DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and gar2

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_593531.1 Gene:gar2 / 2542869 PomBaseID:SPAC140.02 Length:500 Species:Schizosaccharomyces pombe


Alignment Length:256 Identity:76/256 - (29%)
Similarity:116/256 - (45%) Gaps:33/256 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    80 DNKRKMDETDASSAVKVKRAVQ---KTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKT 141
            :.|||.:........|:.:..|   :|..:.|..|.|...:|.|.:.|..:|.::..:|..|.::
pombe   236 EKKRKAEPASEERPAKITKPSQDSNETCTVFVGRLSWNVDDQWLGQEFEEYGTIVGARVIMDGQS 300

Human   142 GHSKGFGFVRFTEYETQVKVMSQR--HMIDGRWCDCKLPNSKQSQDEPLRSRK------------ 192
            |.|||:|:|.|...|.....::..  ..||||..:..|.|.:.:..:|...::            
pombe   301 GRSKGYGYVDFETPEAAKAAVAANGTKEIDGRMVNLDLSNPRPANPQPYAQQRAGNFGDQLSEPS 365

Human   193 --VFVGRCTEDMTEDELREFFSQYGDVMDVFIPKP-----FRAFAFVTFADDQIAQSLCGE--DL 248
              ||||..:.:.|||:|...|...||:..:.:|..     .:.|.:|||:|...|:. |.|  ..
pombe   366 DTVFVGNLSFNATEDDLSTAFGGCGDIQSIRLPTDPQSGRLKGFGYVTFSDIDSAKK-CVEMNGH 429

Human   249 IIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRG---GGAGLGN-NQGS 305
            .|.|....:..:.|:.....:..|.| |||. ||||.:||||..||   |||..|| |:||
pombe   430 FIAGRPCRLDFSTPRTGGGSRGGRGG-FGGR-GGFGGRGGFGGGRGRGRGGARSGNPNRGS 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98 4/15 (27%)
RRM1_TDP43 105..178 CDD:409760 21/74 (28%)
RRM2_TDP43 191..261 CDD:409761 22/90 (24%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 36/101 (36%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 21/45 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373
gar2NP_593531.1 PRK13808 <2..64 CDD:172341
RRM_SF 264..339 CDD:473069 21/74 (28%)
RRM2_gar2 368..439 CDD:409882 22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

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