DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TARDBP and tardbpb

DIOPT Version :9

Sequence 1:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_958884.1	Gene:	tardbpb / 325052	ZFINID:	ZDB-GENE-030131-3777	Length:	412	Species:	Danio rerio

Alignment Length:	422	Identity:	313/422 - (74%)
Similarity:	358/422 - (84%)	Gaps:	18/422 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSE-YIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP 64
            |:| ||||.|:||:||:|||||||||||||||:||||||||||:|:||||||||||||:||||||
Zfish     1 MAEMYIRVAEEENEEPMEIPSEDDGTVLLSTVSAQFPGACGLRFRSPVSQCMRGVRLVDGILHAP 65

Human    65 DAGWGNLVYVVNYPK-----DNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYF 124
            :.|||||||||||||     ||||||||.|||||.|:||..|||||||||||||||:|||||:||
Zfish    66 ENGWGNLVYVVNYPKETVLPDNKRKMDEIDASSATKIKRGDQKTSDLIVLGLPWKTSEQDLKDYF 130

Human   125 STFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLR 189
            .|||||:|||||:|:|||:|||||||||.::|||.|||:|||||||||||||||||||..|||:|
Zfish   131 GTFGEVIMVQVKRDVKTGNSKGFGFVRFGDWETQSKVMTQRHMIDGRWCDCKLPNSKQGIDEPMR 195

Human   190 SRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGIS 254
            ||||||||||||||.||||:||.|||:|.||||||||||||||||||||:|.:||||||||||:|
Zfish   196 SRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAAALCGEDLIIKGVS 260

Human   255 VHISNAEPKHNSNRQ-LERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSI 318
            |||||||||||:.|| :||:||||   .|||.| ||..||....|.|....|::|   |||.|::
Zfish   261 VHISNAEPKHNNTRQMMERAGRFG---NGFGGQ-GFAGSRSNMGGGGGGSSSSLG---NFGNFNL 318

Human   319 NPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAI 383
            ||||||||||||||||||||||| ||||||.||.:.:..:..|:..|.:.|.|::| ||:| ||:
Zfish   319 NPAMMAAAQAALQSSWGMMGMLA-QQNQSGTSGTSTSGTSSSRDQAQTYSSANSNY-GSSS-AAL 380

Human   384 GWGSASNAGSGS-GFNGGFGSSMDSKSSGWGM 414
            |||:.||:|:.| |||..|||||:||||||||
Zfish   381 GWGTGSNSGAASAGFNSSFGSSMESKSSGWGM 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118	62/72 (86%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		12/15 (80%)
		RRM1_TDP43	105..181	CDD:240767	63/75 (84%)
		RRM2_TDP43	191..261	CDD:240768	60/69 (87%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		130/199 (65%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		7/10 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		23/42 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373		13/31 (42%)
tardbpb	NP_958884.1	RRM	<85..>177	CDD:223796	73/91 (80%)
		RRM1_TDP43	111..187	CDD:240767	63/75 (84%)
		RRM2_TDP43	197..267	CDD:240768	60/69 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343775
Domainoid	1	1.000	198	1.000	Domainoid score	I12993
eggNOG	1	0.900	-	-		E1_28HBV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7221
Inparanoid	1	1.050	609	1.000	Inparanoid score	I5149
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48344
OrthoDB	1	1.010	-	-		D1425837at2759
OrthoFinder	1	1.000	-	-		FOG0005498
OrthoInspector	1	1.000	-	-		otm26684
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3916
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	16	16.370