DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA6 and Eato

DIOPT Version :9

Sequence 1:NP_525023.2 Gene:ABCA6 / 23460 HGNCID:36 Length:1617 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1755 Identity:409/1755 - (23%)
Similarity:737/1755 - (41%) Gaps:356/1755 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     3 MKQKSVYQQTK----ALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSS----MRNVQFPGM 59
            :::..:|.|..    .|:|..|..    ...:.|.|.:..:|.. |..|.:.    :|.:.||| 
  Fly    13 LRKNLLYLQRNLLPLLLICSGFAG----VLTAYLHWSVKPVLHQ-INQFEAKNEMVLRELYFPG- 71

Human    60 APQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLK-GTSVIG---APNKTHMDEILLEN 120
                 ..:|       .:.|:|||...:.||:      ||: ...:|.   .||.... |:.||.
  Fly    72 -----NELD-------YIYYSPISPNVEDIMD------LLRVDLGIIPERLRPNNNSF-EMQLEM 117

Human   121 LPYAMGIIF------------NETFSYKLIFFQGYNSP---LWKEDFSAHCWDGYGEFSCTLTKY 170
            .....|..|            :..|.|.|...|...||   ...::...|..|.        ..|
  Fly   118 EQQCRGSCFAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQIDD--------DDY 174

Human   171 WNRGFVALQTAINTAIIE----------ITTNHPVMEELMSVTAITMKTLPFITK--NLLHNEMF 223
            ...||::||..::...::          :.::.|.||    |.::....|.:...  ::|.|.:.
  Fly   175 IRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNME----VISMDSHRLTYFGTLCSILFNVVL 235

Human   224 ILFFLLHFSPLVYFISLNVTKER----KKSKNLMKMMG-LQDSAFWLSWGLIYAGFIFIISIFVT 283
            :..|::.|           .:|:    |:..||:..|. |....|:|...:.|.    ::.|||.
  Fly   236 LSSFVVPF-----------VEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT----LLMIFVL 285

Human   284 IIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLL------KKAVLTNLVV---FLLTLFW 339
            ::....:.:....|..:.:||.||.||.::..:|:|:..      |...|..|::   |.....|
  Fly   286 VVAYLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSW 350

Human   340 G------CLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIA 398
            .      |.....|.|.        |:|...|:......:...:|      :|.....:|.||.:
  Fly   351 ATSLAFVCFSTNTFLEG--------LDIFQTFSNKRKNREFGAVD------VFRVIKSNSSTMFS 401

Human   399 TFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDD 463
            .:.:|:....:|.:|..|...:.|..........|||:..:..:.||                ::
  Fly   402 VYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQR----------------NE 450

Human   464 YFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILN 528
            |  ...|  :|..||.|..:.|:::...........|...|...:||.:|||:||||::::|::.
  Fly   451 Y--TTTP--RGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIM 511

Human   529 GLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQ 593
            ||.....|.:.:.::     :|:...|.:.|.|||.:|....:|..::|..||:::|....:...
  Fly   512 GLVPKDSGKIIVCSE-----RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARD 571

Human   594 EVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLR 658
            .....|.:|.:.:.::...|:||.|.||:|:.||.|.|:.:|::||||::|||..||.::|.:|.
  Fly   572 WADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILL 636

Human   659 ERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPE-Q 722
            ..|.:..:|.:|..|:||::|.|...|::||:|:..||.:.|||:.|:||.|.|..|:..:.| :
  Fly   637 NLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVE 701

Human   723 ITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLD-KCSDQGVTGYDISMSTLNEVFM 786
            |...|.|.:|.|::.......:...||....|.|..:...|: :..:.|:....::.::|.:||:
  Fly   702 IMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFL 766

Human   787 KLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQ 851
            :..|    |||  ||: ..|....:...|||  :..:|......||:::.: |:...::..:..:
  Fly   767 RCAG----EQD--QVD-TPDGSRNDAPLLAH--YKRLQDHPPHRGLFQLWM-AVFYKKWTFISNE 821

Human   852 TKVLLTLLLVFGIAIFPLIVENIMYAML---NE-----KIDWEFKNELYFLSP----GQLPQEPR 904
            ....|.:|.:..:.:|..|:  :|:||.   ||     |:.......:|..:|    ..|.|:.|
  Fly   822 WLYTLIMLCIPFVCVFGAIL--VMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLR 884

Human   905 TSLLI--------------------INNTESNIEDFIKSLKHQNILLEVDDFENRNGTDG----- 944
            ..:.:                    ::....|:.||:     :.::..:|.:....||..     
  Fly   885 QQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFL-----EQVIGIIDMYGGGRGTSDTPTIE 944

Human   945 LSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFN-----HTQHIRI-----ES 999
            :.|:|                   .|.|....|:|::.:.:|::..     .|.::.|     :.
  Fly   945 IFYSG-------------------NRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDI 990

Human  1000 SPFPLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALV 1064
            ||..|.:..:.  :|.|.||......|: |:      .:| .|...||.....:|  ||......
  Fly   991 SPSRLEYYAVI--VPIGMFFFMFYFISL-PF------REY-ANGFKQLQTMSRFT--YWFAHFTF 1043

Human  1065 DVSFFILILLLMYLIFYIENMQYLLITSQI-----VFALVIVTPGYAASLVFFIYMISFIFRKRR 1124
            |      :|:|:::...:.::|.|::.|::     :..:|:....|..|.:..:|.:...|:   
  Fly  1044 D------MLILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFK--- 1099

Human  1125 KNSGLWSFYFFFASTIMFSITLINHFDLSILITTMV--LVPS---------YTLLGFKTFLEVRD 1178
                              ||:.|:.:.|.:||.:.:  |:.|         .|.:.|..||...:
  Fly  1100 ------------------SISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFN 1146

Human  1179 QEHYREFPEANF----------ELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFR 1233
            ..|.......||          .|.:.|....:......::..|....:|.|..::|:. |.::.
  Fly  1147 LNHQFRIINENFITRRHPALIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIH-DGIWE 1210

Human  1234 ISPQSRDAKPN-----PEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSC 1293
            .:.|.:  |.|     |..||.|.:|...|..| .|.|....|::..:|:.: |.|.|.      
  Fly  1211 WAFQRK--KYNSTGTLPSTPISEIDDCAREEKR-VTDLIKDPLNDHSLIVHN-LRKRYG------ 1265

Human  1294 FSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGH--- 1355
                 .|:|...:||...:||..||||.|||||:|:.:||:.......|.:.:|| :.:..|   
  Fly  1266 -----DKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKG-ADIREHELK 1324

Human  1356 ----LGYCPQENVLWPMLTLREHLEVYAAVKGL--RKADARLAIARLVSAF--KLH--EQLNVPV 1410
                .|||||.:.|...:|..:.|...|.::||  |:.|...:....|..:  |:|  :...|.|
  Fly  1325 YREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQV 1389

Human  1411 QKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAE 1475
            :..:.|..|||...::::|...::|||||:||:||..::.:||.|:. .:..:|.|:||:|::.|
  Fly  1390 RHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKDRTVVLTSHSMDE 1453

Human  1476 AEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVK---ETSQVTLVHTEILKL-FPQAAG 1536
            .|.||:|:|||..|:.:|:.:|..||...|  :.::||:|   ||.......|..||. ||....
  Fly  1454 CEELCNRLAIMAHGKFKCLNNICALKRLSG--FTIKLKMKADTETEMNVSTITGTLKSEFPGLEL 1516

Human  1537 QERYSSLLTYKLPV-------ADVYPLSQTF--HKLEAVKHNFNLEEYSLSQCTLEKVFLELSKE 1592
            :|.::..|||.:..       :.|:.:::.:  .:|.|:     :.:||:::||||.:||:..:|
  Fly  1517 RESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSAL-----VADYSVNECTLEDIFLKFERE 1576

Human  1593  1592
              Fly  1577  1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA6NP_525023.2 ABC2_membrane_3 34..375 CDD:289468 79/395 (20%)
CcmA 476..788 CDD:224054 94/313 (30%)
ABC_subfamily_A 478..701 CDD:213230 69/222 (31%)
ABC2_membrane_3 866..1167 CDD:289468 63/363 (17%)
CcmA 1275..1592 CDD:224054 105/342 (31%)
ABC_subfamily_A 1296..1501 CDD:213230 73/217 (34%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 33/156 (21%)
CcmA 460..767 CDD:224054 94/311 (30%)
ABC_subfamily_A 461..679 CDD:213230 69/222 (31%)
ABC2_membrane_3 <937..1117 CDD:289468 43/237 (18%)
ABC_subfamily_A 1255..1479 CDD:213230 77/237 (32%)
drrA 1262..1573 CDD:130256 103/330 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148348
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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