DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRIP1 and CG15803

DIOPT Version :9

Sequence 1:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens
Sequence 2:	NP_001287388.1	Gene:	CG15803 / 42206	FlyBaseID:	FBgn0038606	Length:	880	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	199/958 - (20%)
Similarity:	326/958 - (34%)	Gaps:	314/958 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   122 EFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 186
            |:....|::|: .:|..||..:.||  :.....:..|..||:|.|..:|.:||::..:..:||..
  Fly     6 EWSQVEVIDLI-NDGNGLGFILVGG--RSTGVVIKALTPGGVAERDGRLQLGDHLLQIGEVNLRG 67

Human   187 FRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTV----------------EVTLH---- 231
            |..:::.::|:..|.:|.|.|...:.|.::.     ::|:                |::.|
  Fly    68 FSSEQVATVLRQTGAQVRLIVARPVEPTAID-----YQTLACQAPIIPTKLLSDPEELSRHLFQN 127

Human   232 ---------------------KEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGT---- 271
                                 .:|:..|    ||..|..:     ::..|| ||||  |||
  Fly   128 PSFATAAVAAAAAAAAAAGSGSDGDVGG----GGVLDVAS-----LVGLVR-GGPA--EGTELSA 180

Human   272 IKP----------------GD-----------------------------RL-LSVDGIRLLGTT 290
            ::|                ||                             || |.:....:|...
  Fly   181 VEPQPSAAVLQLQQLSELAGDLADFPLPPIPGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPP 245

Human   291 HAEAMSILK-----QCGQEAALLIEYDV-------------------------SVMDSVATASGP 325
            ...|:.:|.     :|.|:....||..:                         |.|||..|.:
  Fly   246 PRPALQMLPLETQWRCVQDQNRHIETVIADSKRKLLANEDGGSASASGSGSPDSYMDSPETET-- 308

Human   326 LLVEVAKTPGASLGVALTTSMCCNKQV--IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCT 388
            .:||:.|.. ..||:.:...:|..:.:  |.:..|...|.|:..|.:.:.|.|:::||.|:...|
  Fly   309 YVVELHKNV-YGLGITVAGYVCEEEDLSGIFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVT 372

Human   389 LAEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQLTWDSWASNHSSLHTNHHYNTY 453
            ..:|.:.|.||      :|:.|......|:|..:..:|.:   ||.....|..|.|.     .:.
  Fly   373 NHQAVELLRNT------DIVVHLTLERFLRGRKYEHLQVA---LTEIKGTSAPSGLD-----RSQ 423

Human   454 HPDHCRVPALTFPKAP--------PPNSPPA--------------------------------LV 478
            ..|..:...|:.|.:|        ||.|..|                                .|
  Fly   424 DKDQDQESQLSMPGSPSIATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTV 488

Human   479 SSSFSPTSMSAYSLSSLNMGTLP-----------RSLYSTSPRG-------------TMMRRRLK 519
            .|:.|.....:.....|....:|           |||......|             |...|:..
  Fly   489 ESNMSHVLDRSDHSGGLTKDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGS 553

Human   520 KKDFKSSLSLASSTVGL-------AGQVVHTETTEV-VLTADPVT--------GFGIQLQGSVFA 568
            |.:.:....|..:....       .|| :.|.|.|. |..|.|..        ..||.|:|:|..
  Fly   554 KPETERVKDLGDTKTDTDPDPDLDPGQ-MPTPTNEAPVKAASPTAASLRVAWKSLGISLEGTVDV 617

Human   569 TETLSSPP--LISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 631
            ...:...|  .|..|.||.|..|.|:|:.||.::.:|         |...|.||...:. |:..|
  Fly   618 ECGIEKRPHHYIRSILADGPVGRQGILRPGDELLQVN---------EHKLQGLRHIEVV-KILKE 672

Human   632 IEFDV---------AESVIPSS---GTFHVK--LPKKHN--VELGITISSPSSRKPGDPLVISDI 680
            :...|         ..|||.:|   ..|..:  ||..|.  ..|.....|.||........::|
  Fly   673 LPARVKLVCARGTHVPSVINTSQNPEAFETRSLLPGGHQSLQNLLSKAQSESSLYTSSTATLTD- 736

Human   681 KKGSVAHRT-GTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGA 744
             .|:.|..: ||...|.:..:::|:         :...|..||
  Fly   737 -AGAAAGGSGGTAGGGARSKSLENV---------SGLALWSCE---------------------- 769

Human   745 IIYTVELKRYGGPLGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKG 805
             :..|::::.....|.:|...::|.|.    |:|..|.:||.||.|..|:.|||::::....|:|
  Fly   770 -VTAVDIEKTEQGFGFSILDYQDPLDSEGSVIVIRGLIRGGAAEATNEIYPGDRLMSVGDRLLQG 833

Human   806 KPLSEAIHLLQMAGETVT-LKIKKQTDAQSASSPKKFPISSHLSDLGD 852
            ..|.||:.:|:.....:| |.|.:...|..::|.     |:..|.|||
  Fly   834 LELDEAVSILKAMPPGLTRLGICRPLSASDSNSN-----SNIASPLGD 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	22/79 (28%)
		PDZ_signaling	227..310	CDD:238492	27/162 (17%)
		PDZ_signaling	325..408	CDD:238492	21/84 (25%)
		PDZ_signaling	545..633	CDD:238492	28/98 (29%)
		PDZ_signaling	646..730	CDD:238492	18/88 (20%)
		PDZ_signaling	746..827	CDD:238492	25/85 (29%)
		PDZ_signaling	1062..1142	CDD:238492
CG15803	NP_001287388.1	PDZ_signaling	17..89	CDD:238492	20/73 (27%)
		PDZ	307..393	CDD:214570	23/94 (24%)
		PDZ_signaling	605..680	CDD:238492	24/84 (29%)
		PDZ	773..858	CDD:214570	26/84 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900