Protein Alignment TARDBP and HRB1

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_014394.2
• Gene: HRB1 / 855728
• SGDID: S000004949
• Length: 454
• Species: Saccharomyces cerevisiae
• Alignment Length: 151
• Identity: 38/151 - (25%)
• Similarity: 68/151 - (45%)
• Gaps: 29/151 - (19%)

Human    87 ETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKT--GHSKGFGF 149
            |.|::...||.|  ..::.:.|..|.:.:|.:||.|:||..|:|    |:.|:.|  ||.:|.|.
Yeast   146 ELDSTYEEKVNR--NYSNSIFVGNLTYDSTPEDLTEFFSQIGKV----VRADIITSRGHHRGMGT 204

Human   150 VRFTEYETQVKVMSQRHMIDGR-WCDCKL--------PNSKQSQDEPL---------RSRKVFVG 196
            |.||..:...:.:.|   .||. :.|.|:        |::...:.:.|         ::.:|.|.
Yeast   205 VEFTNSDDVDRAIRQ---YDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVK 266

Human   197 RCTEDMTEDELREFFSQYGDV 217
            .....:....|::.|.:.|:|
Yeast   267 NLPASVNWQALKDIFKECGNV 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		4/10 (40%)
		RRM1_TDP43	105..178	CDD:409760	25/83 (30%)
		RRM2_TDP43	191..261	CDD:409761	6/27 (22%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373
HRB1	NP_014394.2	PRK12678	<29..>85	CDD:237171
		RRM1_HRB1_GBP2	160..236	CDD:410184	25/82 (30%)
		RRM2_HRB1_GBP2	262..334	CDD:410185	6/26 (23%)
		RRM3_HRB1_GBP2	374..452	CDD:410186