Protein Alignment TARDBP and tardbpa

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: XP_073794270.1
• Gene: tardbpa / 386630
• ZFINID: ZDB-GENE-031030-1
• Length: 401
• Species: Danio rerio
• Alignment Length: 420
• Identity: 305/420 - (72%)
• Similarity: 353/420 - (84%)
• Gaps: 25/420 - (5%)

Human     1 MSE-YIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP 64
            |:| ||||.||||:||:|||||:|||||||||.||||||||||||:||||||||||||||:||||
Zfish     1 MTECYIRVAEDENEEPMEIPSEEDGTVLLSTVAAQFPGACGLRYRSPVSQCMRGVRLVEGVLHAP 65

Human    65 DAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGE 129
            :|.||||||||||||||||||||.||:||||:||.:|||||||||||||||||||||:||.||||
Zfish    66 EADWGNLVYVVNYPKDNKRKMDEMDAASAVKIKRGIQKTSDLIVLGLPWKTTEQDLKDYFGTFGE 130

Human   130 VLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK-----QSQDEPLR 189
            |:|||||:|.|:|:||||||||||:||||:||||||||||||||||||||||     ...|||:|
Zfish   131 VIMVQVKRDAKSGNSKGFGFVRFTDYETQIKVMSQRHMIDGRWCDCKLPNSKYFLEQAGPDEPMR 195

Human   190 SRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGIS 254
            ||||||||||||||.||||:||.|||:|.||||||||||||||||||||:|||||||||||||.|
Zfish   196 SRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGTS 260

Human   255 VHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSIN 319
            |||||||||||::||:...|||    ||:|.| |||:||        :..||    :||||.::|
Zfish   261 VHISNAEPKHNNSRQMMDRGRF----GGYGGQ-GFGSSR--------SPNSN----VNFGALNLN 308

Human   320 PAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIG 384
            ||||||||||||||||||||||:||||:..||.|.:..:..|:..|.:.:.:|:|: :.|.||:|
Zfish   309 PAMMAAAQAALQSSWGMMGMLANQQNQTPASGTNPSGQSGSRDQTQNYSASSNNYN-AGSSAALG 372

Human   385 WGSASNAGSGSGFNGGFGSSMDSKSSGWGM 414
            ||:.:|:.:..|||..|||||::||| |||
Zfish   373 WGAGTNSAAAGGFNSSFGSSMETKSS-WGM 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	63/72 (88%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		12/15 (80%)
		RRM1_TDP43	105..178	CDD:409760	63/72 (88%)
		RRM2_TDP43	191..261	CDD:409761	62/69 (90%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414		119/197 (60%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250		9/10 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303		19/41 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373		10/31 (32%)
tardbpa	XP_073794270.1	None