Protein Alignment SIRT1 and sirt1

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: XP_001334440.5
• Gene: sirt1 / 797132
• ZFINID: ZDB-GENE-070801-2
• Length: 742
• Species: Danio rerio
• Alignment Length: 807
• Identity: 393/807 - (48%)
• Similarity: 473/807 - (58%)
• Gaps: 173/807 - (21%)

Human    17 AAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEA 81
            |.|.::.|.|:...|||.|:||.    ||.|
Zfish     2 ADGENKRAESAEPDEPLPKKPRL----LELS---------------------------------- 28

Human    82 EAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEG---EEEEEAAAAAIGYR 143
                  |:.|..|||.|...|..|.....|::....:|..:....:.|   :.|.|.:.
Zfish    29 ------GDSEHSATAGADTLDEKPARMDESQQALSINNNNNTRPTEPGQPADPEPEISE------ 81

Human   144 DNLLFGDEIITNGFHSCE--SDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLL 206
               |..:.:.:|||.|.:  .|::|.:|.||||||||:|:||.|.|:|||:|.|||||.||||||
Zfish    82 ---LTDEGVHSNGFTSPDLLRDDDDCSSRASSSDWTPQPQIGSYRFIQQHIMRGTDPRAILKDLL 143

Human   207 PETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIP 271
            |||:.||:|||||||||:||| ||||||||||||||:||.|:||.|.|||:||||||||||||||
Zfish   144 PETVLPPDLDDMTLWQIIINI-SEPPKRKKRKDINTLEDVVRLLNERKKILVLTGAGVSVSCGIP 207

Human   272 DFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKE 336
            ||||||||||||||||||||||||||||:|||:||||||||||||||||||||.||:||::.||:
Zfish   208 DFRSRDGIYARLAVDFPDLPDPQAMFDIDYFRRDPRPFFKFAKEIYPGQFQPSPCHRFISMLDKK 272

Human   337 GKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPAD 401
            |:|||||||||||||||||||:|||||||||||||||||:||||||:|.||||||||.|||||:|
Zfish   273 GRLLRNYTQNIDTLEQVAGIQKIIQCHGSFATASCLICKHKVDCEAIREDIFNQVVPHCPRCPSD 337

Human   402 EPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINR 466
            .|.|||||:||||||||||.||||||.|||||||||||||||||||||||||||||:|||:||||
Zfish   338 VPYAIMKPDIVFFGENLPEFFHRAMKQDKDEVDLLIVIGSSLKVRPVALIPSSIPHDVPQVLINR 402

Human   467 EPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKP----------------- 514
            ||||||:||||||||||||:|||||||.|::.:||.|..:||||||||
Zfish   403 EPLPHLNFDVELLGDCDVIVNELCHRLNGDFQQLCYNSSRLSEITEKPAAPEHTENTSADHSHAD 467

Human   515 ---------PRTQKELAYLSELPPTPLHV-------------SEDSSSPERTSPPDSSVIVTLLD 557
                     .|...:..::........|.             ..|:...|.||...|......::
Zfish   468 AEHIENTSADRDDADAEHIENTSADHSHADAEHIENTSADRDDADAEHIENTSADHSHADAEHIE 532

Human   558 QAAKSNDDLDVSE----------------------------SKGCMEEKPQEVQTSRNVESIA-- 592
            ..:...||.:.:|                            |......|..:...|.|.|.:|
Zfish   533 NTSADRDDAEHTENTPTDHANAEHTEHTSAGHVNAEHIEHMSTDHANAKDDQSSLSVNEEELASP 597

Human   593 ----------------EQMENPDLKNVGSSTGEKNERTSVAGTV---RKCWPNRVAKEQISRRLD 638
                            |:.:..|..|...:...|:|..:....|   |:||.:|:.:..||:||.
Zfish   598 AAETHALDSTEISAHTERSKEADAVNTDDAACVKDEENTDRLRVEMRRRCWRSRICQSPISKRLG 662

Human   639 GNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLE 703
            .:||||..||||:||||||||.|||:  |||||.|.|| |:.|        .::||:||
Zfish   663 ASQYLFQAPNRYVFHGAEVYSSSEDE--SSSSCSSESD-GSFQ--------HEDSEVEE------ 710

Human   704 DEPDVPERAGGAGFGTDGDDQEAINEA 730
                     .||.......|.|.:.::
Zfish   711 ---------NGAAMTDKETDTETVQDS 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		25/120 (21%)
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		111/255 (44%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139		26/124 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	32..39		4/6 (67%)
		Nuclear export signal. /evidence=ECO:0000250	138..145		0/6 (0%)
		Interaction with CCAR2	143..541		303/438 (69%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		4/6 (67%)
		SIRT1	254..489	CDD:238699	209/234 (89%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		1/2 (50%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549		5/38 (13%)
		Phosphorylated at one of three serine residues	538..540		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587		6/52 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726		18/62 (29%)
sirt1	XP_001334440.5	None