Protein Alignment ATP13A2 and atp13a-like

DIOPT Version :9

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: XP_004914468.2
• Gene: atp13a-like / 733496
• XenbaseID: XB-GENE-5883964
• Length: 1245
• Species: Xenopus tropicalis
• Alignment Length: 1170
• Identity: 415/1170 - (35%)
• Similarity: 605/1170 - (51%)
• Gaps: 153/1170 - (13%)

Human    14 TGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLR 78
            |.:|.:..|        |.:..::.||....||....:|...:..|:...|..||....|.....
 Frog     8 THHGIVNEG--------SENEFQVFGYRTKRWRQALCYVGYVLSLGLIRFLLYWKQEMYVWFVCN 64

Human    79 PCNLAHAETLVIEIRD-------KEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGA 136
            ||:|..|:.|::...|       |:..|:.                                |..
 Frog    65 PCSLEEADILLLRTTDEQKKCCMKKVKSFH--------------------------------VAN 97

Human   137 VPEGAW--KDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVH-R 198
            |...|:  .:||:...|:|.....:..:||...|..||||...:..|.:..:||...||.|:| :
 Frog    98 VSHIAYMNNNTAEKKDSKELPVNTELKVRYMHVQKMRYIWNPFRGTFQKSGVLDDTHSCSDIHTK 162

Human   199 SRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIF 263
            ...|.|.::|..|:.|.|.|.|.:.:....:||..|.|||.|.|:|:::.|||:..|..|::.|.
 Frog   163 FASGFSKEEQDNRRQICGSNSIEVEITPIWKLLFREILNPVYCFEAYALILWLSAGYIEYSMAIL 227

Human   264 LISSISICLSLYKTRKQSQTLRDMVKL--SMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLM 326
            :::.:||..::...|.||..|..||:.  ::.|.|.|..|:.|.|.|..|||||.::||::...:
 Frog   228 ILTILSIIATVTLLRMQSVKLHKMVEFHNNVMVTVLRKTGDIEEVQSQNLVPGDVIILPEKKMYL 292

Human   327 PCDAALVAGECMVNESSLTGESIPVLKTALP--EGLGP---YCAETHRRHTLFCGTLILQARAYV 386
            ||||.|::|.|::||..||||.:||.||.||  :...|   |..:.::.|.|:|||.:.:.:...
 Frog   293 PCDAILISGGCVINEGMLTGECVPVTKTPLPCVDNCIPWNVYTGDNYKEHMLYCGTEVTKTKPDS 357

Human   387 GPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRV 451
            ...|.|||..|||.|.||.||.|||:|:||.||.||.....:|||||:::.|.|||:.:......
 Frog   358 DGLVKAVVLHTGFNTTKGDLVRSILYPKPIKFKLYKDVFWVIAALSVVSVFGLIYSVVVGALQGA 422

Human   452 PLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGT 516
            ...::|:....::|..||.:||.|:.||.||:|:||::.|||||.|.||:|.|:|.|:|||||||
 Frog   423 EPKDLVLMGFIMLTCAVPVSLPPALAVCVLYSQNRLKKHGIFCISPDRISLCGQLNLICFDKTGT 487

Human   517 LTEDGLDVMGVVPLKGQAFLPL--VPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVES 579
            |||:|||:.|:||.:...|...  ......||.||||.|:|:||:|..|.....|||:|.||.|.
 Frog   488 LTEEGLDLWGIVPSRENCFQEAHHFTSGSTLPWGPLLGAVASCHSLIVLDGAIHGDPLDFKMFEG 552

Human   580 TGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVP-VSVLHRFPFSSALQRMSVVVAWP 643
            :||.::|..|..:..|.....|...|      .:..:.||. :::|.:|||||||||||||....
 Frog   553 SGWNIDESQATCTVDGKCCSCVTVKP------GSGSKVPVDGINILLQFPFSSALQRMSVVAQVI 611

Human   644 GATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTR 708
            |..:...::||:||:|...|..||||:.|...|..||..|:||::||.|......:: :...|.|
 Frog   612 GEQRLTLFLKGAPEMVVRFCKQETVPSSFKNTLDYYTEQGFRVISLAYKYFELEENI-SLPNLKR 675

Human   709 DTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLI 773
            :.||.||..||.|:|.|.|||:|.||:|.|....:|.||:|||||:||.||..|.|||...:::.
 Frog   676 EEVESDLIFLGFLIMENQLKPETKPVLQELVSANLRTVMLTGDNLKTACTVGMGSGMVPSTDNVF 740

Human   774 IVHATHPERG-QP-------------------ASLEFLPMESPTAVNGVKDP-DQAASYT----- 812
            ::.||..|.| ||                   .::..|..::....|.:::. |.|.|.|
 Frog   741 LLEATEYEEGTQPFINWQILKRNKDNDTKLNETTVNILCTDNAIKCNTIQNKLDYATSGTYYSTD 805

Human   813 ---------------------VEP-----------------DPRSR-------HLALSGPTFGII 832
                                 |.|                 .|.|.       |.|::|.::..|
 Frog   806 KQNLPELMMPNVCLLPSVFADVAPSVAAVAFSKTGENIQSESPSSHYIKQHKYHYAMTGNSYQTI 870

Human   833 VKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQA 897
            .:|||.|:|.:|:.||:||||.|:||:.::.:||.:.|.|||||||||||||||.|..|||||:.
 Frog   871 KQHFPDLMPDILLNGTIFARMTPKQKSTMIEDLQNIDYYVGMCGDGANDCGALKMAHAGISLSEL 935

Human   898 EASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQF 962
            ||||.|||||.:.:|.|:|::::|||....|..|:||||.:|:....|.:.:::...|.||..|:
 Frog   936 EASVASPFTSKITNITCMPILLKEGRNVFVTYISLFKYMVMYAFIGLICMFLMFWEQTILGSNQY 1000

Human   963 LAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPW 1027
            |..|:.||..:.:.:|..|||..|...||.|.||..|:|.|::|.:.....||:..||:...|||
 Frog  1001 LMQDIAITIPLMLTLSLNGPAPKLAPYRPAGRLLLPPLLLSIILHLSFTLTVQMCAYFVLQQQPW 1065

Human  1028 F---------VPLNRTVA---AP---DNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            |         :|.|.:.|   :|   |...|:..:..:.::....:|:....|||.|||:|:|||
 Frog  1066 FSRTDVFYACIPQNMSFANQTSPMEYDISQNFFTSTCWLITGINLIIIEFVFSKGRPFRQPIYTN 1130

Human  1078  1077
             Frog  1131  1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	409/1143 (36%)
		P5-ATPase	39..>114	CDD:289194	18/81 (22%)
		E1-E2_ATPase	262..497	CDD:278548	99/241 (41%)
		Cation_ATPase	<627..663	CDD:289987	19/35 (54%)
		COG4087	<849..>898	CDD:226572	31/48 (65%)
atp13a-like	XP_004914468.2	P5-ATPase	17..138	CDD:403569	32/152 (21%)
		P-type_ATPase_cation	170..1066	CDD:319842	351/902 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010