DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and usp101

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_593779.1 Gene:usp101 / 2542461 PomBaseID:SPAC19A8.13 Length:261 Species:Schizosaccharomyces pombe


Alignment Length:317 Identity:68/317 - (21%)
Similarity:113/317 - (35%) Gaps:112/317 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    15 PIEIPSEDDGTVLLSTVT--AQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNY 77
            |:::|.|...|..:|.:.  .::..:...:|....|...:.:||                     
pombe    24 PMDVPPEKRSTPRVSGIAKYLKYAQSHDQQYHPTESLEEKRLRL--------------------- 67

Human    78 PKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWK----------TTEQDLKEYFSTFGEVLM 132
             :|.|:|.......|.:||   .....|..|:|.|:|          |.|.|::..|:.:|.:..
pombe    68 -RDEKQKQQRERLRSMIKV---WDPDHDRHVIGDPYKTMFLSRLSYDTKESDIEREFTRYGPIER 128

Human   133 VQVKKDLKTGHSKGFGFVRFTEYETQVKV---MSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVF 194
            ::|.::..||.|.|:.||.| |.|..:||   .|...|::||                       
pombe   129 IRVVRNKVTGKSMGYAFVVF-ERERDLKVAYKASAGLMLNGR----------------------- 169

Human   195 VGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISN 259
              |...|:          :.|..:..::|:             ::...|.|.         |.:.
pombe   170 --RIVVDV----------ERGRTVKGWLPR-------------KLGGGLGGR---------HYTK 200

Human   260 AEPKHNSNRQLERSGRFGGNPGGF--GNQGGFGNSRGGGAGLG-----NNQGSNMGG 309
            ..|:.      ||..||.|: .||  |.:|||..|.|||:..|     ::..|:.||
pombe   201 ERPRR------ERGSRFRGD-SGFRGGYRGGFRKSSGGGSRFGRGPTRSSHSSDYGG 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833 9/63 (14%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98 5/15 (33%)
RRM1_TDP43 105..178 CDD:409760 26/85 (31%)
RRM2_TDP43 191..261 CDD:409761 7/69 (10%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 24/101 (24%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 2/10 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 17/48 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373
usp101NP_593779.1 U1snRNP70_N 3..91 CDD:432406 15/91 (16%)
RRM_snRNP70 99..188 CDD:409682 26/137 (19%)
Blue background indicates that the domain is not in the aligned region.

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