DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXO46 and Pdfr

DIOPT Version :9

Sequence 1:	NP_001073938.1	Gene:	FBXO46 / 23403	HGNCID:	25069	Length:	603	Species:	Homo sapiens
Sequence 2:	NP_001245501.1	Gene:	Pdfr / 31234	FlyBaseID:	FBgn0260753	Length:	738	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	52/248 - (20%)
Similarity:	77/248 - (31%)	Gaps:	86/248 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   225 SRVAEAVAHFEAQRDSPPTKGLRKEERPGPGPG-------------EVRIAFRISNGREPRAPDS 276
            |.:.:......|||.   |:.||:....||.|.             |...:..::.||.|...|.
  Fly    74 SNILDCGGCISAQRF---TRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDF 135

Human   277 GLPSGGGGRPGCAYPGSPGPGARAKDKITCDLYQLISPS-RDALP-SNVEFLLARADEASEGD-- 337
            ...:            :..||....|.:.......:.|: .|||| |:.|.:|...:.::..:
  Fly   136 DAST------------TESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLT 188

Human   338 --SPAPARPE----------------------DT----PPAPPPPPARDCGASGFHVDVVVTGV- 373
              |.|....|                      ||    ||.|....||.....|||      ||
  Fly   189 LASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFH------GVD 247

Human   374 -----VDECIFFGKDGTKNVKEETVCLTVSPEEPPPPGQLFFLQNRGPDGPPE 421
                 :.:|...|:.|::          .:..|..|||...:    ||...||
  Fly   248 TRKFAIRKCELDGRWGSR----------PNATEVNPPGWTDY----GPCYKPE 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXO46	NP_001073938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..301		16/78 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..360		11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..440		8/26 (31%)
		F-box-like	473..>507	CDD:289689
Pdfr	NP_001245501.1	HRM	213..272	CDD:280888	16/74 (22%)
Pdfr	NP_001245501.1	7tm_4	306..563	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900