Protein Alignment SIRT1 and sir2

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_001018840.1
• Gene: sir2 / 3361342
• PomBaseID: SPBC16D10.07C
• Length: 475
• Species: Schizosaccharomyces pombe
• Alignment Length: 428
• Identity: 162/428 - (37%)
• Similarity: 228/428 - (53%)
• Gaps: 58/428 - (13%)

Human   161 ESDEEDRASHASSSDWTPRPRIGPY-------TFVQQHLMIGTDP-RTILKDL---LPETIPPPE 214
            :|||.|:....:.||...|..:..|       .|::::|:....| |:|||.|   ||..:  .|
pombe    54 DSDEWDKPETENISDLDERSEMVRYLRASGYAKFLEKYLIEEELPVRSILKKLGINLPSAL--EE 116

Human   215 LDDMTLWQIVINILS-EPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDG 278
            .:|:.|..::..:|. |..:|.|....||.||.|.||::.|.::||.|||:|.|.||.||||.:|
pombe   117 FEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNG 181

Human   279 IYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYP--GQFQPSLCHKFIALSDKEGKLLR 341
            .|||||..  .|.:|..||||..||::|..|:.||:::.|  ..:.||  |.||.|.:|:.||..
pombe   182 FYARLARH--GLSEPSEMFDIHTFRENPEIFYTFARDLLPETNHYSPS--HAFIRLLEKKNKLST 242

Human   342 NYTQNIDTLEQVAGI--QRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRC------ 398
            .:|||||.||:..|:  .:|||||||||||:|:.||:|||...:..||.||.|..|..|
pombe   243 LFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQRVSYCNECGKPPLK 307

Human   399 --------------------PADEPLA---IMKPEIVFFGENLPEQ-FHRAMKYDKDEVDLLIVI 439
                                .:::.||   ||||:|.||||.||:. |::....:.:|.||||.|
pombe   308 LRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSGELEETDLLICI 372

Human   440 GSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGD-CDVIINELCHRLG--GEYAKLC 501
            |:||||.||:.:.|.||...|||.|:|.|:.|..|||..|.. ||.:|.|:|.|.|  .|...||
pombe   373 GTSLKVAPVSELISVIPPTTPQIYISRTPVRHTQFDVNFLSPYCDWVIVEICKRAGWLNELQALC 437

Human   502 CNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSS 539
            ..|...|....:...|..::.:..   |:..|::..::
pombe   438 DLPECHSGSKTRAFETDLDIKFEE---PSTYHITSTTN 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		39/118 (33%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139
		Nuclear localization signal. /evidence=ECO:0000250	32..39
		Nuclear export signal. /evidence=ECO:0000250	138..145
		Interaction with CCAR2	143..541		162/428 (38%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		1/7 (14%)
		SIRT1	254..489	CDD:238699	118/269 (44%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		0/2 (0%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549		2/17 (12%)
		Phosphorylated at one of three serine residues	538..540		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726
sir2	NP_001018840.1	DUF592	70..162	CDD:368003	27/93 (29%)
		SIRT1	157..420	CDD:238699	117/266 (44%)