DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATP1B4 and CG33310

DIOPT Version :9

Sequence 1:	NP_001135919.1	Gene:	ATP1B4 / 23439	HGNCID:	808	Length:	357	Species:	Homo sapiens
Sequence 2:	NP_995718.2	Gene:	CG33310 / 2768910	FlyBaseID:	FBgn0053310	Length:	876	Species:	Drosophila melanogaster

Alignment Length:	257	Identity:	46/257 - (17%)
Similarity:	92/257 - (35%)	Gaps:	78/257 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   157 RPFAHSLNFNFNVSEPDTWQH-------YVISLNGFLQGYNDSLQEEMNVDCP------PGQYFI 208
            |.|.:.::..:.:..|..|.:       |::.:..|...:.|.::::.:...|      |...|.
  Fly   586 RLFFNKIHGKYKLRRPSHWLYTLVFSVLYILFVIIFSMAWFDFIKDDASRKVPMIKMAQPFISFT 650

Human   209 QDGNEDEDKKACQF----KRSFLKNCSGL--------------------EDPTFGYSTGQPCILL 249
            ..|.. .:.||..|    ....::..:|:                    .:..|||.:|:||:.|
  Fly   651 PIGPR-TNPKAVSFDPRNSTEVMEKYAGIMALLEKYGDYGHNPRFGTCTANEKFGYPSGEPCVFL 714

Human   250 KMNRIVGFR--PELGDPVKVSCKVQ----------------------------RGDENDIRSISY 284
            |:|||:||:  |.:.....|..|:.                            |.|::....|.:
  Fly   715 KVNRIIGFKTEPYINSDELVKAKIDEVEFTALKRLLENTTTEEGHLNRTWITCRSDKDKNVLIEF 779

Human   285 YPESA--------SFDLRYYPYYGKLTHV--NYTSPLVAMHFTDVVKNQAVPVQCQLKGKGV 336
            :||.|        ...:.|....||.:..  |..:.:||:...::..|:.|.:.|::..:.:
  Fly   780 HPEPAIRTEYTDIEEKIEYIANEGKKSFFGPNDVNRIVALKIKNLKANERVHINCKMWAQNI 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP1B4	NP_001135919.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..80
ATP1B4	NP_001135919.1	Na_K-ATPase	82..351	CDD:306737	46/257 (18%)
CG33310	NP_995718.2	Na_K-ATPase	<703..847	CDD:298651	31/139 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950