DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TARDBP and PAB1

DIOPT Version :9

Sequence 1:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_011092.1	Gene:	PAB1 / 856912	SGDID:	S000000967	Length:	577	Species:	Saccharomyces cerevisiae

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	134/384 - (34%)	Gaps:	116/384 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    69 GNLVYVVNY--PKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVL 131
            |..:||..:  .|:...:::||.|           ..::|.|..:..:||::..:|.|:.||.::
Yeast   193 GQEIYVAPHLSRKERDSQLEETKA-----------HYTNLYVKNINSETTDEQFQELFAKFGPIV 246

Human   132 MVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK--------------- 181
            ...::|| ..|..||||||.:.::|..||.:...:       |.:|...|
Yeast   247 SASLEKD-ADGKLKGFGFVNYEKHEDAVKAVEALN-------DSELNGEKLYVGRAQKKNERMHV 303

Human   182 -QSQDEPLRSRK--------VFVGRCTEDMTEDELREFFSQYGDVMDVFIPK----PFRAFAFVT 233
             :.|.|..|..|        :||....:.:.:::|.|.|:.||.:....:.:    ..:.|.||.
Yeast   304 LKKQYEAYRLEKMAKYQGVNLFVKNLDDSVDDEKLEEEFAPYGTITSAKVMRTENGKSKGFGFVC 368

Human   234 FADDQIAQSLCGE--DLIIKGISVHISNAEPKHNSNRQLER-----------------SGRFGGN 279
            |:..:.|.....|  ..|:.|..::::.|:.|.....||.:                 :....|.
Yeast   369 FSTPEEATKAITEKNQQIVAGKPLYVAIAQRKDVRRSQLAQQIQARNQMRYQQATAAAAAAAAGM 433

Human   280 PGGFGNQGGFG--NSRGGGAGLGNNQGSNMGGGM----------NFGAFSINPAMMAAAQAALQS 332
            ||.|.....:|  ..||......|.|..|..|||          |...:.:.|
Yeast   434 PGQFMPPMFYGVMPPRGVPFNGPNPQQMNPMGGMPKNGMPPQFRNGPVYGVPP------------ 486

Human   333 SWGMMGMLASQQNQSG-PSGNNQNQGNMQREPNQAFG----------SGNNSYSGSNSG 380
                         |.| |...|.|....|::..||.|          :.|...:|..:|
Yeast   487 -------------QGGFPRNANDNNQFYQQKQRQALGEQLYKKVSAKTSNEEAAGKITG 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118	3/7 (43%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		3/15 (20%)
		RRM1_TDP43	105..181	CDD:240767	22/75 (29%)
		RRM2_TDP43	191..261	CDD:240768	16/83 (19%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		39/211 (18%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		11/60 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373		10/42 (24%)
PAB1	NP_011092.1	PABP-1234	38..559	CDD:130689	80/384 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910