Protein Alignment ATP13A2 and YPK9

DIOPT Version :10

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: NP_014934.1
• Gene: YPK9 / 854466
• SGDID: S000005817
• Length: 1472
• Species: Saccharomyces cerevisiae
• Alignment Length: 1148
• Identity: 401/1148 - (34%)
• Similarity: 615/1148 - (53%)
• Gaps: 177/1148 - (15%)

Human    35 VRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKP-----LWGVRLRLRPCNLAHAETLVIEIRD 94
            :.::.|..|.:..|.|::..::..|:..||.||.|     |:||::     .||.||.:|||...
Yeast   310 IGIAAYQTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKV-----PLAKAEWVVIENEF 369

Human    95 KE------DSSW---QLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHK 150
            .|      |..|   .|.|| :..|.....|.||:                       |....|.
Yeast   370 GEFVIQPIDRQWYNRPLSTV-LPFENYPNPSYEPN-----------------------DINLSHH 410

Human   151 SEEAVSVGQRVLRYYLFQGQRYI-------------WIETQQAFYQVSLLDHGRSCDDVHRSRHG 202
            ....::....:|..:.::..::|             ||:....              |:....:|
Yeast   411 HANEINPNVPILITFEYRYIKFIYSPLDDLFKTNNNWIDPDWV--------------DLSTVSNG 461

Human   203 LSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISS 267
            |:...|..|:..:|.|.|::.:|:..::|.:|.|:|:|.||.|||.||..|.||:||.||||||.
Yeast   462 LTKGVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISV 526

Human   268 ISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEW--VDSSELVPGDCLVLPQEG-GLMPCD 329
            :||..||.:.:|.|:.|.:|......|.|.|   ::.|  :.||||||||...:.... .::|||
Yeast   527 LSIFDSLNEQKKVSRNLAEMSHFHCDVRVLR---DKFWTTISSSELVPGDIYEVSDPNITILPCD 588

Human   330 AALVAGECMVNESSLTGESIPVLK-TALPEGLGPYCAETH--------RRHTLFCGTLILQARAY 385
            :.|::.:|:||||.|||||:||.| .|..|.:...|.:..        .:..|:.||.|::||..
Yeast   589 SILLSSDCIVNESMLTGESVPVSKFPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIA 653

Human   386 VG-PHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRN 449
            .| ...||:|.||||.|.||.||.|::.|:|..||||:.|.|::..:|::|:.|...|.....:.
Yeast   654 PGQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKL 718

Human   450 RVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKT 514
            .:....:::||||::|:||||||||.:|:.|.:|.|||:.:|||||.|.|:|:.||:.::|||||
Yeast   719 GLDKKTMILRALDIITIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKT 783

Human   515 GTLTEDGLDVMGVV-----PLKGQAFLPLVPEPRRL-P-------VGPL-------LRALATCHA 559
            ||||||||||:||.     .::||.|..|:.:.|:: |       ..||       ..:|.|||:
Yeast   784 GTLTEDGLDVLGVQISEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSRNFFMSLLTCHS 848

Human   560 LSRLQDTPVGDPMDLKMVESTGWVLEEE------------PAADSAF--GTQVLAVMRPPLWEPQ 610
            |..:....:|||:|.||.:.|||..||:            ...|..|  .::::    |.:..|.
Yeast   849 LRSVDGNLLGDPLDFKMFQFTGWSFEEDFQKRAFHSLYEGRHEDDVFPENSEII----PAVVHPD 909

Human   611 LQAME------EPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVP 669
            ....|      :|...:.|:..|.|.|.|:||||:|.........::.||:||:::.:||..|:|
Yeast   910 SNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVISEICNKSTLP 974

Human   670 TDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPV 734
            .||.::|:.||..||||:|.|.|.||....| .:|:::|:.||.:|..||.::.:|.||.:|:..
Yeast   975 ADFEEVLRCYTHNGYRVIACAGKTLPKRTWL-YSQKVSREEVESNLEFLGFIIFQNKLKKETSET 1038

Human   735 IQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAV 799
            :::|:...||.:|.||||:.||::|.|..|::                  ..|..::|..:.|.:
Yeast  1039 LKSLQDANIRTIMCTGDNILTAISVGREAGLI------------------QCSRVYVPSINDTPL 1085

Human   800 NG--------VKDPDQAA-SYTVEPDPRSRH-----------LALSGPTFGIIVK---HFP-KLL 840
            :|        |.:||:.. :.|::|.....:           ||:||..|.::.:   ..| :.|
Yeast  1086 HGEPVIVWRDVNEPDKILDTKTLKPVKLGNNSVESLRECNYTLAVSGDVFRLLFRDENEIPEEYL 1150

Human   841 PKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPF 905
            .::|:..:::|||:|::|.||:.:||||.|.||.|||||||||||||||||||||:|||||.:||
Yeast  1151 NEILLNSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISLSEAEASVAAPF 1215

Human   906 TSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVIT 970
            ||.:.:|.||..||||||.:|.|||:.|:||:|||..|||::.|||:..:||||.|||.|||::.
Yeast  1216 TSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGDFQFLYIDLLLI 1280

Human   971 TTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFV-PLNRT 1034
            ..:|:.||.:.....:.:.||...|:|..:|..||:.:.||...|...:.:.....|:: |:
Yeast  1281 VPIAICMSWSKSYEKIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQKMSWYIKPI--- 1342

Human  1035 VAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            |...|.:.:.:|||:|.:|:|||::.|..:|.|.|:|.|:..|
Yeast  1343 VGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKN 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	400/1142 (35%)
YPK9	NP_014934.1	P-ATPase-V	307..1431	CDD:273738	401/1148 (35%)