human   474 ---GKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535
               |..||.|:.:.|.::....:.....||:..|...:||.||||:|.||:|:||::.||.|...
  Fly   454 TPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDS 518

Human   536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600
            |...:...|     ::...|.:||.|||..:....:|..::|...|.::|...::......:.|.
  Fly   519 GKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLK 578

Human   601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665
            .|.:...::...|.||||.||:||||||:.||.||::||||::|:|..||..:|::|...:..:.
  Fly   579 KLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKA 643

Human   666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATE-SLSSLVKQ 729
            .:.:||:|:||::|.|...:::.|.|:.:||.:.||.|.||||||.:.|:.:.:.| .:..::..
  Fly   644 VLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHH 708

Human   730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHS-NLGVISYGVSMTTLEDVFLKLEVEAE 793
            .:|.|.:|...:..:...||:...:.|:.:...|::.| .||:.:..::.|:||||||:  ...|
  Fly   709 FVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR--CAGE 771

Human   794 IDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAAL-----VSTMSLWKQQMYTIAKFHFF 853
            .||.|                :.|.......:|:..|...     .....||....|  .|:.|.
  Fly   772 QDQVD----------------TPDGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFY--KKWTFI 818

Human   854 TLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSF----KNAVVPIKLVP----DLYFLKP-GDKPH 909
                 |......|::|.|.|.......||.|:.    ....:|:||..    .:|...| |...|
  Fly   819 -----SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAH 878

Human   910 KYK-----------TSLLLQNSADSDIS--------DLISFFTSQNI-MVTMINDSDYVSVAPHS 954
            ..:           |:..:.....:|:.        |.::.|..|.| ::.|.......|..|  
  Fly   879 LEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTP-- 941

Human   955 AALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDI-VFK 1018
             .:.:.:|...|           :|...|:|::.:..|........|.....|..:.::|| ..:
  Fly   942 -TIEIFYSGNRY-----------HSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSR 994

Human  1019 IELYFQAALLGIIVTAMPPYFA----MENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFI 1079
            :|.|.....:|:.....  ||.    .|.|...|       :|..:....||......|: |..|
  Fly   995 LEYYAVIVPIGMFFFMF--YFISLPFREYANGFK-------QLQTMSRFTYWFAHFTFDM-LILI 1049

Human  1080 ILILMLGSLLAFHYGLYFYTVKFL-AVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSV 1143
            .:.:.|.||.:.......||...| .:|..:..|..|.:...|.....||.|.....:...:..|
  Fly  1050 FVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIV 1114

Human  1144 AALACIAITEITFFMGYTIATILH---YAFCIIIPIYPLLGCLISFIKISWKNVRKNV------- 1198
            :|:|.: ||.     ....|..||   .||...:|.:.|        ...::.:.:|.       
  Fly  1115 SAIAPL-ITS-----SNAAAMKLHETKIAFLCFLPDFNL--------NHQFRIINENFITRRHPA 1165

Human  1199 --------DTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNR-- 1253
                    ||:..:......::..:...||        |.||..|.|....:......|..|.  
  Fly  1166 LIKGLISQDTFFAYATAVGVMVMAFFTIVL--------EHKYLRRRIHDGIWEWAFQRKKYNSTG 1222

Human  1254 KLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKP----SIMVSNLHKEYDDKKDFLLSRKVKKV 1314
            .||..|.:  |.:|...|..:|.:|:      :.|    |::|.||.|.|.|           |:
  Fly  1223 TLPSTPIS--EIDDCAREEKRVTDLI------KDPLNDHSLIVHNLRKRYGD-----------KL 1268

Human  1315 ATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLK---CM 1376
            |...:||...:||..||||.|||||::...::..::....|.:.:........|    ||   ..
  Fly  1269 AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHE----LKYREYF 1329

Human  1377 GYCPQINPLWPDTTLQEHFEIYGAVKGMS------ASDMKEVISRITHALDLKEHLQKTVKKLPA 1435
            |||||.:.|....|.::.......::|:|      .:..||.:......:.|.::.:..|:....
  Fly  1330 GYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSG 1394

Human  1436 GIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500
            |.||||..|::|:|.|.:.|||||:||:||.:::.:|:.|:. |:.:.|..:||:|.|:|.|.:|
  Fly  1395 GTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKDRTVVLTSHSMDECEELC 1458

Human  1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK-DWIENLEVDRLQREIQYIFPNASRQESFS 1564
            :|:|||..|:.:|:..:..||..  .|:.:::|:| |....:.|..:...::..||....:||.:
  Fly  1459 NRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHA 1521

Human  1565 SILAYKIPKEDVQSLSQSFFKLEEA----KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622
            ..|.|.:..::...|..|.||:.|.    :.:..:.:||.::.|||.:|::..:|.:.:..|
  Fly  1522 GTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTS 1583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA5NP_061142.2 ABC2_membrane_4 202..403 CDD:289500 49/223 (22%)
ABC2_membrane_3 <214..416 CDD:289468 50/222 (23%)
CcmA 476..788 CDD:224054 102/313 (33%)
ABC_subfamily_A 478..701 CDD:213230 73/222 (33%)
ABC2_membrane_3 <943..1224 CDD:289468 56/304 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 6/20 (30%)
CcmA 1290..1615 CDD:224054 97/338 (29%)
ABC_subfamily_A 1290..1521 CDD:213230 73/239 (31%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 37/155 (24%)
CcmA 460..767 CDD:224054 101/311 (32%)
ABC_subfamily_A 461..679 CDD:213230 73/222 (33%)
ABC2_membrane_3 <937..1117 CDD:289468 40/203 (20%)
ABC_subfamily_A 1255..1479 CDD:213230 73/239 (31%)
drrA 1262..1573 CDD:130256 94/328 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148356
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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