Protein Alignment AP4E1 and g

DIOPT Version :10

• Sequence 1: NP_031373.2
• Gene: AP4E1 / 23431
• HGNCID: 573
• Length: 1137
• Species: Homo sapiens
• Sequence 2: NP_524785.2
• Gene: g / 44819
• FlyBaseID: FBgn0001087
• Length: 1034
• Species: Drosophila melanogaster
• Alignment Length: 938
• Identity: 215/938 - (22%)
• Similarity: 373/938 - (39%)
• Gaps: 178/938 - (18%)

Human    32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASF 96
            |...|..|||||.  .:|..|.|.|...:..:|..:.....::|.  ..:.:|.|.:|||||.|:
  Fly    15 FDKNLTDLVRGIR--NNKDNEAKYISTCIEEIKQELRQDNISVKC--NAVAKLTYIQMLGYDISW 75

Human    97 GYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIF 161
            ...:.|::........||:||||.|...|...|||:|..|.:.|||.|.|..:..:||:.:|...
  Fly    76 AGFNIIEVMSSSRFTCKRIGYLAASQCFHPDSELLMLTTNMIRKDLNSQNQYDAGVALSGLSCFI 140

Human   162 PCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASL 226
            ..::...:...|...:..:|..:|.||||.:||..|..|..::....|.::.|.|.|.||.:|::
  Fly   141 SPDLSRDLANDIMTLMSSTKPYLRMKAVLMMYKVFLRYPEALRPAFPKLKEKLEDPDPGVQSAAV 205

Human   227 HIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRT 291
            ::...:.::|...|..|...|..::......              |:.|:::::.|.|...:.|.
  Fly   206 NVICELARKNPKNYLPLAPIFFKLMTTSTNN--------------WMLIKIIKLFGALTPLEPRL 256

Human   292 SELMYDVLDESLRRAELNHNVT-YAILFECVHTVYS--IYPKSELLEKAAK---CIGK---FVLS 347
            .:.:.:.|      ..|.|:.: .::|:||::||.:  |...|.:...:|.   |:.|   .:..
  Fly   257 GKKLIEPL------TNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSASIQLCVQKLRILIED 315

Human   348 PKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQK 412
            ...|||||||.|::.:::..|.....|:..|:.|||..|..|:...|:|||.:.:.:|:..||::
  Fly   316 SDQNLKYLGLLAMSKILKTHPKSVQAHKDLILACLDDKDESIRLRALDLLYGMVSKKNLMEIVKR 380

Human   413 MLEYLHQSKEEYVIVNLVGKIAELAEK----YAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRL 473
            :|.::.:::.......|:.|:.|:..:    |..:..|::..:..:..:.....|.       ||
  Fly   381 LLGHMERAEGSAYRDELLYKVIEICAQSSYLYVTNFEWYLTVLVELIQLEAGSRHG-------RL 438

Human   474 LAEG-FDDETEDQQLRLYAVQSYLTLLD------MENVFYPQRFLQVMSWVLGEYS-YLLDKETP 530
            :||. .|.......:|.:||.....|||      ..|..|  ..|...:|::||:: .|.|.|..
  Fly   439 IAEQLLDVAIRVPVVRQFAVNEMTNLLDTFTVSAQSNSMY--EVLYAAAWIVGEFAGELEDAEKT 501

Human   531 EEVIAKLYKL---LMNDSVSSETKAWLIAAVTKLTSQ------AHSSNTVERLIHEFTISLDTCM 586
            ..::.:...|   :....|.:..|.:...|.|.|..|      ....:.:::|.| |..|.|..:
  Fly   502 LNILLRPRLLPGHIQGVYVQNVIKLFARLATTCLELQDLPGLVTLCDHVLDKLQH-FNGSSDIEV 565

Human   587 RQHA----FELKHLHENVELMKSLLPVDRSCE--------DLVVDASLSFLDGFVAEGLSQGAAP 639
            ::.|    ..::.|...:......:.:|.:.|        ::|.:.:|.|....:         |
  Fly   566 QERANSACMLIEMLRNQLSTSTDAMAMDTTTEGGIPPLAIEIVQEMTLLFTGELI---------P 621

Human   640 YKPPHQRQ---EEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSL 701
            ..|..||:   .:.|..::.:|..|...:.|||  :.......:.:.:..:|..|:.|.|...||
  Fly   622 VAPKAQRKVPLPDGLDLDEWINAPPPEDAASSS--SSEHDKDELFVSATQAGTGADGGEKRRQSL 684

Human   702 KL-------EGIKKLWGKEG---YLPKKESKTG-------DESGALPVPQESI-MENVDQ---AI 745
            :|       :.:.:|..:..   ||....:.:|       |....:|:.:..: ||.|..   .|
  Fly   685 ELTPEQLERQRMARLIEQSNNPHYLKSTPTASGASNADQYDNIDDIPITELPLDMEGVAALRVGI 749

Human   746 TKK-----DQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAK-- 803
            ||:     .:.|....||:.|:|                           ||..:|||..:.|
  Fly   750 TKRSDKYLQEQQAAQGSKDGKKK---------------------------HKKGKKSKKAKNKVA 787

Human   804 -------SGETTSTH--NMTCSSFSSLSNVAYED---DYYSNTLHDTGDKELKKFSLTSELLDSE 856
                   .||....|  |.|......:|....||   .|..|..|...|.||
  Fly   788 YNSSSESEGEPKPLHIVNTTLDMPEGVSMSDSEDKDGKYDPNDPHRALDIEL------------- 839

Human   857 SLTEL--PLVEKFSYCS------LSTPS 876
            .:||.  |.|...|..|      |.||:
  Fly   840 DITEFEAPAVRSASKKSAADKENLKTPA 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP4E1	NP_031373.2	Adaptin_N	52..596	CDD:396262	138/577 (24%)
		Interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808	727..1137		41/181 (23%)
		AP4E_app_platf	1033..1133	CDD:464326
g	NP_524785.2	Adaptin_N	33..578	CDD:396262	138/576 (24%)
		AP3D1	687..840	CDD:461889	37/192 (19%)