Protein Alignment SIRT4 and Sirt6

DIOPT Version :10

• Sequence 1: NP_036372.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Sequence 2: NP_649990.2
• Gene: Sirt6 / 41254
• FlyBaseID: FBgn0037802
• Length: 325
• Species: Drosophila melanogaster
• Alignment Length: 284
• Identity: 72/284 - (25%)
• Similarity: 121/284 - (42%)
• Gaps: 81/284 - (28%)

Human    42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDR--RPIQHGDFVRSAPIRQR 104
            ||.:||...|..|..:::.|||||||.:||||:|..| |::...::  :|    ||..|
  Fly    32 EKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPK-GVWTLEEKGEKP----DFNVS------ 85

Human   105 YWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRR--LTELHGCMDRV 167
                       |...:|...|.|:....:.|.:.::::||:|.||.|:|..|  |:||||.:...
  Fly    86 -----------FDEARPTKTHMAIIALIESGYVQYVISQNIDGLHLKSGLDRKYLSELHGNIYIE 139

Human   168 LCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVV 232
            .|..|           |.|.::|: :.|..|          ::.::.....:....|...:..::
  Fly   140 QCKKC-----------RRQFVSPS-AVETVG----------QKSLQRACKSSMDSKGRSCRSGIL 182

Human   233 FFGDTV---------NPDKVDFVHKRVKEADSLLVVGSSLQVY-SGYRFILTAWEKKLPI----- 282
            :  |.|         |..::..:|..|  ||..:.:|::||:. ||          .||:
  Fly   183 Y--DNVLDWEHDLPENDLEMGVMHSTV--ADLNIALGTTLQIVPSG----------DLPLKNLKC 233

Human   283 ----AILNIGPTRSDDLACLKLNS 302
                .|.|:.||:.|..|.|.::|
  Fly   234 GGKFVICNLQPTKHDKKANLIISS 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIRT4	NP_036372.1	SIRT4	47..308	CDD:238700	69/279 (25%)
		sirtuin core domain	55..314		66/271 (24%)
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	66/271 (24%)