DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TARDBP and SPAC328.05

DIOPT Version :9

Sequence 1:	NP_031401.1	Gene:	TARDBP / 23435	HGNCID:	11571	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_594207.3	Gene:	SPAC328.05 / 2542567	PomBaseID:	SPAC328.05	Length:	464	Species:	Schizosaccharomyces pombe

Alignment Length:	259	Identity:	51/259 - (19%)
Similarity:	88/259 - (33%)	Gaps:	70/259 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    69 GNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMV 133
            |.|||:....:.|.|....:.:.||....:..:....|.|..||:....||||:.|...|.|:..
pombe   144 GRLVYIREDREQNARFGSSSVSPSASSNGKDSEPDRQLFVGNLPYNVRWQDLKDLFRQAGSVIRA 208

Human   134 QVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMID--GRWCDCKLPNSKQSQDEPLR------- 189
            .::.: :.|.|:|.|.|..:..:..:..:...|..|  ||..:.:|......:.:|..
pombe   209 DIQMN-QEGRSRGIGIVVMSSMKEAMHAIQMLHNTDFMGRTLEVRLDRFAHHKSKPYSTHGNGYT 272

Human   190 ------------------------------------SRKVFVGRCTEDMTEDELREFFSQYGDVM 218
                                                |..::||......::..|.:.|:..|.|:
pombe   273 FPAEMQMTTSSTYLPMLGANTQVEDLVYHAYPHGPCSDCIYVGNLPWATSDRNLLDLFTDIGSVI 337

Human   219 DVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSG--RFGGNP 280
                    ||         :||....|..   ||..|  ...|.::::...:|:..  |:||.|
pombe   338 --------RA---------RIAYEPTGRS---KGFGV--VQFENENDAASSIEKLNGYRYGGRP 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:376118	4/7 (57%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:18957508	82..98		3/15 (20%)
		RRM1_TDP43	105..181	CDD:240767	21/77 (27%)
		RRM2_TDP43	191..261	CDD:240768	14/69 (20%)
		Interaction with UBQLN2. /evidence=ECO:0000269\|PubMed:23541532	216..414		15/67 (22%)
		Nuclear export signal. /evidence=ECO:0000269\|PubMed:18957508	239..250		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..303		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..373
SPAC328.05	NP_594207.3	RRM	71..387	CDD:223796	51/259 (20%)
		RRM_SF	79..150	CDD:240668	4/5 (80%)
		RRM3_hnRNPM_like	181..252	CDD:240833	20/71 (28%)
		RRM_SF	312..385	CDD:302621	20/90 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910