DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and trv

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_001163754.3 Gene:trv / 43362 FlyBaseID:FBgn0085391 Length:651 Species:Drosophila melanogaster


Alignment Length:352 Identity:80/352 - (22%)
Similarity:129/352 - (36%) Gaps:85/352 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    86 DETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFV 150
            |..|:...::....:.|...:.|..|..:...|.|:|.|:.|||:...:|.:|.:|..|||:|||
  Fly   294 DMEDSDEEMEYMPPLHKQFHIFVGDLSSEIETQQLREAFTPFGEISDCRVVRDPQTLKSKGYGFV 358

Human   151 RF---TEYETQVKVMSQRHM----IDGRWCDCKLPNSKQ-----------SQDEPLRSRKVFVGR 197
            .|   :|.|:.:..|:.:.:    |...|...|.|.||:           :|..| .:..|:||.
  Fly   359 SFIKKSEAESAITAMNGQWLGSRSIRTNWATRKPPASKENIKPLTFDEVYNQSSP-SNCTVYVGG 422

Human   198 CTEDMT---EDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHIS- 258
            ....:|   |:.|::.|:.||.:.::.:.|. :.:|||.|:..:.|....        :.||.: 
  Fly   423 VNSALTALSEEVLQKTFAPYGAIQEIRVFKD-KGYAFVRFSTKEAATHAI--------VGVHNTE 478

Human   259 -NAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAM 322
             ||:|...|                :|.:.|..|:....|....|..:....|..:|   :..|.
  Fly   479 INAQPVKCS----------------WGKESGDPNNAQTIATQALNSAAAAAAGFPYG---VGAAA 524

Human   323 MAAA---QAALQSSW------------------GMMGMLASQQNQ--SGPSGNNQNQGNMQREPN 364
            .|||   |.|....|                  ......|:.|||  .|..|.:..|        
  Fly   525 AAAAYGQQLAATGCWYSPTPTYPASSATAAAVTPAAASAAAVQNQFLQGIQGYHFGQ-------- 581

Human   365 QAFGSGNNSYSGSNSGAAIGWGSASNA 391
              :|.....|.|........|...:.|
  Fly   582 --YGGYQQGYMGMGVQIPATWQGVTQA 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98 2/11 (18%)
RRM1_TDP43 105..178 CDD:409760 25/79 (32%)
RRM2_TDP43 191..261 CDD:409761 18/74 (24%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 38/201 (19%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 1/10 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 6/41 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 8/33 (24%)
trvNP_001163754.3 RRM2_TIA1_like 313..387 CDD:409789 23/73 (32%)
RRM3_TIA1_like 416..489 CDD:409790 21/97 (22%)
Blue background indicates that the domain is not in the aligned region.

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