DRSC/TRiP Functional Genomics Resources

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Protein Alignment TARDBP and usp109

DIOPT Version :10

Sequence 1:NP_031401.1 Gene:TARDBP / 23435 HGNCID:11571 Length:414 Species:Homo sapiens
Sequence 2:NP_596836.2 Gene:usp109 / 2540117 PomBaseID:SPBC1289.12 Length:365 Species:Schizosaccharomyces pombe


Alignment Length:280 Identity:57/280 - (20%)
Similarity:97/280 - (34%) Gaps:57/280 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     3 EYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDA- 66
            :|||.. .||...:....:.:...:|.|...:|......  ||.:.: ....||:.|...:.|. 
pombe    17 DYIRAI-FENVRKVNYYEDGESGAILKTCCIEFESQDAA--RNALER-QSTQRLISGNPISLDVV 77

Human    67 -GWGNLVYVVNYPKDNKRKMDETDAS--------SAVKVKRAVQKTSDLIVLGLPWKTTEQDLKE 122
             .|....|.:.:..:...::.|.|..        .:.:|.|.|..||..|  ...|...|.|::.
pombe    78 PEWQKPSYYMLFISNIDPEVSENDIKYLFQRYNFISARVLRCVDGTSTSI--AFIWLANESDIQN 140

Human   123 -------YFSTFGEVLMVQVKKDLKTG-HSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPN 179
                   .|.....:|:..||.|..|. .|.||       |.|                    |.
pombe   141 AQVEMQGAFCLKRSILVHSVKSDKNTYLSSPGF-------YGT--------------------PQ 178

Human   180 SKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVT--FADDQIAQS 242
            ......:| .:..|:|.:..|::|..|||.:|..:|:::...:........|..  ||:..|.:.
pombe   179 PLNQFTDP-NNTAVYVHQLPENITTQELRSYFLHFGEILYTQVNNNSGRIVFAQRYFAEQAINEM 242

Human   243 LCGEDLIIKGISVHISNAEP 262
               .:..:.|:.:.:|.|.|
pombe   243 ---NNFPLHGVRIQLSWARP 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TARDBPNP_031401.1 TDP43_N 4..77 CDD:465833 16/74 (22%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 82..98 3/23 (13%)
RRM1_TDP43 105..178 CDD:409760 15/80 (19%)
RRM2_TDP43 191..261 CDD:409761 15/71 (21%)
Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 216..414 8/49 (16%)
Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 239..250 1/10 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..303 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..373
usp109NP_596836.2 PABP-1234 4..>243 CDD:130689 53/262 (20%)
RRM_SF 188..256 CDD:473069 14/70 (20%)
Blue background indicates that the domain is not in the aligned region.

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