DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC7A8 and CG1607

DIOPT Version :9

Sequence 1:	NP_036376.2	Gene:	SLC7A8 / 23428	HGNCID:	11066	Length:	535	Species:	Homo sapiens
Sequence 2:	NP_001263139.1	Gene:	CG1607 / 43707	FlyBaseID:	FBgn0039844	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	250/515 - (48%)
Similarity:	341/515 - (66%)	Gaps:	23/515 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     3 EGARHRNNTEKKHPGGGESDASPE--------AGSGGGGVALKKEIGLVSACGIIVGNIIGSGIF 59
            |....:|::.|.....|..|||.:        .|.|||.|.||.::.|::.|.:|||:|||||||
  Fly     4 ESLNRKNSSRKSSIVNGNGDASAKLTNGDGDGGGDGGGEVTLKAKMSLLNGCTVIVGSIIGSGIF 68

Human    60 VSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLW 124
            |||.|||...|||.||||||:::|..::|||.||||||..|.|||.||:|:.:.||....|:|||
  Fly    69 VSPTGVLMYTGSVNLALIVWVISGLFSMVGAYCYAELGTMITKSGADYAYIMETFGPFMAFIRLW 133

Human   125 IAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDI 189
            |..:::.|.:||::|||||.|||:|.||.|.|||...||||..|:|:||.:||..|:|||.||||
  Fly   134 IECMIVRPCSQAIVALTFSTYVLKPFFPECTPPEDSARLLAVCCILVLTLINCWDVKWATAVQDI 198

Human   190 FTAGKLLALALIIIMGIVQICKG--EYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLN 252
            ||..|||||.:||..|:.|:..|  :||      .||| .:..:..:||:|..|.|||.|||:||
  Fly   199 FTYAKLLALFIIIATGVYQLYLGNTQYF------TFEN-TDTKVTSIALSFYSGLFAYNGWNYLN 256

Human   253 YVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWI 317
            ::.|||.||.|||||||.||..|||.|||.|||::.|.:||.|::.|:|||||:.|:..|::||.
  Fly   257 FIIEELKDPVKNLPRAIAISCTLVTIVYVMANVSFYTILSPDEVMGSSAVAVTYAERAFGMLAWT 321

Human   318 MPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTS 382
            :|:.|||||||.|||.|.||||||:|||..|.:|.:|.||.::|.||.||:|...:.::|.|..|
  Fly   322 IPVFVALSTFGAVNGILLTSSRLFYAGANNGQMPEILTMIQIQRFTPTPAVLAMALLSMLYLTVS 386

Human   383 DMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPV 447
            |::.|||||||..:|..||.|.....|||.:|::||||::.::|||:||:...|:.|..:::.||
  Fly   387 DIFALINYVGFATWLSIGVAVLCLPWLRWAQPNLPRPIRVPMVFPIVYLIATIFVTVVPMYASPV 451

Human   448 VCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEA 507
            ..|.|:.::|:.:|||.:.:.|::||..|...:..||...|||.:|:      |..|:.|
  Fly   452 ETGYGILMILSSIPVYLVFIAWKNKPIWFQKTMVSLTRFLQKMLMVL------GKQTKPA 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC7A8	NP_036376.2	2A0308	1..497	CDD:273332	247/503 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..535		2/6 (33%)
CG1607	NP_001263139.1	2A0308	42..501	CDD:273332	237/471 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1417
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	1	1.100	-	-	LDO	PTHR11785
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.840