DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and Rbp6

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_001097631.1 Gene:Rbp6 / 39919 FlyBaseID:FBgn0260943 Length:499 Species:Drosophila melanogaster


Alignment Length:265 Identity:66/265 - (24%)
Similarity:119/265 - (44%) Gaps:31/265 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   106 LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQ-RHMID 169
            :.:.||.|:|:.:.|::||..:|::....|.||..|..|:|||||.|::..:..||::| .|.:|
  Fly    31 MFIGGLSWQTSPESLRDYFGRYGDISEAMVMKDPTTRRSRGFGFVTFSDPNSVDKVLTQGTHELD 95

Human   170 GRWCDCKLPNSKQSQDEPL-RSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFI-----PKPFRA 228
            |:..|.|:...:::..:.: |::|:|||..:...|.::::.:|.|:|.:.|..:     ....|.
  Fly    96 GKKVDPKVAFPRRAHPKMVTRTKKIFVGGLSAPTTLEDVKSYFEQFGPIEDAMLMFDKQTNRHRG 160

Human   229 FAFVTFADDQIAQSLCGEDLIIKGIS---VHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFG 290
            |.||||..:.:...:|  ::....|:   |....|:||...            .|.........|
  Fly   161 FGFVTFQSEDVVDKVC--EIHFHEINNKMVECKKAQPKEVM------------LPANLAKTRAAG 211

Human   291 NSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQN 355
            .|..|...:..:..::.....:..|..:.|:.:|||.:.||..       ..||.|.......|.
  Fly   212 RSAYGELVVWGSSHAHSTAATSAAAAGLLPSSLAAAASVLQQQ-------QQQQQQQQQQQQQQQ 269

Human   356 QGNMQ 360
            |.:.|
  Fly   270 QHHQQ 274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98
RRM1_TDP43 105..178 CDD:409760 27/72 (38%)
RRM2_TDP43 191..261 CDD:409761 18/77 (23%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 30/153 (20%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 1/10 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 6/41 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 6/20 (30%)
Rbp6NP_001097631.1 RRM1_MSI 30..105 CDD:409990 27/73 (37%)
RRM2_MSI 119..192 CDD:240769 18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

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