DRSC/TRiP Functional Genomics Resources

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Protein Alignment DICER1 and mRpL44

DIOPT Version :10

Sequence 1:NP_085124.2 Gene:DICER1 / 23405 HGNCID:17098 Length:1922 Species:Homo sapiens
Sequence 2:NP_649541.1 Gene:mRpL44 / 40656 FlyBaseID:FBgn0037330 Length:321 Species:Drosophila melanogaster


Alignment Length:181 Identity:41/181 - (22%)
Similarity:68/181 - (37%) Gaps:50/181 - (27%)


- Green bases have known domain annotations that are detailed below.


Human  1769 IDDFVQFQLEK--NE-MQGMDSELRRSEE---------DEEKEEDIEVP---KAMGDIFESLAGA 1818
            ::.|:|.||.|  || :|.:.|.|..:|.         .::..:..|.|   ::......::.||
  Fly   130 VEAFLQHQLPKVPNEGLQAIASYLLSTETLAHVSTHLGTKDLIQSTEYPPSAESQAKSLHAVIGA 194

Human  1819 IYMDSGM------------------SLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEP--- 1862
            :...||:                  .|..||....|:.  |:||....      |:|.|.||   
  Fly   195 LASSSGIERAFIFVRDFICTQLNQKDLLEVWTPQEPIQ--LLEKICQE------RKLGEAEPRLL 251

Human  1863 -ETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSL 1912
             :..| :.....|...:....:::|    ||.|...:.|...||..||:|:
  Fly   252 GDCGK-NTVLAAYQVGIYANRQLLG----KGFGEDVKTATETAALDALQSI 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DICER1NP_085124.2 DEXHc_dicer 42..239 CDD:350792
DECH box 175..178
Required for interaction with PRKRA and TARBP2 256..595
Dicer_PBD 271..365 CDD:277191
SF2_C_dicer 372..564 CDD:350189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..433
Dicer_dimer 630..718 CDD:460900
PAZ_dicer_like 886..1008 CDD:239209
RIBOc 1296..>1387 CDD:197778
RIBOc 1682..1846 CDD:238333 24/109 (22%)
DSRM_DICER 1851..1913 CDD:380680 17/66 (26%)
mRpL44NP_649541.1 RIBOc 81..219 CDD:197778 17/88 (19%)
DSRM_MRPL44 217..300 CDD:380703 24/94 (26%)
Blue background indicates that the domain is not in the aligned region.

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