DRSC/TRiP Functional Genomics Resources

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Protein Alignment AP4E1 and CG33090

DIOPT Version :10

Sequence 1:NP_031373.2 Gene:AP4E1 / 23431 HGNCID:573 Length:1137 Species:Homo sapiens
Sequence 2:NP_788055.2 Gene:CG33090 / 34835 FlyBaseID:FBgn0028916 Length:948 Species:Drosophila melanogaster


Alignment Length:213 Identity:52/213 - (24%)
Similarity:74/213 - (34%) Gaps:57/213 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   826 YEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTEL---------PLVEKFSYCSLSTPSLFANN 881
            |.|.|..|.|.........||| :.|.:|.|||.||         ...||..  :..:.|::.|.
  Fly   613 YRDYYVLNELAQAQSDNASKFS-SIEFIDKESLYELYSQDNKRKNSADEKQQ--NRKSASMYINE 674

Human   882 N------MEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDD-- 938
            .      |:.....::..||       ..:.:|.|.||...|. .:..|..:...:|..|..|  
  Fly   675 TNGKVYLMDAIGYLKAMYAS-------CKAIMERTIEYDKDND-GLIENTKMPDQTYDSWVMDGP 731

Human   939 ---CLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPGCCLPVME-AESTKSFQYSVQIEKPFT 999
               |          |||.|  |.|:...| ...:.:||..||...: .|..|.     .:|:...
  Fly   732 SAYC----------SGLWL--AALQAMSA-MATILDQPNDCLRYQDILEKGKR-----SLEEKLW 778

Human  1000 EGNLTGFISYHMMD-THS 1016
            .|      ||:..| :||
  Fly   779 NG------SYYRFDLSHS 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AP4E1NP_031373.2 Adaptin_N 52..596 CDD:396262
Interaction with TEPSIN. /evidence=ECO:0000269|PubMed:26542808 727..1137 52/213 (24%)
AP4E_app_platf 1033..1133 CDD:464326
CG33090NP_788055.2 Glyco_hydr_116N 132..445 CDD:463496
DUF608 505..936 CDD:461391 52/213 (24%)
Blue background indicates that the domain is not in the aligned region.

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