Protein Alignment TARDBP and tardbp

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: XP_012821726.1
• Gene: tardbp / 394651
• XenbaseID: XB-GENE-974453
• Length: 418
• Species: Xenopus tropicalis
• Alignment Length: 415
• Identity: 356/415 - (85%)
• Similarity: 379/415 - (91%)
• Gaps: 12/415 - (2%)

Human     3 EYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAG 67
            |||||.||||:||:|||||||||||||||||||||||||||||||:||||||||||||||||:.|
 Frog    13 EYIRVAEDENEEPMEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVNQCMRGVRLVEGILHAPENG 77

Human    68 WGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLM 132
            ||||||||||||||||||||||||||||:||||.||||||||||||||||||||:||||||||:|
 Frog    78 WGNLVYVVNYPKDNKRKMDETDASSAVKIKRAVTKTSDLIVLGLPWKTTEQDLKDYFSTFGEVIM 142

Human   133 VQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGR 197
            ||||||.|||||||||||||.:||||||||||||||||||||||||||| |.|||:|||||||||
 Frog   143 VQVKKDAKTGHSKGFGFVRFADYETQVKVMSQRHMIDGRWCDCKLPNSK-SPDEPMRSRKVFVGR 206

Human   198 CTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEP 262
            |||||:.:|||:||||||:|:||||||||||||||||||||:|||||||||||||:|||:|.|||
 Frog   207 CTEDMSAEELRQFFSQYGEVVDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGVSVHVSTAEP 271

Human   263 KHNSNRQLERSGRFGGNPG-GFGNQGGFGNSRGGGAGLGNNQGSNM--GGGMNFGAFSINPAMMA 324
            |||:||||||.|||   || .|||| |:.|||.....||||||.||  |||||||||||||||||
 Frog   272 KHNNNRQLERGGRF---PGPSFGNQ-GYPNSRPSSGALGNNQGGNMGGGGGMNFGAFSINPAMMA 332

Human   325 AAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSAS 389
            |||||||||||||||||||||||||.|:||.|||.||:..|:||| |||| ||||| |||||| .
 Frog   333 AAQAALQSSWGMMGMLASQQNQSGPQGSNQGQGNQQRDQPQSFGS-NNSY-GSNSG-AIGWGS-P 393

Human   390 NAGSGSGFNGGFGSSMDSKSSGWGM 414
            ||||||||||||.|||:||||||||
 Frog   394 NAGSGSGFNGGFSSSMESKSSGWGM 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	66/72 (92%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		14/15 (93%)
		RRM1_TDP43	105..178	CDD:409760	67/72 (93%)
		RRM2_TDP43	191..261	CDD:409761	59/69 (86%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414		161/200 (81%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250		9/10 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303		27/42 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373		22/31 (71%)
tardbp	XP_012821726.1	TDP43_N	14..87	CDD:465833	66/72 (92%)
		RRM1_TDP43	115..188	CDD:409760	67/72 (93%)
		RRM2_TDP43	200..270	CDD:409761	59/69 (86%)