Protein Alignment TARDBP and TBPH

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 215/535 - (40%)
• Similarity: 283/535 - (52%)
• Gaps: 157/535 - (29%)

Human     3 EYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP--D 65
            ::::|:|:|.|||||:|:|:|||:||||:.|||||:|||:|||..::.:||||..||.|..|  :
  Fly     2 DFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVE 66

Human    66 AGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQ--KTSDLIVLGLPWKTTEQDLKEYFSTFG 128
            :|||...|...:||:||||.|:...:|..|.||...  :.:|||||||||||||:.|:|||.|:|
  Fly    67 SGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYG 131

Human   129 EVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK-QSQDEPLRSRK 192
            ||||.|:|||.|:|.|||||||||..|:.|::|::.||:||||||:.|:|||| .....|.   |
  Fly   132 EVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPC---K 193

Human   193 VFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHI 257
            |||||||||:..|:|||:||::|:|.|||||:|||||:||||.|..:||||||||.||||:|||:
  Fly   194 VFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHV 258

Human   258 SNAEPK--HNSNRQLE-------------------------RSG--------------------- 274
            |||.||  .|.|:|::                         |:|
  Fly   259 SNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNN 323

Human   275 -------------RFGGNP-GGFGNQGGFGNSRG-----------------------------GG 296
                         .:|||. ||:.|.||..:|.|                             ||
  Fly   324 HNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGG 388

Human   297 A---------------GLG--------NNQGSNMGGG--MNFGAFSINPAMMAAAQAALQSSWGM 336
            :               .||        :|||.||...  :|..:..||||::|||    .:.|.:
  Fly   389 SNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAA----LNQWSL 449

Human   337 MGMLASQQNQSGPSGN-----NQNQGNMQREPNQA--FGSGNNSYSGSNSGAA------------ 382
            :|.....|||....||     .||.|:     |.|  ||......:.:|:.||
  Fly   450 VGNQLQNQNQDQQGGNFLSWMAQNGGH-----NNANNFGGRKGPNNPNNNPAANGIKTDNSEPQN 509

Human   383 --IGWGSASNAGSGS 395
              .||   ||..|||
  Fly   510 GNTGW---SNQSSGS 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	40/74 (54%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		6/15 (40%)
		RRM1_TDP43	105..178	CDD:409760	50/72 (69%)
		RRM2_TDP43	191..261	CDD:409761	50/69 (72%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414		92/317 (29%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303		21/155 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373		12/38 (32%)
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	40/74 (54%)
		RRM1_TDP43	108..181	CDD:409760	50/72 (69%)
		RRM2_TDP43	192..261	CDD:409761	49/71 (69%)