Protein Alignment TARDBP and SPOM_SPAC25G10.01

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_001342863.1
• Gene: SPOM_SPAC25G10.01 / 3361412
• PomBaseID: SPAC25G10.01
• Length: 297
• Species: Schizosaccharomyces pombe
• Alignment Length: 162
• Identity: 41/162 - (25%)
• Similarity: 73/162 - (45%)
• Gaps: 34/162 - (20%)

Human    12 NDEPIEIPSED-DGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVV 75
            ::|..|||:.| .|:.:|.|.|:|           .:.|..     :|......|:..|::...|
pombe     9 SEESFEIPNADVAGSAVLETETSQ-----------DIHQLE-----IEKDAGETDSDAGSIAMNV 57

Human    76 N--------YPKDNKRKMDETDASSAVKVKRAVQKT--------SDLIVLGLPWKTTEQDLKEYF 124
            :        ....|:.::|..:.|:|:. |:..|..        :||.|.|:..:..|.:|::.|
pombe    58 HQLDTAGEPLQSMNEDEVDPNNESTALD-KKEPQSAPEGSENLGNDLFVSGIASRMQEDELQQIF 121

Human   125 STFGEVLMVQVKKDLKTGHSKGFGFVRFTEYE 156
            |.||.|..|::.::..|..|:||||:.|:..|
pombe   122 SKFGTVTHVRIMREPVTKASRGFGFLSFSTVE 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	15/73 (21%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		3/15 (20%)
		RRM1_TDP43	105..178	CDD:409760	20/52 (38%)
		RRM2_TDP43	191..261	CDD:409761
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373
SPOM_SPAC25G10.01	NP_001342863.1	PABP-1234	56..>201	CDD:130689	27/99 (27%)
		RRM	103..174	CDD:214636	19/51 (37%)
		U2AF_lg	207..>283	CDD:273727