DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP13A2 and atp13a2

DIOPT Version :9

Sequence 1:	XP_005245867.1	Gene:	ATP13A2 / 23400	HGNCID:	30213	Length:	1201	Species:	Homo sapiens
Sequence 2:	NP_001073506.1	Gene:	atp13a2 / 568666	ZFINID:	ZDB-GENE-061215-126	Length:	1170	Species:	Danio rerio

Alignment Length:	1084	Identity:	561/1084 - (51%)
Similarity:	729/1084 - (67%)	Gaps:	51/1084 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     2 SADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFR 66
            |.|:.||: ..|.           .|..|.||.:.:.||....|:|....:......|:.|:||:
Zfish    17 SPDTEPLI-KDPR-----------PPELSLVSHMDVQGYRWVCWKVWLCRIGAVFSVGLLLVLFK 69

Human    67 WKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQ 131
            |:|..|:..|.:.|.::.|:.|::     :|...|.|.|.|.||.:.||||:
Zfish    70 WRPRIGILARCKSCPISMADVLLL-----KDRYGQQFVVDVITEEVEEGSLD------------- 116

Human   132 AAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDV 196
            .|||...|..|:||.|||..::.      :||||:|:|.|||||..:.||.:.|:|..|.:|.|:
Zfish   117 FAVGDADENEWRDTVQLHSEKKT------LLRYYVFEGIRYIWISKKGAFCKASVLSEGWTCADL 175

Human   197 HRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALC 261
            |..:.|||..||..||.|:|.|:|.:|||||.|||.:|.|||:|.||.|||.||::|.|.:||.|
Zfish   176 HGQQQGLSRADQSTRKQIFGANIIDVPVKSYLQLLFEEVLNPFYIFQVFSIILWMSDGYVYYAAC 240

Human   262 IFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLM 326
            ||:||.|||.:|||:|||||.|||.|..|.:.|.|.|..||||.|.|.|||||||:|:|.||.|:
Zfish   241 IFIISLISIGVSLYETRKQSTTLRRMACLIVNVTVRRDTGEEECVSSEELVPGDCVVIPAEGLLL 305

Human   327 PCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQAR-AYVGPHV 390
            ||||||||||||||||.||||||||:||.|......|..|:.|||||||||.|:||: ...|...
Zfish   306 PCDAALVAGECMVNESMLTGESIPVMKTPLSNSEATYNPESQRRHTLFCGTQIIQAKGGGPGKGA 370

Human   391 LAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNE 455
            :||||.|||.||||.|:||||:|:|::|:||:.:|||:..|.:|||:|||||:.||.::..|..|
Zfish   371 IAVVTCTGFLTAKGDLISSILYPQPLDFRFYRDAMKFLLFLGLLALIGTIYSLVILSKSNTPWKE 435

Human   456 IVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTED 520
            ::||:||:||::||||||||:|..|:|||:||:|||:|||.|.|||:.||:.|.||||||||||:
Zfish   436 LIIRSLDIVTIIVPPALPAAITTATIYAQNRLKRQGVFCISPPRINICGKISLFCFDKTGTLTEE 500

Human   521 GLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVL- 584
            ||||.||:.:.|..|..|||:|..||.|.:|.|||:||:::.|....:|||::|||:|||||.|
Zfish   501 GLDVWGVMEVTGGVFGELVPDPLFLPPGLMLSALASCHSVALLGGQALGDPLELKMIESTGWELT 565

Human   585 --EEEPAADSAF-GTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGAT 646
              |.:...||.| |.:||||||||..| .|........||:::.||||||:|||||||...|...
Zfish   566 EPENDMGHDSEFGGHRVLAVMRPPASE-LLTEGNSVSQPVAIVRRFPFSSSLQRMSVVTVGPAEP 629

Human   647 QPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTV 711
            .|.|::||:||:||..|:.|:||:.|:..|:.|.:.|:||:.||.|.|.....|...:   |..|
Zfish   630 SPVAFIKGAPEMVASFCHKESVPSHFSHTLREYASQGFRVLGLAYKHLAKETDLSTVE---RVEV 691

Human   712 EGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVH 776
            |..::.||||||:|.:||::..|||.|...::|.|||||||:.|||.|||.||||...|.:|.||
Zfish   692 EKGMNFLGLLVMKNQVKPESAEVIQTLTLAQLRPVMVTGDNILTAVNVARVCGMVPLHEKVIFVH 756

Human   777 ATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSR---HLALSGPTFGIIVKHFPK 838
            |:.|..|..|||:|...|..||....:   |.....|:...:|.   |||::|.:|..:..|||:
Zfish   757 ASPPTAGSQASLQFHEGEGATATINTQ---QTIDIPVQGQYQSAVGYHLAINGMSFAALCDHFPE 818

Human   839 LLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVS 903
            .|||||::||::|||.|||||:||..||||.|.||||||||||||||:|||||:|||.|||||.|
Zfish   819 YLPKVLMRGTIYARMTPEQKTQLVKALQKLNYRVGMCGDGANDCGALRAADVGVSLSDAEASVAS 883

Human   904 PFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLV 968
            ||||...:|.|||::|:||||||.||||:|||||||||.||.|||||||..|||||||||..|||
Zfish   884 PFTSKSDNISCVPLLIKEGRCSLVTSFSLFKYMALYSLIQFASVLILYTEKTNLGDLQFLFFDLV 948

Human   969 ITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNR 1033
            :.|.:|:||.|.||:..|...||..:|||:|||:|||:..||:...|:.|..:|::|.|:||||.
Zfish   949 LVTVLAILMGRGGPSNDLHPQRPAASLLSLPVLASLLMHTVLLILAQVSGLLITMSQDWYVPLNS 1013

Human  1034 TVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            |.....||||.|:|.||::|.|||:|::..::||.|:::|||.|
Zfish  1014 TRTGAANLPNMEDTSVFAVSGFQYIIMSVVITKGFPYKKPLYHN 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	551/1045 (53%)
		P5-ATPase	39..>114	CDD:289194	22/74 (30%)
		E1-E2_ATPase	262..497	CDD:278548	147/235 (63%)
		Cation_ATPase	<627..663	CDD:289987	21/35 (60%)
		COG4087	<849..>898	CDD:226572	37/48 (77%)
atp13a2	NP_001073506.1	P5-ATPase	36..152	CDD:289194	44/139 (32%)
		P-ATPase-V	42..1102	CDD:273738	552/1047 (53%)
		Cation_ATPase_N	<179..229	CDD:279080	29/49 (59%)
		E1-E2_ATPase	241..478	CDD:278548	147/236 (62%)
		Cation_ATPase	<606..646	CDD:289987	22/39 (56%)
		HAD_like	<832..885	CDD:304363	42/52 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339978
Domainoid	1	1.000	410	1.000	Domainoid score	I4392
eggNOG	1	0.900	-	-		E2759_KOG0208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56940
Inparanoid	1	1.050	1105	1.000	Inparanoid score	I1878
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		oto43257
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	LDO	PTHR45630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.270