Protein Alignment SIRT1 and Sirt1

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_062786.1
• Gene: Sirt1 / 93759
• MGIID: 2135607
• Length: 737
• Species: Mus musculus
• Alignment Length: 755
• Identity: 646/755 - (85%)
• Similarity: 681/755 - (90%)
• Gaps: 26/755 - (3%)

Human     1 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAAR 65
            ||||.|||||..||||||.| .||||.||.||||||||||||||.||||||..|.    .||||
Mouse     1 MADEVALALQAAGSPSAAAA-MEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAV----APAAA- 59

Human    66 GCPGAAA---AALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDD 127
            ||..|:|   |||||  ||..|||..|:||.|||.||:||||.||:   |||..||:.    |||
Mouse    60 GCEAASAAAPAALWR--EAAGAAASAEREAPATAVAGDGDNGSGLR---REPRAADDF----DDD 115

Human   128 EGEEEEE----AAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFV 188
            |||||:|    |||||||||||||..|.::||||||||||::||.||||||||||||||||||||
Mouse   116 EGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSSDWTPRPRIGPYTFV 180

Human   189 QQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQEC 253
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   181 QQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQEC 245

Human   254 KKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYP 318
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   246 KKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYP 310

Human   319 GQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAV 383
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   311 GQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAV 375

Human   384 RGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPV 448
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   376 RGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPV 440

Human   449 ALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEK 513
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   441 ALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEK 505

Human   514 PPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSN-DDLDVSESKGCMEE 577
            |||.||||.:||||||||||:||||||||||.|.|||||.||:|||..:| :||:|||| .|:||
Mouse   506 PPRPQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQATNNNVNDLEVSES-SCVEE 569

Human   578 KPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQY 642
            ||||||||||||:|  .:||||.|.|||||.:||||||||.|||||||||:||||||:||:||||
Mouse   570 KPQEVQTSRNVENI--NVENPDFKAVGSSTADKNERTSVAETVRKCWPNRLAKEQISKRLEGNQY 632

Human   643 LFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPD 707
            ||:|||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:.:
Mouse   633 LFVPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDTE 697

Human   708 VPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS 747
            .||.|||:|||.||.|||.:||||:.:||:||:||||:||
Mouse   698 RPECAGGSGFGADGGDQEVVNEAIATRQELTDVNYPSDKS 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		89/140 (64%)
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		212/272 (78%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139		91/143 (64%)
		Nuclear localization signal. /evidence=ECO:0000250	32..39		6/6 (100%)
		Nuclear export signal. /evidence=ECO:0000250	138..145		6/6 (100%)
		Interaction with CCAR2	143..541		384/397 (97%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		6/6 (100%)
		SIRT1	254..489	CDD:238699	233/234 (100%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		2/2 (100%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549		21/25 (84%)
		Phosphorylated at one of three serine residues	538..540		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587		18/25 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726		53/62 (85%)
Sirt1	NP_062786.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		43/59 (73%)
		Interaction with H1-4. /evidence=ECO:0000250|UniProtKB:Q96EB6	2..268		220/280 (79%)
		Interaction with CLOCK. /evidence=ECO:0000269|PubMed:18662547	2..131		91/143 (64%)
		Nuclear localization signal	32..39		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..125		33/56 (59%)
		Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6	135..533		384/397 (97%)
		Nuclear export signal	138..145		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..171		15/18 (83%)
		Nuclear localization signal	223..230		6/6 (100%)
		SIRT1	246..481	CDD:238699	233/234 (100%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000250|UniProtKB:Q96EB6	248..251		2/2 (100%)
		Nuclear export signal	425..431		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..539		20/24 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..713		51/59 (86%)