DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP13A2 and YPK9

DIOPT Version :9

Sequence 1:	XP_005245867.1	Gene:	ATP13A2 / 23400	HGNCID:	30213	Length:	1201	Species:	Homo sapiens
Sequence 2:	NP_014934.1	Gene:	YPK9 / 854466	SGDID:	S000005817	Length:	1472	Species:	Saccharomyces cerevisiae

Alignment Length:	1148	Identity:	401/1148 - (34%)
Similarity:	615/1148 - (53%)	Gaps:	177/1148 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    35 VRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKP-----LWGVRLRLRPCNLAHAETLVIEIRD 94
            :.::.|..|.:..|.|::..::..|:..||.||.|     |:||::     .||.||.:|||...
Yeast   310 IGIAAYQTSKFWYIIYNLCCFLTFGLVYLLTRWLPHLKVKLYGVKV-----PLAKAEWVVIENEF 369

Human    95 KE------DSSW---QLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHK 150
            .|      |..|   .|.|| :..|.....|.||:                       |....|.
Yeast   370 GEFVIQPIDRQWYNRPLSTV-LPFENYPNPSYEPN-----------------------DINLSHH 410

Human   151 SEEAVSVGQRVLRYYLFQGQRYI-------------WIETQQAFYQVSLLDHGRSCDDVHRSRHG 202
            ....::....:|..:.::..::|             ||:....              |:....:|
Yeast   411 HANEINPNVPILITFEYRYIKFIYSPLDDLFKTNNNWIDPDWV--------------DLSTVSNG 461

Human   203 LSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISS 267
            |:...|..|:..:|.|.|::.:|:..::|.:|.|:|:|.||.|||.||..|.||:||.||||||.
Yeast   462 LTKGVQEDRELAFGKNQINLRMKTTSEILFNEVLHPFYVFQVFSIILWGIDEYYYYAACIFLISV 526

Human   268 ISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEW--VDSSELVPGDCLVLPQEG-GLMPCD 329
            :||..||.:.:|.|:.|.:|......|.|.|   ::.|  :.||||||||...:.... .::|||
Yeast   527 LSIFDSLNEQKKVSRNLAEMSHFHCDVRVLR---DKFWTTISSSELVPGDIYEVSDPNITILPCD 588

Human   330 AALVAGECMVNESSLTGESIPVLK-TALPEGLGPYCAETH--------RRHTLFCGTLILQARAY 385
            :.|::.:|:||||.|||||:||.| .|..|.:...|.:..        .:..|:.||.|::||..
Yeast   589 SILLSSDCIVNESMLTGESVPVSKFPATEETMYQLCDDFQSTQISSFVSKSFLYNGTNIIRARIA 653

Human   386 VG-PHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRN 449
            .| ...||:|.||||.|.||.||.|::.|:|..||||:.|.|::..:|::|:.|...|.....:.
Yeast   654 PGQTAALAMVVRTGFSTTKGSLVRSMVFPKPTGFKFYRDSFKYIGFMSLIAIFGFCVSCVQFIKL 718

Human   450 RVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKT 514
            .:....:::||||::|:||||||||.:|:.|.:|.|||:.:|||||.|.|:|:.||:.::|||||
Yeast   719 GLDKKTMILRALDIITIVVPPALPATLTIGTNFALSRLKEKGIFCISPTRLNISGKIDVMCFDKT 783

Human   515 GTLTEDGLDVMGVV-----PLKGQAFLPLVPEPRRL-P-------VGPL-------LRALATCHA 559
            ||||||||||:||.     .::||.|..|:.:.|:: |       ..||       ..:|.|||:
Yeast   784 GTLTEDGLDVLGVQISEPNGVRGQKFGELLSDIRQVFPKFSLNDCSSPLDFKSRNFFMSLLTCHS 848

Human   560 LSRLQDTPVGDPMDLKMVESTGWVLEEE------------PAADSAF--GTQVLAVMRPPLWEPQ 610
            |..:....:|||:|.||.:.|||..||:            ...|..|  .::::    |.:..|.
Yeast   849 LRSVDGNLLGDPLDFKMFQFTGWSFEEDFQKRAFHSLYEGRHEDDVFPENSEII----PAVVHPD 909

Human   611 LQAME------EPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVP 669
            ....|      :|...:.|:..|.|.|.|:||||:|.........::.||:||:::.:||..|:|
Yeast   910 SNNRENTFTDNDPHNFLGVVRSFEFLSELRRMSVIVKTNNDDVYWSFTKGAPEVISEICNKSTLP 974

Human   670 TDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPV 734
            .||.::|:.||..||||:|.|.|.||....| .:|:::|:.||.:|..||.::.:|.||.:|:..
Yeast   975 ADFEEVLRCYTHNGYRVIACAGKTLPKRTWL-YSQKVSREEVESNLEFLGFIIFQNKLKKETSET 1038

Human   735 IQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAV 799
            :::|:...||.:|.||||:.||::|.|..|::                  ..|..::|..:.|.:
Yeast  1039 LKSLQDANIRTIMCTGDNILTAISVGREAGLI------------------QCSRVYVPSINDTPL 1085

Human   800 NG--------VKDPDQAA-SYTVEPDPRSRH-----------LALSGPTFGIIVK---HFP-KLL 840
            :|        |.:||:.. :.|::|.....:           ||:||..|.::.:   ..| :.|
Yeast  1086 HGEPVIVWRDVNEPDKILDTKTLKPVKLGNNSVESLRECNYTLAVSGDVFRLLFRDENEIPEEYL 1150

Human   841 PKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPF 905
            .::|:..:::|||:|::|.||:.:||||.|.||.|||||||||||||||||||||:|||||.:||
Yeast  1151 NEILLNSSIYARMSPDEKHELMIQLQKLDYTVGFCGDGANDCGALKAADVGISLSEAEASVAAPF 1215

Human   906 TSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVIT 970
            ||.:.:|.||..||||||.:|.|||:.|:||:|||..|||::.|||:..:||||.|||.|||::.
Yeast  1216 TSKIFNISCVLDVIREGRAALVTSFACFQYMSLYSAIQFITITILYSRGSNLGDFQFLYIDLLLI 1280

Human   971 TTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFV-PLNRT 1034
            ..:|:.||.:.....:.:.||...|:|..:|..||:.:.||...|...:.:.....|:: |:
Yeast  1281 VPIAICMSWSKSYEKIDKKRPSANLVSPKILVPLLISVFLVFLFQFIPWIIVQKMSWYIKPI--- 1342

Human  1035 VAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            |...|.:.:.:|||:|.:|:|||::.|..:|.|.|:|.|:..|
Yeast  1343 VGGDDAVQSSDNTVLFFVSNFQYILTAIVLSVGPPYREPMSKN 1385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	400/1142 (35%)
		P5-ATPase	39..>114	CDD:289194	27/88 (31%)
		E1-E2_ATPase	262..497	CDD:278548	101/247 (41%)
		Cation_ATPase	<627..663	CDD:289987	13/35 (37%)
		COG4087	<849..>898	CDD:226572	35/48 (73%)
YPK9	NP_014934.1	P-ATPase-V	307..1431	CDD:273738	401/1148 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159045686
Domainoid	1	1.000	232	1.000	Domainoid score	I457
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	696	1.000	Inparanoid score	I102
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		otm52705
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	O	PTHR45630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R101
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790