DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TARDBP and HRB1

DIOPT Version :9

Sequence 1:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_014394.2	Gene:	HRB1 / 855728	SGDID:	S000004949	Length:	454	Species:	Saccharomyces cerevisiae

Alignment Length:	151	Identity:	38/151 - (25%)
Similarity:	68/151 - (45%)	Gaps:	29/151 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    87 ETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKT--GHSKGFGF 149
            |.|::...||.|  ..::.:.|..|.:.:|.:||.|:||..|:|    |:.|:.|  ||.:|.|.
Yeast   146 ELDSTYEEKVNR--NYSNSIFVGNLTYDSTPEDLTEFFSQIGKV----VRADIITSRGHHRGMGT 204

Human   150 VRFTEYETQVKVMSQRHMIDGR-WCDCKL--------PNSKQSQDEPL---------RSRKVFVG 196
            |.||..:...:.:.|   .||. :.|.|:        |::...:.:.|         ::.:|.|.
Yeast   205 VEFTNSDDVDRAIRQ---YDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVK 266

Human   197 RCTEDMTEDELREFFSQYGDV 217
            .....:....|::.|.:.|:|
Yeast   267 NLPASVNWQALKDIFKECGNV 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		4/10 (40%)
		RRM1_TDP43	105..181	CDD:240767	26/86 (30%)
		RRM2_TDP43	191..261	CDD:240768	6/27 (22%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373
HRB1	NP_014394.2	PRK12678	<29..>85	CDD:237171
		RRM1_HRB1_GBP2	160..236	CDD:410184	25/82 (30%)
		RRM2_HRB1_GBP2	262..334	CDD:410185	6/26 (23%)
		RRM3_HRB1_GBP2	374..452	CDD:410186
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910