Protein Alignment TARDBP and Tardbp

DIOPT Version :10

• Sequence 1: NP_031401.1
• Gene: TARDBP / 23435
• HGNCID: 11571
• Length: 414
• Species: Homo sapiens
• Sequence 2: NP_663531.1
• Gene: Tardbp / 230908
• MGIID: 2387629
• Length: 414
• Species: Mus musculus
• Alignment Length: 414
• Identity: 398/414 - (96%)
• Similarity: 409/414 - (98%)
• Gaps: 0/414 - (0%)

Human     1 MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPD 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPD 65

Human    66 AGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEV 130
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||
Mouse    66 AGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEV 130

Human   131 LMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||
Mouse   131 LMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFV 195

Human   196 GRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNA 260
            ||||||||.:||::||.|||:|:|||||||||||||||||||::|||||||||||||||||||||
Mouse   196 GRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNA 260

Human   261 EPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAA 325
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
Mouse   261 EPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAA 325

Human   326 AQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASN 390
            |||||||||||||||||||||||||||||:||:|||||||||||||||||||||||.:|||||||
Mouse   326 AQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASN 390

Human   391 AGSGSGFNGGFGSSMDSKSSGWGM 414
            ||||||||||||||||||||||||
Mouse   391 AGSGSGFNGGFGSSMDSKSSGWGM 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TARDBP	NP_031401.1	TDP43_N	4..77	CDD:465833	72/72 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508	82..98		15/15 (100%)
		RRM1_TDP43	105..178	CDD:409760	71/72 (99%)
		RRM2_TDP43	191..261	CDD:409761	60/69 (87%)
		Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532	216..414		188/197 (95%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508	239..250		9/10 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..303		41/41 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..373		29/31 (94%)
Tardbp	NP_663531.1	TDP43_N	4..77	CDD:465833	72/72 (100%)
		RRM1_TDP43	105..178	CDD:409760	71/72 (99%)
		RRM2_TDP43	191..261	CDD:409761	60/69 (87%)
		Interaction with UBQLN2. /evidence=ECO:0000250|UniProtKB:Q13148	216..414		188/197 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..301		39/39 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..414		68/72 (94%)