DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP13A2 and Atp13a2

DIOPT Version :9

Sequence 1:	XP_005245867.1	Gene:	ATP13A2 / 23400	HGNCID:	30213	Length:	1201	Species:	Homo sapiens
Sequence 2:	XP_006239308.1	Gene:	Atp13a2 / 362645	RGDID:	1307977	Length:	1173	Species:	Rattus norvegicus

Alignment Length:	1077	Identity:	920/1077 - (85%)
Similarity:	970/1077 - (90%)	Gaps:	6/1077 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLF 65
            ||||||||:||||..||||..|||||||||||||||||||||||||.||||..|||:||||.|||
  Rat     1 MSADSSPLLGSTPPSYGTLMTGTSIDPLSSSVSSVRLSGYCGSPWRAIGYHAAVWMLAGIPWLLF 65

Human    66 RWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRS 130
            |||||||||||||||:||.||||||||||||.||.|||||||||||:.:||||...|::||||||
  Rat    66 RWKPLWGVRLRLRPCSLARAETLVIEIRDKEGSSRQLFTVQVQTEAVVDGSLELPSQAKAEDGRS 130

Human   131 QAAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDD 195
            .||||..||..|:||.|||:.:||    ::|||||:.|||||:|:||||||.|||||||||:|||
  Rat   131 LAAVGVAPESMWQDTTQLHRQKEA----KQVLRYYILQGQRYVWMETQQAFCQVSLLDHGRACDD 191

Human   196 VHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYAL 260
            :|.|..|||||||.|||.|||||||.||||||.|||||||||||||||||||||||||||||||:
  Rat   192 IHCSSSGLSLQDQAVRKTIYGPNVIGIPVKSYLQLLVDEALNPYYGFQAFSIALWLADHYYWYAV 256

Human   261 CIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGL 325
            ||||||:||||||||||||||.|||||||||:||.|||||||||||||||||||||||||||||:
  Rat   257 CIFLISAISICLSLYKTRKQSMTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGM 321

Human   326 MPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHV 390
            ||||||||||||:|||||||||||||||||||||..|||.|||||||||||||:||||||:||.|
  Rat   322 MPCDAALVAGECVVNESSLTGESIPVLKTALPEGPQPYCPETHRRHTLFCGTLVLQARAYLGPRV 386

Human   391 LAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNE 455
            ||||||||||||||||||||||||||:||||:|||||||||||||||||||||.||||||||:.|
  Rat   387 LAVVTRTGFCTAKGGLVSSILHPRPISFKFYRHSMKFVAALSVLALLGTIYSIIILYRNRVPVKE 451

Human   456 IVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTED 520
            |||||||||||||||||||||||||||||||||.|||||||||||||||||:|||||||||||||
  Rat   452 IVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTED 516

Human   521 GLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLE 585
            |||:|||||||||..|||||||..||.|||||||.||||||:|.||.||||||||||||||||||
  Rat   517 GLDIMGVVPLKGQMLLPLVPEPCHLPPGPLLRALVTCHALSQLHDTLVGDPMDLKMVESTGWVLE 581

Human   586 EEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEA 650
            |..||.||..||||.|||||...||.|  ||.|.|||||.|||||||||||.|||.|||||||||
  Rat   582 EGSAAGSAPETQVLVVMRPPPRGPQQQ--EESPEPVSVLRRFPFSSALQRMDVVVTWPGATQPEA 644

Human   651 YVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDL 715
            ||||||||||.||:|||||.||.|:|||||||||||||||.|||||.|||||||||||||||.:|
  Rat   645 YVKGSPELVASLCSPETVPRDFPQVLQSYTAAGYRVVALAGKPLPTAPSLEAAQQLTRDTVEQEL 709

Human   716 SLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHP 780
            |||||||||||||||||||||.||:|.||.|||||||||||||||:.||||..||||.|:|||||
  Rat   710 SLLGLLVMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTVAKACGMVGTQEHLAIIHATHP 774

Human   781 ERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLV 845
            |:||||:|||||.|...|:||.|||.||..|.|||:.:||||||||.||.::.||||||||||||
  Rat   775 EQGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEPESQSRHLALSGSTFAVLQKHFPKLLPKVLV 839

Human   846 QGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMA 910
            |.||||||||||||:||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   840 QATVFARMAPEQKTQLVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMA 904

Human   911 SIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAV 975
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
  Rat   905 SIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLFITTTVAV 969

Human   976 LMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDN 1040
            |||||||||.|.|.||||||||||||.|||||:.||.|:|||||||.:||||||||||||.||||
  Rat   970 LMSRTGPALTLVRARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDN 1034

Human  1041 LPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            ||||||||:||||.|||||||||||||||||:|||||
  Rat  1035 LPNYENTVIFSLSGFQYLILAAAVSKGAPFRQPLYTN 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	885/1037 (85%)
		P5-ATPase	39..>114	CDD:289194	64/74 (86%)
		E1-E2_ATPase	262..497	CDD:278548	216/234 (92%)
		Cation_ATPase	<627..663	CDD:289987	32/35 (91%)
		COG4087	<849..>898	CDD:226572	46/48 (96%)
Atp13a2	XP_006239308.1	P-ATPase-V	39..1116	CDD:273738	887/1039 (85%)
		P5-ATPase	39..>110	CDD:289194	61/70 (87%)
		E1-E2_ATPase	258..493	CDD:278548	216/234 (92%)
		Cation_ATPase	<621..658	CDD:289987	33/36 (92%)
		COG4087	<843..>892	CDD:226572	46/48 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83692264
Domainoid	1	1.000	639	1.000	Domainoid score	I4284
eggNOG	1	0.900	-	-		E2759_KOG0208
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56940
Inparanoid	1	1.050	1930	1.000	Inparanoid score	I1593
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		oto143326
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	LDO	PTHR45630
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270