Protein Alignment SIRT1 and sirt1

DIOPT Version :10

• Sequence 1: NP_036370.2
• Gene: SIRT1 / 23411
• HGNCID: 14929
• Length: 747
• Species: Homo sapiens
• Sequence 2: XP_012821550.2
• Gene: sirt1 / 100145679
• XenbaseID: XB-GENE-989003
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 732
• Identity: 438/732 - (59%)
• Similarity: 510/732 - (69%)
• Gaps: 90/732 - (12%)

Human    13 GSPSAAGADRE---------AASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCP 68
            ||...|.:||.         |.|...||||.||.|.:..|
 Frog    65 GSGKMADSDRVGFPIAGAVLAVSKENGEPLSKRQRLEDTG------------------------- 104

Human    69 GAAAAALWREAEAEAA----AAGGEQEAQATAA---AGEGDNGPGLQGPSREPPLADNLYDEDDD 126
            |..:..:..|:|.:||    ||..::|.:|::|   .....||.|.||      |....|.....
 Frog   105 GGGSQLVGAESEGKAALPPIAASLQEEGEASSAMESKSRAHNGSGFQG------LPLGTYLVQGQ 163

Human   127 DEGEEEE----EAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTF 187
            :||..||    :.:..|:.|...:...|: :..|||||:|:::|.|||||||||.|||.||||||
 Frog   164 EEGGAEEMPNGDLSDQAVDYGAGIHLDDD-LAGGFHSCDSEDDDGASHASSSDWAPRPCIGPYTF 227

Human   188 VQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQE 252
            ||:|||:|||||||||||||:|:.|.||||||||||||||||:|||||||||||||:||||||||
 Frog   228 VQRHLMMGTDPRTILKDLLPDTVAPSELDDMTLWQIVINILSDPPKRKKRKDINTIDDAVKLLQE 292

Human   253 CKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIY 317
            .||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||:
 Frog   293 SKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIF 357

Human   318 PGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEA 382
            ||||||||||:|||:.|||.|||||||||||||||||||::|||||||||.||||:|||||||||
 Frog   358 PGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVDCEA 422

Human   383 VRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRP 447
            ||.|||||:|||||||.:|||||||||:||||||||||||||||||||:||||||||||||||||
 Frog   423 VREDIFNQIVPRCPRCSSDEPLAIMKPDIVFFGENLPEQFHRAMKYDKNEVDLLIVIGSSLKVRP 487

Human   448 VALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITE 512
            ||||||||||||||||||||||||||||:||||||||||||||.||.|:|::||.|.:|||:|||
 Frog   488 VALIPSSIPHEVPQILINREPLPHLHFDIELLGDCDVIINELCQRLDGKYSQLCTNSLKLSQITE 552

Human   513 KPPRTQKELAYLSE-LPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCME 576
            ||||..|......| :|.|.|:..:   ||..              |:.....||.:|.|.....
 Frog   553 KPPRIHKGFLTSPETVPSTDLNTGQ---SPAL--------------QSDLRGTDLQLSASNTMRS 600

Human   577 -EKPQEVQ------TSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGT---VRKCWPNRVAKE 631
             |||:|..      :..|:|...|  .|..|.|      ||::.|:...|   ..|...::..||
 Frog   601 LEKPEEASKLSHNCSEENLEVSKE--ANTQLSN------EKDQETAEKDTDIDSAKDLESKYTKE 657

Human   632 QISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIE 696
            |||:|||..|:|||.|||||||||||:|||::| |:|||||:||||.:..||||.||:|::|:.|
 Frog   658 QISKRLDSTQFLFLAPNRYIFHGAEVFSDSDED-LTSSSCGTNSDSESLLSPSLHEPIEEDSDTE 721

Human   697 E-FYNGLEDEPDVPERA 712
            | |:...|:|.|...||
 Frog   722 ECFHAKYENETDTDNRA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT1	NP_036370.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..135		36/141 (26%)
		Interaction with H1-4. /evidence=ECO:0000269|PubMed:15469825	2..268		134/274 (49%)
		Interaction with CLOCK. /evidence=ECO:0000250|UniProtKB:Q923E4	2..139		36/145 (25%)
		Nuclear localization signal. /evidence=ECO:0000250	32..39		4/6 (67%)
		Nuclear export signal. /evidence=ECO:0000250	138..145		2/6 (33%)
		Interaction with CCAR2	143..541		325/398 (82%)
		Nuclear localization signal. /evidence=ECO:0000250	223..230		6/6 (100%)
		SIRT1	254..489	CDD:238699	217/234 (93%)
		Required for interaction with the sumoylated form of CCAR2. /evidence=ECO:0000269|PubMed:25406032	256..259		2/2 (100%)
		Nuclear export signal. /evidence=ECO:0000250	425..431		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..549		6/26 (23%)
		Phosphorylated at one of three serine residues	538..540		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..587		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..726		27/51 (53%)
sirt1	XP_012821550.2	SIRT1	294..529	CDD:238699	217/234 (93%)