DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and Hrb87F

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_476806.2 Gene:Hrb87F / 48535 FlyBaseID:FBgn0004237 Length:385 Species:Drosophila melanogaster


Alignment Length:321 Identity:104/321 - (32%)
Similarity:142/321 - (44%) Gaps:35/321 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   106 LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTE-YETQVKVMSQRHMID 169
            |.:.||.::||:..||.:|..:|.::.|.|.||.||..|:||||:.::: |.......::.|.||
  Fly    26 LFIGGLDYRTTDDGLKAHFEKWGNIVDVVVMKDPKTKRSRGFGFITYSQSYMIDNAQNARPHKID 90

Human   170 GRWCDCKLPNSKQSQDEP---LRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPK-----PF 226
            ||..:.|....:|..|.|   ...:|:|||...:|..|:.|||:|..:|.::.|.|..     ..
  Fly    91 GRTVEPKRAVPRQEIDSPNAGATVKKLFVGGLRDDHDEECLREYFKDFGQIVSVNIVSDKDTGKK 155

Human   227 RAFAFVTFAD-DQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFG 290
            |.|||:.|.| |.:.:.:..:...||..::.:..|..|.:.:||....||.|...||.|.||..|
  Fly   156 RGFAFIEFDDYDPVDKIILQKTHSIKNKTLDVKKAIAKQDMDRQGGGGGRGGPRAGGRGGQGDRG 220

Human   291 NSRGGGAGLG-NNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSG--- 351
            ...||..|.. .|.|.|.||....|.|..:.......|......|          ||.|.||   
  Fly   221 QGGGGWGGQNRQNGGGNWGGAGGGGGFGNSGGNFGGGQGGGSGGW----------NQQGGSGGGP 275

Human   352 -NNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSG 411
             |||..||     ....|.|...|.|.||..:  ||  .|.|.|.| .||||:.......|
  Fly   276 WNNQGGGN-----GGWNGGGGGGYGGGNSNGS--WG--GNGGGGGG-GGGFGNEYQQSYGG 326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98
RRM1_TDP43 105..178 CDD:409760 27/72 (38%)
RRM2_TDP43 191..261 CDD:409761 22/75 (29%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 63/207 (30%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 0/10 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 15/42 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 12/35 (34%)
Hrb87FNP_476806.2 RRM1_hnRNPA_like 25..102 CDD:409992 27/75 (36%)
RRM_SF 116..188 CDD:473069 22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

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