DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TARDBP and HRP1

DIOPT Version :9

Sequence 1:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_014518.1	Gene:	HRP1 / 853997	SGDID:	S000005483	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	452	Identity:	123/452 - (27%)
Similarity:	183/452 - (40%)	Gaps:	97/452 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     9 EDENDEPIEIPSEDDGTVLLSTVTAQFPGACGL----------RYRNPVSQCMRGVRLVEGILHA 63
            |..|::......::..|...:...|...|..||          :::.|.||             :
Yeast    85 EGSNEDTKNEKKQESATSANANANASSAGPSGLPWEQLQQTMSQFQQPSSQ-------------S 136

Human    64 PDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFG 128
            |..      ..|...|:.:.|.|.:            :::..:.:.||.|.|||.:|:|||..:|
Yeast   137 PPQ------QQVTQTKEERSKADLS------------KESCKMFIGGLNWDTTEDNLREYFGKYG 183

Human   129 EVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKV 193
            .|..:::.||..||.|:||||:.|.:..:..:|:..:|::||:..|   |.....:||..::.|:
Yeast   184 TVTDLKIMKDPATGRSRGFGFLSFEKPSSVDEVVKTQHILDGKVID---PKRAIPRDEQDKTGKI 245

Human   194 FVGRCTEDMTEDELREFFSQYGDVMD--VFIPK---PFRAFAFVTFADDQIAQSLCGEDLI-IKG 252
            |||....|:...|..|||||:|.::|  :.:.|   ..|.|.|||:........:|....| .|.
Yeast   246 FVGGIGPDVRPKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKD 310

Human   253 ISVHISNAEPKHNSNRQLERSGRFGGN-----PGGFGNQGGFGNSRGGGAGLGNNQGSN-MGGGM 311
            ..:.|..|||:|...:.....|..|||     .|.|||||.|           |....| |.||.
Yeast   311 RKIEIKRAEPRHMQQKSSNNGGNNGGNNMNRRGGNFGNQGDF-----------NQMYQNPMMGGY 364

Human   312 NFGAFSINPAMMAAAQAALQSSWGMM----GM----LASQQNQS----------GPSGNNQNQGN 358
            |   ..:||..|......:|..:..|    ||    :..||.|.          .|:....||
Yeast   365 N---PMMNPQAMTDYYQKMQEYYQQMQKQTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQ-- 424

Human   359 MQREPNQAFGSGNNSYSGSNSGAAIGW-GSASNAGSGSG----FNGGFGSSM--DSKSSGWG 413
            .|::.|...||...|.|.:|....:.. |:.||..|||.    .||..|.|.  |..:||:|
Yeast   425 PQQDSNATQGSPAPSDSDNNKSNDVQTIGNTSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118	12/77 (16%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		2/15 (13%)
		RRM1_TDP43	105..181	CDD:240767	28/75 (37%)
		RRM2_TDP43	191..261	CDD:240768	23/75 (31%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		66/235 (28%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		15/46 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373		10/41 (24%)
HRP1	NP_014518.1	PABP-1234	<144..463	CDD:130689	102/349 (29%)
		RRM1_Hrp1p	161..236	CDD:409991	28/77 (36%)
		RRM2_Hrp1p	244..321	CDD:409767	25/76 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910