DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and Hrb27C

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_476869.1 Gene:Hrb27C / 33968 FlyBaseID:FBgn0004838 Length:421 Species:Drosophila melanogaster


Alignment Length:351 Identity:108/351 - (30%)
Similarity:159/351 - (45%) Gaps:61/351 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   106 LIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQR--HMI 168
            |.|.||.|:||:::|..||..||:::...|.|:.::|.|:|||||.|.: .|.|..:.|.  |.:
  Fly     9 LFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFAD-PTNVNHVLQNGPHTL 72

Human   169 DGRWCDCKLPNSKQSQDEPLR--SRKVFVGRCTEDMTEDELREFFSQYGDVMDVFI-----PKPF 226
            |||..|.| |.:.::..:|.:  ..|||:|....::||.:||.||::||.|.:|.|     .|..
  Fly    73 DGRTIDPK-PCNPRTLQKPKKGGGYKVFLGGLPSNVTETDLRTFFNRYGKVTEVVIMYDQEKKKS 136

Human   227 RAFAFVTFADDQIAQSLCGEDLI-IKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFG 290
            |.|.|::|.::...:.:..|..| :.|..|.|..|||:..|..|...:...||..|..||:....
  Fly   137 RGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNSTVGGAYGKLGNECSHW 201

Human   291 NSRGGGAGLGNNQGSNMGG---GMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQ-----S 347
            ........:...|...|||   .|..||    |.||...|     .||    .:.||.|     |
  Fly   202 GPHHAPINMMQGQNGQMGGPPLNMPIGA----PNMMPGYQ-----GWG----TSPQQQQYGYGNS 253

Human   348 GPSGNNQNQG---NMQREP-----------NQAFGSGNNSYSGSNSGAAIG---------WGSAS 389
            || |:.|..|   ..|..|           .|.:| |.:.|:.:::||..|         |....
  Fly   254 GP-GSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYG-GYDMYNSTSTGAPSGPSGGGSWNSWNMPP 316

Human   390 NAGSGSGFNG-GFGSSMD--SKSSGW 412
            |:...:|..| |.|::.|  |::..|
  Fly   317 NSAGPTGAPGAGAGTATDMYSRAQAW 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98
RRM1_TDP43 105..178 CDD:409760 31/73 (42%)
RRM2_TDP43 191..261 CDD:409761 25/75 (33%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 63/237 (27%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 9/41 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 14/50 (28%)
Hrb27CNP_476869.1 RRM1_hnRNPA_hnRNPD_like 9..80 CDD:409763 30/71 (42%)
RRM2_DAZAP1 94..173 CDD:409765 26/78 (33%)
Blue background indicates that the domain is not in the aligned region.

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