DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and msi

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_733108.2 Gene:msi / 43087 FlyBaseID:FBgn0011666 Length:634 Species:Drosophila melanogaster


Alignment Length:387 Identity:97/387 - (25%)
Similarity:150/387 - (38%) Gaps:90/387 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   106 LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMS-QRHMID 169
            |.|.||.|:|:...|||||:.||.|..|.:.||..|..|:||||:.|.|..|..||:. ..|.:|
  Fly   205 LFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQEPCTVEKVLKVPIHTLD 269

Human   170 GRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFI-----PKPFRAF 229
            |:..|.|....|....:..:::|:|||..::|.:.:|::.:|||:|.|.:..:     .|..|.|
  Fly   270 GKKIDPKHATPKNRPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPVEETVMLMDQQTKRHRGF 334

Human   230 AFVTFADDQIAQSLCGEDL-IIKGISVHISNAEPK------------------------------ 263
            .||||.::.:...:|.... .||...|....|:||                              
  Fly   335 GFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLLQKRIMLGTLGVQLPTAPGQL 399

Human   264 -----------------HNSNRQL---------ERSGRFGGNP---------GGFGNQGGFGNSR 293
                             .|..:.|         :::.....||         ....||.|||.  
  Fly   400 IGARGAGVATMNPLAMLQNPTQLLQSPAAAAAAQQAALISQNPFQVQNAAAAASIANQAGFGK-- 462

Human   294 GGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLAS----QQNQSGPSGNNQ 354
                 |...........:.:..:|| ||..|.|.|||..:.....:.|:    ||.|.....:.|
  Fly   463 -----LLTTYPQTALHSVRYAPYSI-PASAATANAALMQAHQAQSVAAAAHHHQQQQQQQHHHQQ 521

Human   355 NQGN-----MQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSG 411
            ...|     .|::......:.:|..|.::|.||.. ..|:||.:|:|..|....:..::.:|
  Fly   522 QTHNAHVAAAQQQQQSHHNAVSNPASQAHSAAAAA-ALAANAANGAGAAGAHSLAAAAQQAG 582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98
RRM1_TDP43 105..178 CDD:409760 33/72 (46%)
RRM2_TDP43 191..261 CDD:409761 22/75 (29%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 53/276 (19%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 1/11 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 12/106 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 7/40 (18%)
msiNP_733108.2 RRM_SF 204..278 CDD:473069 33/72 (46%)
RRM2_MSI 292..365 CDD:240769 22/72 (31%)
Blue background indicates that the domain is not in the aligned region.

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