DRSC/TRiP Functional Genomics Resources

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Protein Alignment CRB1 and LanA

DIOPT Version :10

Sequence 1:XP_016856341.1 Gene:CRB1 / 23418 HGNCID:2343 Length:1451 Species:Homo sapiens
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2034 Identity:391/2034 - (19%)
Similarity:574/2034 - (28%) Gaps:854/2034 - (41%)


- Green bases have known domain annotations that are detailed below.


Human    33 RCLSNSC--QNNSTCKDFSK----------------------DNDCSCSDTAN----NLD----- 64
            ||..::|  |.|..|..|.:                      .|:|...:..|    :||     
  Fly   297 RCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLDIHGHY 361

Human    65 ------KDCD-----------------------NMKDPCFSNPCQ-----GSATCVNTPGERSFL 95
                  ::|.                       |..|.|  :|||     .:..|....|.    
  Fly   362 DGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVC--SPCQCDYFFSTGHCEEETGN---- 420

Human    96 CKCPPGYSGTICET-TIGSCGKNSCQ---------HGGICHQDPIYPVCICPAGYAGRFCE---- 146
            |:|...:....|:: ..|..|..:|:         :|..|..:. ...|.|...:||.:|:    
  Fly   421 CECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAES-GQQCPCKINFAGAYCKQCAE 484

Human   147 --IDHDECASSPCQN-GAVCQD-GIDGYSCFCVPGYQGRHCD------LEVDECASDPCKNEAT- 200
              ....||.:..|.. |::..| .:....|.|:..:.|.:|:      .....|:...|.|:.| 
  Fly   485 GYYGFPECKACECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTE 549

Human   201 ---CLNEIGRYTCICPHNYSGVNCELEIDECW--------SQPC------LNGATCQDALGAYFC 248
               |..:.|:  |||...:.|..|    |:|.        .:||      .:..|| |..|.  |
  Fly   550 SEICNKQSGQ--CICREGFGGPRC----DQCLPGFYNYPDCKPCNCSSTGSSAITC-DNTGK--C 605

Human   249 DCAPGFLGDHCELNTDECASQP-CLHGGLCVDGENRYSCNCTGS-----GFTGTHCETLMPLCWS 307
            :|...|.|..|.|.|....|.| ||.......|....|||..|.     .|.|..|::.....::
  Fly   606 NCLNNFAGKQCTLCTAGYYSYPDCLPCHCDSHGSQGVSCNSDGQCLCQPNFDGRQCDSCKEGFYN 670

Human   308 KPCHNNATCEDS--VDNYT----------CHCWPGYTGAQCEIDLNECNS---NPCQSNGECVEL 357
            .|...:..|:.:  :|.:.          |.|....||..|    |||..   |...||.|..|:
  Fly   671 FPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRIC----NECKPLYWNLNISNTEGCEI 731

Human   358 SSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEE------DVNE-----CSSNPCQNGGT 411
            ......|.|:.|.:..|   .||. |.|:|...|..|:|      |::.     |....|..||:
  Fly   732 CDCWTDGTISALDTCTS---KSGQ-CPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGS 792

Human   412 ----CENLPGNYTCH-------CP-------FDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIP 458
                |:.:.|...||       |.       |..|.:..|...|.|           |.:||.:.
  Fly   793 WQSVCDKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYEYEDGS-----------LPSGTQVR 846

Human   459 HFQDGQHGFSCLCPSGYT-----------------GSLCEI------------ATTLSFEGD--- 491
            :..| :..|......||.                 .||..|            ..|:|...|   
  Fly   847 YDYD-EAAFPGFSSKGYVVFNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPL 910

Human   492 ----------------------GFLWVKSGSV---------TTKGSVCNIALRFQTVQPMAL--- 522
                                  |.|.||..::         |||.:. |:.|.:..:.|.|.   
  Fly   911 EVDQHVKVLLQPTSEPQFVTVAGPLGVKPSAIVLDPGRYVFTTKANK-NVMLDYFVLLPAAYYEA 974

Human   523 -LLFR--SNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLID 584
             :|.|  ||......:||...|.:.|::|                         |:.|.|..:|.
  Fly   975 GILTRHISNPCELGNMELCRHYKYASVEV-------------------------FSPAATPFVIG 1014

Human   585 DSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKID 649
            ::.|.....:..|..|..|.:     |.:|.:|| ::.:...|....::|.:..::..:      
  Fly  1015 ENSKPTNPVETYTDPEHLQIV-----SHVGDIPV-LSGSQNELHYIVDVPRSGRYIFVI------ 1067

Human   650 WNHITLENISSGSSLNVKAGCVRKDWCESQ------PCQSRGRC--------------------- 687
             ::|:..|......:|:|.    ||..:|:      ||.....|                     
  Fly  1068 -DYISDRNFPDSYYINLKL----KDNPDSETSVLLYPCLYSTICRTSVNEDGMEKSFYINKEDLQ 1127

Human   688 -----------------------INLWLSYQCDCHRPYEGPNCL---REYVAGRFGQDDSTGYVI 726
                                   ::.|   ..|...|  .|.|:   ::....:|.....:..:.
  Fly  1128 PVIISADIEDGSRFPIISVTAIPVDQW---SIDYINP--SPVCVIHDQQCATPKFRSVPDSKKIE 1187

Human   727 FT-------------------------LDESYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVW 766
            |.                         ||.....||.:...|...:|:  |..:....||     
  Fly  1188 FETDHEDRIATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPN--LFVILVKYYQ----- 1245

Human   767 LERGRLAMLTPNSPKLVVKFVLNDGN---------VHLISLK-----IKPYKIELYQSSQNLGFI 817
                      |:.||..|.:.|..|.         .|..|..     |:|.....::......|.
  Fly  1246 ----------PSHPKYQVYYTLTAGKNQYDGKFDIQHCPSSSGCRGVIRPAGEGSFEIDDEFKFT 1300

Human   818 -----SASTWKIEKGDVIYIGGLPDKQETELNGGFFKGCIQDVRLN---NQNLEFFPN------- 867
                 |.|.|      :.|:..:|.||..:           |:.:.   :|..||..|       
  Fly  1301 ITTDRSQSVW------LDYLVVVPLKQYND-----------DLLVEETFDQTKEFIQNCGHDHFH 1348

Human   868 PTNNASLNPVLVNVTQGCAGDNSCKRQTNVGRALTELGSRG--PKYQVSLFRFCVGSWATGNTFF 930
            .|:|||               :.||:..   .:||...:.|  |         |...:| |:|.|
  Fly  1349 ITHNAS---------------DFCKKSV---FSLTADYNSGALP---------CNCDYA-GSTSF 1385

Human   931 LSSIKPGSNPC--------HNGGVCHSRWDDF----SCSCPALTSGKACEEVQWCGFSPCPHGA- 982
              ...|....|        ...|.|.||:..|    .|.||   :...||..  .|...||... 
  Fly  1386 --ECHPFGGQCQCKPNVIERTCGACRSRYYGFPDCKPCKCP---NSAMCEPT--TGECMCPPNVI 1443

Human   983 -----QCQPVLQGF-------ECIAN--AVFNGQSGQILF------RSN--GNITRELTNITFGF 1025
                 :|.|...||       ||..|  .:.||.|...||      |.|  |......:|..|.|
  Fly  1444 GDLCEKCAPNTYGFHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNIEGRACDVCSNGYFNF 1508

Human  1026 RTRDANVIILHAE-----KEPEFLNISIQ-DSRLF-----------------FQLQSGN------ 1061
            .         |.|     |....|.:..: |...|                 :.||..|      
  Fly  1509 P---------HCEQCSCHKPGTELEVCDKIDGACFCKKNVVGRDCDQCVDGTYNLQESNPDGCTT 1564

Human  1062 ---------------SFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVD----NET--- 1104
                           ..|.:||....|:....:||.::..       ..|.:..|    |||   
  Fly  1565 CFCFGKTSRCDSAYLRVYNVSLLKHVSITTPEFHEESIKF-------DMWPVPADEILLNETTLK 1622

Human  1105 -PFVTSTIAT------GSLNFL---KDNTDIYVGDRA--IDNIKGLQG--------CLSTIEIGG 1149
             .|....:..      |.|::|   .::...|.||.|  :....|..|        .|.:.....
  Fly  1623 ADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGFDGKYIVAPDVILFSEHNAL 1687

Human  1150 IYLSY-------------------FENVHG------------------FINKPQEEQFLKISTNS 1177
            ::.||                   |:.:.|                  ||.....||.|....:.
  Fly  1688 VHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLKVIFIRANYWEQTLVTHLSD 1752

Human  1178 VV----------TG---CLQLNVCNSNPCLHGGNCEDIYSSYH---------------------- 1207
            |.          ||   .|.:..|:..|...|.:|||....|:                      
  Fly  1753 VYLTLADEDADGTGEYQFLAVERCSCPPGYSGHSCEDCAPGYYRDPSGPYGGYCIPCECNGHSET 1817

Human  1208 -------CS-CPLGWSGKHCELNID------------EC-------------FSNPCIHGNCSDR 1239
                   || |..|..|.|||..:.            :|             |:..|......|:
  Fly  1818 CDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESGDQ 1882

Human  1240 VAAYHCTCEPGYTGVNCEVDIDNCQSHQCANG--------------------------------- 1271
            :   ||.|:|||||..||         .||||                                 
  Fly  1883 I---HCECKPGYTGPRCE---------SCANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRT 1935

Human  1272 ---ATCISHTNGYSC-LCFGNFTGKFCRQSRLPSTVCGNEKTN--------LTCYN---GGNCTE 1321
               ..|:::|.|.:| ||...|.|...:.....|..|.:..|.        .||:.   |..|..
  Fly  1936 GECLRCLNNTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQTCDPFVGVCTCHENVIGDRCDR 2000

Human  1322 -------FQTEL---------------------KCMCRPGFTGEWCEKDIDECASD--------- 1349
                   |::.:                     .|.|:.|.||..|    |.||.|         
  Fly  2001 CKPDHYGFESGVGCRACDCGAASNSTQCDPHTGHCACKSGVTGRQC----DRCAVDHWKYEKDGC 2061

Human  1350 -PC-VNGGL-----CQDLLNKFQCLCDVAFAGERCE------------------------VDLAD 1383
             || .|.|.     |.....|.|||..|  .|:||:                        :|:.|
  Fly  2062 TPCNCNQGYSRGFGCNPNTGKCQCLPGV--IGDRCDACPNRWVLIKDEGCQECNNCHHALLDVTD 2124

Human  1384 DL---ISDIFTTIGSVTVA 1399
            .:   |..:.....|||:|
  Fly  2125 RMRYQIDSVLEDFNSVTLA 2143

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CRB1XP_016856341.1 EGF_CA 72..108 CDD:238011 9/40 (23%)
EGF_CA 148..183 CDD:238011 8/36 (22%)
EGF_CA 187..222 CDD:238011 10/38 (26%)
EGF_CA 225..260 CDD:238011 12/48 (25%)
EGF_CA 262..299 CDD:238011 12/42 (29%)
EGF_CA <309..337 CDD:238011 7/39 (18%)
EGF_CA 339..395 CDD:238011 18/58 (31%)
EGF_CA 397..438 CDD:214542 13/63 (21%)
Laminin_G_2 514..649 CDD:460494 25/140 (18%)
EGF_CA 676..707 CDD:238011 8/80 (10%)
Laminin_G_2 743..860 CDD:460494 24/138 (17%)
EGF_CA <939..968 CDD:238011 9/40 (23%)
Laminin_G_2 1025..1150 CDD:460494 32/195 (16%)
EGF_CA <1191..1220 CDD:238011 12/58 (21%)
EGF_CA 1222..1257 CDD:238011 12/59 (20%)
EGF_CA 1259..1294 CDD:238011 12/71 (17%)
EGF_CA 1342..1378 CDD:238011 16/51 (31%)
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012 6/16 (38%)
EGF_Lam 332..389 CDD:238012 6/56 (11%)
EGF_Lam 402..443 CDD:238012 10/44 (23%)
Laminin_EGF 448..497 CDD:395007 9/49 (18%)
Laminin_EGF 495..543 CDD:395007 8/47 (17%)
Laminin_EGF 541..589 CDD:395007 14/53 (26%)
Laminin_EGF 587..634 CDD:395007 16/49 (33%)
Laminin_EGF 632..679 CDD:395007 9/46 (20%)
Laminin_EGF 677..729 CDD:395007 14/55 (25%)
Laminin_EGF 732..782 CDD:395007 13/53 (25%)
EGF_Lam 785..828 CDD:238012 9/42 (21%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 25/147 (17%)
Laminin_EGF 1375..1423 CDD:395007 13/50 (26%)
EGF_Lam 1420..1457 CDD:238012 10/41 (24%)
Laminin_EGF 1466..1516 CDD:395007 15/58 (26%)
Laminin_EGF 1514..1562 CDD:395007 7/47 (15%)
LamB 1632..1760 CDD:214597 20/127 (16%)
Laminin_EGF <1775..1801 CDD:395007 7/25 (28%)
EGF_Lam 1808..1851 CDD:238012 8/42 (19%)
EGF_Lam 1859..1907 CDD:214543 17/59 (29%)
EGF_Lam 1916..1968 CDD:238012 8/51 (16%)
EGF_Lam 1969..2015 CDD:238012 8/45 (18%)
EGF_Lam 2016..>2054 CDD:238012 10/41 (24%)
EGF_Lam 2063..>2097 CDD:238012 13/35 (37%)
Laminin_I 2134..2385 CDD:310534 4/10 (40%)
SMC_prok_B 2356..>2705 CDD:274008
Laminin_II 2566..2700 CDD:368703
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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