Protein Alignment SIRT1 and SIR2

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_010242.1
• Gene: SIR2 / 851520
• SGDID: S000002200
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 325
• Identity: 127/325 - (39%)
• Similarity: 175/325 - (53%)
• Gaps: 58/325 - (17%)

Human   224 VINILSEPPKRKKR-----KDIN-----------------TIEDAVKLLQECKKIIVLTGAGVSV 266
            |.|:  |.|..||:     ||:.                 ||:..::.|...:||:||||||||.
Yeast   205 VTNV--EDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQKLHTARKILVLTGAGVST 267

Human   267 SCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA 331
            |.|||||||.:|.|::  :....|.|||.:|:...|..||..|:..|..:.|.:...|..|.||.
Yeast   268 SLGIPDFRSSEGFYSK--IKHLGLDDPQDVFNYNIFMHDPSVFYNIANMVLPPEKIYSPLHSFIK 330

Human   332 LSDKEGKLLRNYTQNIDTLEQVAGI--QRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPR 394
            :...:||||||||||||.||..|||  .:::|||||||||:|:.|.:.:..|.:...|.|..:|.
Yeast   331 MLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPL 395

Human   395 CPRC------------------------PADEP------LAIMKPEIVFFGENLPEQFHRAMKYD 429
            ||.|                        .::.|      ..::||:|.||||.||.:||::::.|
Yeast   396 CPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIRED 460

Human   430 KDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLG 494
            ..|.||||.||:||||.||:.|.:.:|..|||:||||:|:.|..||:.|||.||.|...:..:.|
Yeast   461 ILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCG 525

Human   495  494
            Yeast   526  525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		21/65 (32%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		127/325 (39%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		2/5 (40%)
		SIRT1	254..489	CDD:238699	115/266 (43%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549
		Phosphorylated at one of three serine residues	538..540
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726
SIR2	NP_010242.1	DUF592	104..261	CDD:368003	14/57 (25%)
		SIRT1	255..517	CDD:238699	114/263 (43%)