Protein Alignment SIRT1 and Sirt1

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: NP_001401888.1
• Gene: Sirt1 / 309757
• RGDID: 1308542
• Length: 741
• Species: Rattus norvegicus
• Alignment Length: 754
• Identity: 656/754 - (87%)
• Similarity: 684/754 - (90%)
• Gaps: 23/754 - (3%)

Human     1 MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAAR 65
            ||||||||||.|||||||.| .||||.||.||||||||||||||.||||||..||   ...|||.
  Rat     1 MADEAALALQAGGSPSAAAA-MEAASQPADEPLRKRPRRDGPGLGRSPGEPSAAA---AAAAAAA 61

Human    66 GCPGAAA---AALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDD 127
            ||..|:|   ||||||| |.||||..|:||.||||||:|||||||:   |||..||:.    |||
  Rat    62 GCEAASAAAPAALWREA-AGAAAASAEREAPATAAAGDGDNGPGLR---REPRAADDF----DDD 118

Human   128 EGEEEEE---AAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQ 189
            |||||:|   |||||||||||||..||||||||||||||::||||||||||||||||||||||||
  Rat   119 EGEEEDEAAAAAAAAIGYRDNLLLADEIITNGFHSCESDDDDRASHASSSDWTPRPRIGPYTFVQ 183

Human   190 QHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECK 254
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   184 QHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECK 248

Human   255 KIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPG 319
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   249 KIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPG 313

Human   320 QFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVR 384
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   314 QFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVR 378

Human   385 GDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVA 449
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   379 GDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVA 443

Human   450 LIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKP 514
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   444 LIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKP 508

Human   515 PRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSN-DDLDVSESKGCMEEK 578
            |||||||.:||||||||||:||||||||||.|.|||||.||:||..|:. |||:|||.|.|:|||
  Rat   509 PRTQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQTIKNKVDDLEVSEPKSCVEEK 573

Human   579 PQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYL 643
            .|||||.||||||  .:||||.|.||||||:||||||||.|||||||||:||||||:||||||||
  Rat   574 SQEVQTYRNVESI--NVENPDFKAVGSSTGDKNERTSVAETVRKCWPNRLAKEQISKRLDGNQYL 636

Human   644 FLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDV 708
            |:|||||||||||||||||||.|||||||||||||||||||||||:|||||||||||||||:.|.
  Rat   637 FVPPNRYIFHGAEVYSDSEDDALSSSSCGSNSDSGTCQSPSLEEPLEDESEIEEFYNGLEDDADR 701

Human   709 PERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS 747
            ||.|||:  |.||.||||:||||::|||:||:|...:||
  Rat   702 PECAGGS--GADGGDQEAVNEAIAMKQELTDVNCTPDKS 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		95/139 (68%)
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		222/271 (82%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139		97/142 (68%)
		Nuclear localization signal. /evidence=ECO:0000250	32..39		6/6 (100%)
		Nuclear export signal. /evidence=ECO:0000250	138..145		6/6 (100%)
		Interaction with CCAR2	143..541		390/397 (98%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		6/6 (100%)
		SIRT1	254..489	CDD:238699	234/234 (100%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		2/2 (100%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549		21/25 (84%)
		Phosphorylated at one of three serine residues	538..540		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587		16/25 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726		51/62 (82%)
Sirt1	NP_001401888.1	SIRT1	248..483	CDD:238699	234/234 (100%)