Protein Alignment SIRT1 and HST1

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_014573.1
• Gene: HST1 / 854086
• SGDID: S000005429
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 422
• Identity: 146/422 - (34%)
• Similarity: 217/422 - (51%)
• Gaps: 88/422 - (20%)

Human   150 DEIITNGFHSCESDEEDRAS------HASSSDWTPRPRIGPYTFVQQHLMIGTDPR------TIL 202
            |:.:....:|..:..::|:|      ||.:.|             :..|   |||.      .::
Yeast   119 DKELFMALNSNITSNKERSSAELSSIHAKAED-------------EDEL---TDPLEKKHAVKLI 167

Human   203 KDLLPETIPPPELDDMTLWQIVIN-ILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSV 266
            |||                |..|| :||   .|.:..:.|||:.....|:..|||:||||||||.
Yeast   168 KDL----------------QKAINKVLS---TRLRLPNFNTIDHFTATLRNAKKILVLTGAGVST 213

Human   267 SCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA 331
            |.|||||||.:|.|::  :....|.|||.:|:::.|.:||..|:..|..:.|.:...|..|.||.
Yeast   214 SLGIPDFRSSEGFYSK--IRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIK 276

Human   332 LSDKEGKLLRNYTQNIDTLEQVAGI--QRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPR 394
            :...:||||||||||||.||..|||  .:::|||||||||||:.|.:::..|.:..:|.|..:|.
Yeast   277 MLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPL 341

Human   395 CPRC-------------------------PADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVD 434
            ||.|                         |..:...::||::.||||.||.:||:.::.|..|.|
Yeast   342 CPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECD 406

Human   435 LLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIIN--------ELCH 491
            |||.||:||||.||:.|.:.:|..||||||||:.:.|..||:.|||.||.:.:        ::.|
Yeast   407 LLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVTHAEFDLNLLGFCDDVASLVAKKCHWDIPH 471

Human   492 RLGGEYAKLCCNPVKLSEIT---EKPPRTQKE 520
            :...:..|:..|..::.:.|   :|.||.:::
Yeast   472 KKWQDLKKIDYNCTEIDKGTYKIKKQPRKKQQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		35/130 (27%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		146/422 (35%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		3/7 (43%)
		SIRT1	254..489	CDD:238699	115/269 (43%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549
		Phosphorylated at one of three serine residues	538..540
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726
HST1	NP_014573.1	DUF592	53..207	CDD:368003	28/122 (23%)
		SIRT1	201..461	CDD:238699	115/261 (44%)