Protein Alignment TARDBP and rnp24

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_594970.1
• Gene: rnp24 / 2542965
• PomBaseID: SPAC3G6.04
• Length: 369
• Species: Schizosaccharomyces pombe
• Alignment Length: 228
• Identity: 52/228 - (22%)
• Similarity: 91/228 - (39%)
• Gaps: 56/228 - (24%)

Human     2 SEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDA 66
            ||.|:...:||.:||.       |..::.:  ..|.:...|::|      :|...|:  ....||
pombe   130 SEMIKEVSEENIKPIT-------TEQITRI--HMPMSKEKRFQN------KGFAYVD--FATEDA 177

Human    67 ------------GWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLG-LPWKTTEQ 118
                        ...|::...|.....:........|....::.:.::.|.::.:| |.::||:.
pombe   178 LKLALQCSEKALNGRNILIKSNTDFSGRPSKPANTLSKTASIQSSKKEPSSILFVGNLDFETTDA 242

Human   119 DLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRH----------------- 166
            ||||:|...|::..|::.....||..||||||.|.:.:|.:|.|...|
pombe   243 DLKEHFGQVGQIRRVRLMTFEDTGKCKGFGFVDFPDIDTCMKAMELGHNSWRLEYGEDRSKRMRN 307

Human   167 ----MIDGRWCDCKLPNSKQSQDEP--LRSRKV 193
                ...||:.|.:   |...:|:|  .|:||:
pombe   308 KSPMARSGRFNDAE---SLGQEDKPNFKRARKI 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	14/84 (17%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		1/15 (7%)
		RRM1_TDP43	105..178	CDD:409760	27/94 (29%)
		RRM2_TDP43	191..261	CDD:409761	2/3 (67%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373
rnp24	NP_594970.1	RRM1_Nop13p_fungi	107..199	CDD:409830	16/85 (19%)
		RRM2_Nop13p_fungi	230..299	CDD:409831	24/68 (35%)