Protein Alignment SIRT4 and Sirt7

DIOPT Version :10

• Sequence 1: NP_036372.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_651664.2
• Gene: Sirt7 / 43433
• FlyBaseID: FBgn0039631
• Length: 771
• Species: Drosophila melanogaster
• Alignment Length: 286
• Identity: 78/286 - (27%)
• Similarity: 124/286 - (43%)
• Gaps: 60/286 - (20%)

Human    36 SPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAP 100
            :|.:...||::|...|:.:|.|:..|||||||.:.|||||..: |::..     :|.|
  Fly   105 APHVIEAKVEQLANIISQAKHLVCYTGAGISTAALIPDYRGSQ-GIWTL-----LQKG------- 156

Human   101 IRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LTELHGC 163
                    ..:|....||..|...|.||....:...|:.:|:||.|.||.::|..|  |:|:||.
  Fly   157 --------QDIGEHDLSSANPTYTHMALYELHRRRLLHHVVSQNCDGLHLRSGLPRNSLSEIHGN 213

Human   164 MDRVLCLDCGEQTPRGVLQERFQVLNPT--WSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGH 226
            |...:|.:|   .|..|...:|.....|  :..:.|.|                    |.:|...
  Fly   214 MYVEVCKNC---RPNSVYWRQFDTTEMTARYCHKTHRL--------------------CHRCSEP 255

Human   227 LKPDVVFFGDTVN---PDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLP------I 282
            |...:|.||:..|   |..........:.||.:|.:||||:|...|.::   |:...|      |
  Fly   256 LYDTIVHFGERGNVKWPLNWAGATANAQRADVILCLGSSLKVLKKYTWL---WQMDRPARQRAKI 317

Human   283 AILNIGPTRSDDLACLKLNSRCGELL 308
            .::|:..|..|.:|.:|:|.:|.:::
  Fly   318 CVVNLQWTPKDAIASIKINGKCDQVM 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT4	NP_036372.1	SIRT4	47..308	CDD:238700	75/273 (27%)
		sirtuin core domain	55..314		73/267 (27%)
Sirt7	NP_651664.2	SIRT7	124..338	CDD:238701	72/260 (28%)