Protein Alignment DICER1 and drosha

DIOPT Version :10

• Sequence 1: NP_085124.2
• Gene: DICER1 / 23405
• HGNCID: 17098
• Length: 1922
• Species: Homo sapiens
• Sequence 2: NP_477436.1
• Gene: drosha / 35747
• FlyBaseID: FBgn0026722
• Length: 1327
• Species: Drosophila melanogaster
• Alignment Length: 1655
• Identity: 302/1655 - (18%)
• Similarity: 487/1655 - (29%)
• Gaps: 704/1655 - (42%)

Human   389 PYERQQFESVEWYNNRNQ--DNYVSWS-----DSEDDDEDEEIEEKEKPETNFPSPFTNILCGII 446
            |.|||::.|    |:.:|  .:|..:|     :...|.|..:|::.
  Fly   131 PSERQRYTS----NSSSQGYHHYPGYSSGRRYEQRHDQEHRQIQDS------------------- 172

Human   447 FVERRYTAVVLNRLIKEAGKQDPELAYISSNFITG--HGIGKNQPRNKQMEAEF-------RKQE 502
                ||.             .:|...:.:.....|  ||...:..|| |:..::       |::.
  Fly   173 ----RYA-------------HEPRHGHYAHRQAKGSQHGYYGSAARN-QVSDDYSPRGHHERERN 219

Human   503 EVLRKFRAH-----ETNLLI---ATSIVEEGVD-IPKCNLVVRFDLPTEYRSYVQS--------- 549
            |.|.|.||.     |.:.|:   .::..|:..| :.|.|.:...|.|.|  |:|:|
  Fly   220 ETLEKTRAKPKVETERDRLLRQWCSNFCEKPEDYVKKMNALSEADAPVE--SWVRSSPAELYYER 282

Human   550 -------KGRARAPISNYIMLADTD---KIKSFEEDLKTY-----KAIEKILRNK-----CSKSV 594
                   :||||  :.....|.|.:   :.|...|.|..|     ||..::.::|     ||.|
  Fly   283 TKSENEVRGRAR--LQKLCTLFDEELLQRAKRVREKLPVYVPPPRKARRRVCKHKHKSEACSSS- 344

Human   595 DTGETDIDPVMDDDDVFPPYVLRPDDGGPRVTINTAIGHINR---YCARLPSDPFTHLAPKCRTR 656
              ..:|.|   .|:|.|            ::..:..:..::|   :..|:.:|.:.:.|     .
  Fly   345 --SSSDDD---SDEDAF------------KIEQDCCMEELSRKVQHPQRVHADLWHNDA-----G 387

Human   657 ELPDGTFYSTLYLPINSPLRASIVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVK 721
            |:.||            ||          |          .|..|..:||             ::
  Fly   388 EMNDG------------PL----------C----------RCSAKSRRIG-------------IR 407

Human   722 YEEELDLHDEEETSVPG-RPGSTKRRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDEL 785
            :               | .||.|..:.|.|.:            :....|:...:.::.|    .
  Fly   408 H---------------GIYPGETGYKLCDPNS------------NNAGKLFHYRISISPP----T 441

Human   786 NFRRR-----KLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFMLSLQMLEL 845
            ||..:     |....|.....|.:|:...:..:|...|...:.|.||..|.:|.....::..|::
  Fly   442 NFLTKTPTIIKHDEHEFLFEGFSLLSHVRLSDLPVCKVIRFNIEYTIEYEEEKMPENFTIHELDI 506

Human   846 ITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIP 910
               ..:|:|..:|.|                               :||..|.:         :|
  Fly   507 ---FFKYLFHELLEL-------------------------------VDFNLMPN---------LP 528

Human   911 STKYTKETP-FVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKT 974
            |....:..| |.|          .||          :|.|:          |....|..|.....
  Fly   529 SGNVEESCPAFHF----------FPR----------FVRDL----------PDNGKEVLAMVEVL 563

Human   975 KYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQ-------------KGKALPLSSAEKRKAKWES 1026
            :|.||    |...|     ..|..||   ||||             ||..:.....:....:.:.
  Fly   564 RYLLD----NSAQL-----VERQQLL---HLNQISQSEWQNYVDFIKGMLVTKPGYKPCSLRVDQ 616

Human  1027 LQNKQILVPELCA------IHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSL 1085
            |......:|| |.      .||   ::....:|.|.:.|       |.....|.|....|..|.|
  Fly   617 LDRNNSDLPE-CVDRETGISHP---AIVHFGICHPQLSY-------AGNPEYQKAWREYVKYRHL 670

Human  1086 PADFRYPNLDFGWKKSIDSKS----------------FISISNSSSAENDNYC---KHSTIVPEN 1131
            .|:...|:  |..|:.::.|.                .::||:.........|   :|:.::|..
  Fly   671 MANMSKPS--FKDKRKLEEKEQRLQEMRTQGRMKRNITVAISSEGFYRTGIMCDVVQHAMLIPVL 733

Human  1132 AAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHVEVSADLTAINGLSYNQNLANGSYDLANRDF 1196
            ..|        |..|..:.     ||.||.|...........|:...||.:|..      .|.|.
  Fly   734 TGH--------LRFHKSLD-----LLEESIGYRFKNRYLLQLALTHPSYKENYG------TNPDH 779

Human  1197 CQGNQLNYYKQEIPVQPTTSYSIQNLYSYENQPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVM 1261
            .:.:..|                               |.:...:|.|...:        .|...
  Fly   780 ARNSLTN-------------------------------CGIRQPEYGDRKIH--------YMNTR 805

Human  1262 PGTTDTIQVLKGRMDSEQSPSIGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHA 1326
            ....:|:..:..|...|..                     |:||.:..   ||||.|||:.::..
  Fly   806 KRGINTLVSIMSRFGKEHE---------------------TVSNITHN---ERLEFLGDAVVEFL 846

Human  1327 ITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDK 1391
            .:.:||..:|:..||.|:..|:..|.|.:|..|.||..|
  Fly   847 SSIHLFFMFPELEEGGLATYRAAIVQNQHLALLAKKLQL-------------------------- 885

Human  1392 SNTDKWEKDEMTKDCMLANGKLDEDYEEEDEEEESLMWRAPKEEADYEDDFLEYDQEHIRFIDNM 1456
                                                            ::|             |
  Fly   886 ------------------------------------------------EEF-------------M 889

Human  1457 LMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSLGSMPFSSDFEDFDYSSWDAMCYLDPSKAVEED 1521
            |...|             :|..:|.::
  Fly   890 LYAHG-------------SDLCHELEL-------------------------------------- 903

Human  1522 DFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAA-QLFLCS 1585
                                              ..::|:|.|||:|..|...|.:.| ::|
  Fly   904 ----------------------------------RHAMANCFEALMGALLLDGGIKVADEVF--- 931

Human  1586 LGLKVLPVIKRTDREKALCPTRENFNSQQKNLSVSCAAASVASSRSSVLKDSE----YGCLKIPP 1646
                       ||   ||....|...|..|||.            ...|::.|    ..|:
  Fly   932 -----------TD---ALFRQDEKLLSIWKNLP------------EHPLQEQEPLGDRSCI---- 966

Human  1647 RCMFDHPDADKTLNHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTIT-DCYQRLEFLGDA 1710
                   |:.:.|..|    ..||..|..:||:...|.:|||..|..:..:| ...||||||||.
  Fly   967 -------DSYRVLKEL----TKFEDSIGIKFKHIRLLARAFTDRSIGFTHLTLGSNQRLEFLGDT 1020

Human  1711 ILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQF 1775
            :|..:.:::||....:|..|.|:.|||:||||...|.:.......||....:|:
  Fly  1021 VLQLICSEYLYRHFPEHHEGHLSLLRSSLVNNRTQAVVCDDLGMPKYAVYANPK----------- 1074

Human  1776 QLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSG-MSLETVWQV-YYPMM 1838
                       ::|:              .|...|:.|:..||:|:|.| :..|....| .:|.:
  Fly  1075 -----------ADLK--------------TKDRADLLEAFLGALYVDKGLLYCEQFCHVCLFPRL 1114

Human  1839 RPLIEKFSANVPRSPVRE----LLEM---EPETAKFSPAE-------RTYDGKVRVTVEVVGKGK 1889
            :..|.....|.|:|.:::    |..|   ||:...:...|       |.|    :|.|....|..
  Fly  1115 QLFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPYYKVVEASGPTNTRVY----KVAVYFRSKRL 1175

Human  1890 FKGVGRSYRIAKSAAARRALRSLKANQPQV 1919
            ....|.|.:.|:..||::||.:.:...||:
  Fly  1176 ATSSGSSIQQAEMNAAKQALENSRDLFPQL 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DICER1	NP_085124.2	DEXHc_dicer	42..239	CDD:350792
		DECH box	175..178
		Required for interaction with PRKRA and TARBP2	256..595		55/259 (21%)
		Dicer_PBD	271..365	CDD:277191
		SF2_C_dicer	372..564	CDD:350189	43/215 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..433		5/28 (18%)
		Dicer_dimer	630..718	CDD:460900	14/90 (16%)
		PAZ_dicer_like	886..1008	CDD:239209	27/135 (20%)
		RIBOc	1296..>1387	CDD:197778	24/90 (27%)
		RIBOc	1682..1846	CDD:238333	44/166 (27%)
		DSRM_DICER	1851..1913	CDD:380680	18/75 (24%)
drosha	NP_477436.1	RIBOc	826..942	CDD:197778	44/307 (14%)
		Rnc	973..1196	CDD:440336	69/266 (26%)