Protein Alignment DICER1 and Dcr-1

DIOPT Version :10

• Sequence 1: NP_085124.2
• Gene: DICER1 / 23405
• HGNCID: 17098
• Length: 1922
• Species: Homo sapiens
• Sequence 2: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Alignment Length: 2423
• Identity: 768/2423 - (31%)
• Similarity: 1097/2423 - (45%)
• Gaps: 728/2423 - (30%)

Human    32 WQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRT 96
            |....:|..::|||.:|||||..|.:.|||:||...|.|.|||:.|.:|||.:.|    |:|:.:
  Fly     5 WCDNNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRAR----RHGRVS 65

Human    97 VFL---VNSANQVAQQVSAVRTH-SDLKVGEYSNLEVNASWTKERWNQE----------FTKHQV 147
            |:|   |.::.:.. .:..:.|| :||:|                |.::          :|.:.|
  Fly    66 VYLSCEVGTSTEPC-SIYTMLTHLTDLRV----------------WQEQPDMQIPFDHCWTDYHV 113

Human   148 LIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCEN----CPSC--PRILGLT 206
            .|:.....|.:|:...|.||.:.|:|.::||.:.:   |:.|..|.||    .|..  ||||||.
  Fly   114 SILRPEGFLYLLETRELLLSSVELIVLEDCHDSAV---YQRIRPLFENHIMPAPPADRPRILGLA 175

Human   207 ASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLL 271
            ..:.:..|:.::|...:..||:.:....|||:|:|.:.||.|:|.|.:|.|.||.     .:.|.
  Fly   176 GPLHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQCAPFE-----MDELS 235

Human   272 MELEEALN----FINDCN---ISVHSKER---------DSTLISKQILSDCRAVLVVLGPWCADK 320
            :.|.:.||    |:.|..   ..::..::         |..:....:::....||..:||||..:
  Fly   236 LVLADVLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQR 300

Human   321 VAGMMVR---ELQKYIKHEQEELHRKFLLF--TDTFLRKIHALCEEHF---------SPASLDLK 371
            .|....:   :|:....||     |.:||:  ..|.|.::::|||..|         |..::: :
  Fly   301 AAHHFYQCNEKLKVKTPHE-----RHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIE-R 359

Human   372 FVTPKVIKLLEILRKYKPYE-----------RQQFESVEWYNNR--------------------- 404
            :.:|||.:||:.||.:||.|           |.|.:..::  ||
  Fly   360 YSSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADF--NRLSHTLESKCRMVDQMDQPPTE 422

Human   405 --------------NQDNYVSWSDSEDDDEDEEIEEKEKPET--NFPSPFT-------------- 439
                          .:|...:.|.:...........|.||.:  |...|.|
  Fly   423 TRALVATLEQILHTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHN 487

Human   440 ---NILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQ 501
               :.||.:|:..:.:||.||..|:.|..::||:|.::...:.|.. :.......|:.|.|.|:|
  Fly   488 DGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDR-VADPTTEPKEAELEHRRQ 551

Human   502 EEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML--- 563
            ||||::||.|:.|:||.||::|||:|:||||||||:|.||.||||||.||||||..:.:::|
  Fly   552 EEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAP 616

Human   564 ----------------------------ADTD--------------------------------- 567
                                        ||:|
  Fly   617 SYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFS 681

Human   568 ---------KIKSFEEDLKT--------------------------------------------- 578
                     |::..:::|..
  Fly   682 KQPPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPED 746

Human   579 ---------------------------YKAIEKILRNKCSKSVDTGETDIDPVMDDDDVF----- 611
                                       |:.||::|.:||:.:.       .|..:..:..
  Fly   747 TSDTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTE-------PPEQEQSEAERFSAC 804

Human   612 ------PPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAP--KCRTRELPDGT-FYSTL 667
                  .|::|.    |..|.:.:||..:|:||||||||.||.|..  :|...|....| |..||
  Fly   805 LAAYRPKPHLLT----GASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNERAGVTLFQYTL 865

Human   668 YLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEE------EL 726
            .|||||||:..|||.||....||.|:.||..|.:||:||||||.|.|:|||..:..|      ||
  Fly   866 RLPINSPLKHDIVGLPMPTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFEL 930

Human   727 DLHDEE--ETSVPGRPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRR 789
            :..||:  :.|...|||:|||||.|.|.|.....|..|....|||||.|.:.|..|:|:|.|.|.
  Fly   931 EPEDEQIVQLSDEPRPGTTKRRQYYYKRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRG 995

Human   790 RKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLELITRLHQYIF 854
            ||:|||||..:.|||||.|.||::..|.::||||||.:|:||.|...:|:.:.:..|.....|.|
  Fly   996 RKIYPPEDAQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLNYTF 1060

Human   855 SHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARI--GIPSTKYTKE 917
            :::|||:|..:.|.|...::...::| .|...:....||::|:|.|:.:...:  .:|..:...:
  Fly  1061 TNVLRLQKFLMLFDPDSTENCVFIVP-TVKAPAGGKHIDWQFLELIQANGNTMPRAVPDEERQAQ 1124

Human   918 TPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTN 982
            .   |..:.:||||::|.|||.|||..||||::...|:|||.||...|.||..||..||.|.:.|
  Fly  1125 P---FDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQN 1186

Human   983 LNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASL 1047
            .:||||||||||:|||.||||::|:||.|||.||.|.::||.|:|:.|||||||||.:||.||||
  Fly  1187 TSQPLLDVDHTSARLNFLTPRYVNRKGVALPTSSEETKRAKRENLEQKQILVPELCTVHPFPASL 1251

Human  1048 WRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSL-PADFRYPNLDFGW------KKSIDSK 1105
            ||.|||||.||||::.||.|:::|.|.::|.|:|.:.: ..||.:|.|||||      |||.:||
  Fly  1252 WRTAVCLPCILYRINGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESK 1316

Human  1106 SFISISNSSSAENDNYCKHSTIVPENAAHQGANRTSSL------ENHDQMSVNCRTLLSESPGKL 1164
            ...|:            |..||..::.|......||..      ...|::..:...|:.|...||
  Fly  1317 QKESL------------KDDTINGKDLADVEKKPTSEETQLDKDSKDDKVEKSAIELIIEGEEKL 1369

Human  1165 H-----VEV---SADLTAINGLSYNQ---------------------------------NLANGS 1188
            .     :|:   |.|: |.:..|:||                                 :::||.
  Fly  1370 QEADDFIEIGTWSNDM-ADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGE 1433

Human  1189 YDLANRDFCQGNQLNYYKQEIPVQPTTSY------------------------------------ 1217
            .........|..|....|.:.|.:||.:|
  Fly  1434 SGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVAD 1498

Human  1218 ---------------------------------------------SIQNL-----YSYENQPQPS 1232
                                                         ..:||     :.:|:|.:|:
  Fly  1499 DIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPA 1563

Human  1233 ----------------------------------------------------------------- 1232
                                                                             
  Fly  1564 TIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAKVSMMELLKQLLPYVNEDVLAKKL 1628

Human  1233 -DECTLLSNKYLDGNANKSTSDGSPVMAVM---------------------------------PG 1263
             |...||.:..::.||:...........||                                 |.
  Fly  1629 GDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPT 1693

Human  1264 TTDTI--QVLKGRMDSEQSPS-IGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKH 1325
            :|..|  .:|......::.|. :|:.    ||:|.:||||||:|||:||.||||||.:||||||:
  Fly  1694 STKAITSAILPAGFSFDRQPDLVGHP----GPSPSIILQALTMSNANDGINLERLETIGDSFLKY 1754

Human  1326 AITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQD 1390
            ||||||:.||.:.|||:||::|||:|:|.||||||::|.|...|:.:.|:|..|||||.|.|
  Fly  1755 AITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYV--- 1816

Human  1391 KSNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDN 1455
                                                     |||   .|...:|
  Fly  1817 -----------------------------------------PKE---LEKALIE----------- 1826

Human  1456 MLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEE 1520
                     .||         ..:.||:            :|..|....|...:|     :.|.|
  Fly  1827 ---------AKI---------PTHHWKL------------ADLLDIKNLSSVQIC-----EMVRE 1856

Human  1521 DDFVVGFWNPSEENCGVDTGKQS------------ISYDLHTEQCIADKSIADCVEALLGCYLTS 1573
            ....:|.    |:|.|...|:..            |.|:|.::..|.|||||||||||:|.||..
  Fly  1857 KADALGL----EQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIE 1917

Human  1574 CGERAAQLFLCSLGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSE 1638
            ||.|.|.||:..||::|||:.::.|          ..|.:|:      ...|...:..:|:  :.
  Fly  1918 CGPRGALLFMAWLGVRVLPITRQLD----------GGNQEQR------IPGSTKPNAENVV--TV 1964

Human  1639 YGCLKIP--PRCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCY 1701
            ||....|  |...| .|:|.:.|:.|:||||.||:.:.|:|::::|||||.|||||..|.:||||
  Fly  1965 YGAWPTPRSPLLHF-APNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCY 2028

Human  1702 QRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELF 1766
            |||||||||:||||||:||||||||||||.|||||||||||||||||||::.:||:|:.:||.|.
  Fly  2029 QRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLN 2093

Human  1767 HVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVW 1831
            .|||.||:.|.|.......:..| .|||:.:..||:|||||:||:|||:||||::||.|||:.||
  Fly  2094 DVIDRFVRIQQENGHCISEEYYL-LSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVW 2157

Human  1832 QVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDG-KVRVTVEVVGKGKFKGVGR 1895
            .||..||.|.||:||.:||:||:|||||:|||||||...|:..|| :|||||:|..||.|:|:||
  Fly  2158 HVYSNMMSPEIEQFSNSVPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGR 2222

Human  1896 SYRIAKSAAARRALRSLK 1913
            :|||||..||:.|||.||
  Fly  2223 NYRIAKCTAAKCALRQLK 2240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DICER1	NP_085124.2	DEXHc_dicer	42..239	CDD:350792	66/216 (31%)
		DECH box	175..178		0/2 (0%)
		Required for interaction with PRKRA and TARBP2	256..595		121/578 (21%)
		Dicer_PBD	271..365	CDD:277191	25/123 (20%)
		SF2_C_dicer	372..564	CDD:350189	80/287 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		4/25 (16%)
		Dicer_dimer	630..718	CDD:460900	49/90 (54%)
		PAZ_dicer_like	886..1008	CDD:239209	55/123 (45%)
		RIBOc	1296..>1387	CDD:197778	58/90 (64%)
		RIBOc	1682..1846	CDD:238333	108/163 (66%)
		DSRM_DICER	1851..1913	CDD:380680	39/62 (63%)
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120	66/216 (31%)
		Dicer_PBD	240..344	CDD:277191	23/108 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819	57/124 (46%)
		Dicer_dimer	825..916	CDD:460900	49/90 (54%)
		PAZ_dicer_like	1091..1212	CDD:239209	55/123 (45%)
		RIBOc	1724..1930	CDD:238333	103/302 (34%)
		RIBOc	2008..2172	CDD:238333	108/164 (66%)
		DSRM_DICER	2177..2240	CDD:380680	39/62 (63%)