DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and rna15

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_593884.1 Gene:rna15 / 2543462 PomBaseID:SPAC644.16 Length:422 Species:Schizosaccharomyces pombe


Alignment Length:319 Identity:62/319 - (19%)
Similarity:117/319 - (36%) Gaps:88/319 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   104 SDLIVLG-LPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHM 167
            |.::.:| :|::..|:.:.:.|...|.|...|:..|.::|..||:||..:.:..|....:...:.
pombe     4 SCVVYVGNIPYEMAEEQVIDIFKQSGPVKSFQLVIDPESGQPKGYGFCEYHDPATAASAVRNLNN 68

Human   168 IDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFF-----SQYGDVMDVFIPKPFR 227
            .|.                  .:|::.|    :..|.|::|...     |:||     :.|:.:.
pombe    69 YDA------------------GTRRLRV----DFPTADQIRRLDKLLGPSRYG-----YYPQSYA 106

Human   228 AFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNS 292
            ..:: |:.:                   :..:..|...|.:.|.:|..:...|.. |.:|  |::
pombe   107 NQSY-TYGN-------------------NFGSYPPTQPSTQPLPQSYGYPSYPPA-GYRG--GSA 148

Human   293 RGGG-----------AGLGNNQGSNMGGGMN----------FGAFSINPAM-MAAAQAALQSSWG 335
            |..|           |.|..|:...|...:.          ...|..||.: .|..||.|...:.
pombe   149 RPSGVLANDEVYRVLAQLAPNEIDYMLSAIKALCLEAPEQAAQLFETNPQLSYAVFQAMLMKRYT 213

Human   336 MMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYS----GSNSGAAIGWGSASN 390
            ...::|   :...|:|.|....   :|||:.:.|..::||    |..|..:..:|.||:
pombe   214 SESVVA---DLLIPAGVNLPGA---QEPNRGYFSPMHTYSSAVPGPISVPSAPYGRASS 266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98
RRM1_TDP43 105..178 CDD:409760 15/73 (21%)
RRM2_TDP43 191..261 CDD:409761 10/74 (14%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 38/201 (19%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 0/10 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 12/52 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373 8/31 (26%)
rna15NP_593884.1 RRM_CSTF2_RNA15_like 5..80 CDD:409832 17/96 (18%)
CSTF2_hinge 150..222 CDD:433869 13/74 (18%)
Blue background indicates that the domain is not in the aligned region.

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