| Sequence 1: | NP_031401.1 | Gene: | TARDBP / 23435 | HGNCID: | 11571 | Length: | 414 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261874.1 | Gene: | cocoon / 39665 | FlyBaseID: | FBgn0036496 | Length: | 318 | Species: | Drosophila melanogaster |
| Alignment Length: | 323 | Identity: | 158/323 - (48%) |
|---|---|---|---|
| Similarity: | 215/323 - (66%) | Gaps: | 23/323 - (7%) |
- Green bases have known domain annotations that are detailed below.
|
Human 4 YIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP--DA 66
Human 67 GWGNLVYVVNYPKDNKRKMDETDASSAVKVKR--AVQKTSDLIVLGLPWKTTEQDLKEYFSTFGE 129
Human 130 VLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK-QSQDEPLRSRKV 193
Human 194 FVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHIS 258
Human 259 NAEPKHNSNR-QLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINP 320 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TARDBP | NP_031401.1 | TDP43_N | 4..77 | CDD:376118 | 38/74 (51%) |
| Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 | 82..98 | 4/15 (27%) | |||
| RRM1_TDP43 | 105..181 | CDD:240767 | 47/75 (63%) | ||
| RRM2_TDP43 | 191..261 | CDD:240768 | 45/69 (65%) | ||
| Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 | 216..414 | 43/106 (41%) | |||
| Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 | 239..250 | 3/10 (30%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 261..303 | 7/42 (17%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 341..373 | ||||
| cocoon | NP_001261874.1 | RRM1_TDP43 | 108..184 | CDD:240767 | 47/75 (63%) |
| RRM2_TDP43 | 193..262 | CDD:240768 | 45/68 (66%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165160178 | |
| Domainoid | 1 | 1.000 | 89 | 1.000 | Domainoid score | I7862 |
| eggNOG | 1 | 0.900 | - | - | E1_28HBV | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 352 | 1.000 | Inparanoid score | I2270 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1962 |
| OMA | 1 | 1.010 | - | - | QHG48344 | |
| OrthoDB | 1 | 1.010 | - | - | D390211at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0005498 | |
| OrthoInspector | 1 | 1.000 | - | - | otm40817 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_105367 | |
| Panther | 1 | 1.100 | - | - | O | PTHR48033 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X3916 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.720 | |||||